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Purpose: estimation of the possibility of using a mixture of feed additive "BioGrom SC" and the food antibiotic "Monenzin" for normalizing metabolic processes in highly productive cows in the transit period.Materials and methods. Studies were conducted because of the tribal plant of the Leningrad region. Two groups of animals were selected on the principle of analogs (experimental and control) 20 goals in each. The experimental group of cows 21 days before the calving and for 14 days after the calves were given a mixture of feed additive "BioGrom SC" and the food antibiotic "Monenzin". For the cottage additives, calcium carbonate (chalk) was used as a filler in the amount of 250 g with the addition of 10-15 g. Supplements "BioGrom SC" by 1 head. The mixture was prepared at the rate of 20 goals and a food antibiotic "Monenzin" was added to it at the rate of 100 mg per 1 kg of a mixture of feed additive with filler. The resulting mixture was fed by animals of the experimental group. All animal experimental and control groups take blood for 21 days before the hotel. The total protein, beta hydroxy acid, acetoacetic acid, alkaline blood reserve, calcium-phosphoric ratio, glucose is determined. At the end of the transit period on the 21st day of lactation, the blood of animal control and experimental groups was repeatedly investigated.Results. In the cows of the experimental group, in comparison with the cows of the control group at the end of the transit period, a decrease in such biochemical indicators was observed as beta hydroxy acid (a decrease to 0.84 ± 0.03 mmol / l), acetoacetic acid (decrease to 0.4 ± 0, 04 mmol / l). The animals of the experimental group decreased the content of the general protein (77.0 ± 0.08 g / l). Also, the data of the backup alkalinity of blood (acidose indicator) are within reference values. Calcium phosphorus ratio was also within the normal range.Conclusion. Introduction to the diet of a mixture of feed additive "BioGrom SC" and food antibiotic "Monenzin" normalize some biochemical blood indicators in cows in the transit period. At the same time, without correction of metabolic processes, cows are observed ketosis and acidosis, which can lead to premature disposal of animals from herd and as a result of economic losses. Thus, the use of the mixture is shown for the prevention and treatment of acidosis of the scar, metabolic acidosis, ketosis in cattle of the dairy direction of productivity.

Summary Background Several chemical agents are currently used to perform superficial peels of the face to reduce facial hyperpigmentation and fine lines/wrinkles. Some of the most commonly used agents are alpha hydroxyl acids, such as glycolic acid (GA), or beta hydroxy acid, such as salicylic acid. Aim This study aims to compare the efficacy of GA to that of a novel derivative of salicylic acid, capryloyl salicylic acid (LHA). Subjects/Methods In a split-face study, 50 female volunteers between the ages of 35 and 60 years with mild to moderate facial hyperpigmentation and fine lines/wrinkles were randomized and LHA or GA peel was applied to one side of the face. Increasing peel concentrations were applied (5 ‐10% LHA or 20 ‐ 50% GA) based on the tolerance level of the subjects and clinical observations of an expert dermatologist for 12 weeks at biweekly intervals. Results Of the 44 volunteers who completed the study, at 12 weeks 41% of LHA-treated and 30% of GA-treated subjects demonstrated significant reduction of fine lines/wrinkles compared to baseline. Forty-six percent of LHA-treated subjects and 34% of GA-treated subjects showed significant reduction of hyperpigmentation compared to baseline. LHA treatment was better than GA peels, although there were no statistically significant differences between the two groups. Conclusions Five percent to 10% of LHA peel is generally safe and as effective as 20 ‐ 50% GA peel in reducing facial hyperpigmentation and fine lines/wrinkles.

Two beta-hydroxy acids, malic and salicylic acids were combined with a non-ionic surfactant, a commercial pentaoxyethylene sorbitan mono-oleate and water to form a simple model of a skin lotion and the phase diagrams were determined. One emulsion formulation with relative amounts of the three components similar to those in commercial lotions was used to observe microscopically the changes in the emulsion structure during evaporation. The microscope images were subsequently compared to the information from the phase diagram under equilibrium conditions. The results showed the behavior of the systems of the two acids to be distinctly different; as exemplified by that of a typical formulation with 3% by weight of acid and 5% of surfactant. The malic acid system consisted of vesicles, exclusively formed by the surfactant and water, in an aqueous molecular solution of the acid and the initial evaporation resulted in an increase of the acid concentration in the aqueous solution to reach 35.5%, before solid crystals of the acid solid solution appeared. The salicylic acid formulation, on the other hand, already at the beginning of the determination consisted of water, particles of the acid solid solution and surfactant vesicles. In both cases the remaining deposit after total evaporation was particles of a solid acid solution and liquid surfactant.

Scission des (t-butyl-3dialkyl) isoxazolines-2 produisant des (dimethyl-2,2 hydroxy-5) alcanones-3(I). L'oxydation selon Baeyer Villiger de (I) conduit aux β-hydroxyesters

beta-Hydroxy acid dehydrogenase (beta-Had-2) of Anopheles albimanus was assigned to chromosome 3. The apparent sequence of loci on chromosome 3 is hexokinase-1--22--stripe--28--beta-hydroxy acid dehydrogenase-2--4--aldehyde oxidase--2--esterase-8--4--esterase-4--?--phosphoglucomutase--?--esterase-6. beta-Hydroxy acid dehydrogenase is 25 and 30 map units from phosphoglucomutase and esterase-6, respectively. The one-band electromorph of beta-Had-2 in homozygotes and the three-band type in heterozygotes suggest that the enzyme is a dimer. A variety of electrophoretic techniques and spectrophotometric analysis were used to determine if the allozymes of beta-Had-2 can be differentiated on a basis other than mobility. No differences were detected among the allozymes on the basis of thermostability, urea denaturation, response to thiol reagents, chelating agents, or changes in coenzyme and substrate concentrations. No heterogeneity within allozymes separated by electrophoresis was detected by using thermostability tests.