1. Potentiation of Antibiotic Activity by a Meldrum’s Acid Arylamino Methylene Derivative against Multidrug-Resistant Bacterial Strains
- Author
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José Bezerra de Araújo-Neto, Priscilla Ramos Freitas, Michele Caroline Nasato, Ana Carolina Justino de Araújo, Luiz Everson da Silva, Iêda Maria Begnini, Henrique Douglas Melo Coutinho, Saulo R. Tintino, Maria Isabel Lacowicz Krautler, Cícera Datiane de Morais Oliveira-Tintino, Maria D.M.C. Ribeiro da Silva, Jaime Ribeiro-Filho, Ricardo Andrade Rebelo, and Sandro Lucio Mireski more...
- Subjects
0106 biological sciences ,0303 health sciences ,animal structures ,030306 microbiology ,medicine.drug_class ,Chemistry ,Antibiotics ,Short Communications ,Meldrum's acid ,medicine.disease_cause ,01 natural sciences ,Microbiology ,03 medical and health sciences ,chemistry.chemical_compound ,Minimum inhibitory concentration ,Staphylococcus aureus ,010608 biotechnology ,medicine ,Lomefloxacin ,Ofloxacin ,Antibacterial activity ,Norfloxacin ,medicine.drug - Abstract
This study aimed to evaluate the intrinsic antibacterial activity and antibiotic-enhancing effect of an arylamino methylene derivative (MAD) in association with fluoroquinolones. The antibacterial activity against multiresistant Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli was analyzed by determining the minimum inhibitory concentration (MIC) using the broth micro dilution method. A reduction in the MIC of the fluoroquinolones against strains treated simultaneously with the MAD was interpreted as an enhanced antibiotic activity. While the MAD exhibited no clinically effective action (MIC ≥ 1.024 µg/mL), it was found to significantly potentiate the activity of norfloxacin, ofloxacin and lomefloxacin against all the strains, which may be related to structural similarities between the MAD and quinolones. Our findings suggest that Meldrum’s acid arylamino derivatives may represent promising molecules in the elaboration of new drugs to reverse resistance to fluoroquinolones. more...
- Published
- 2020
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