1. Products of Oxidative Guanine Damage Form Base Pairs with Guanine
- Author
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Katsuhito Kino, Taishu Kawada, Masayo Hirao-Suzuki, Hiroshi Miyazawa, and Masayuki Morikawa
- Subjects
0301 basic medicine ,Guanine ,DNA damage ,Base pair ,Stereochemistry ,G-C transversions ,Review ,Catalysis ,Inorganic Chemistry ,lcsh:Chemistry ,Betacoronavirus ,03 medical and health sciences ,chemistry.chemical_compound ,RNA polymerase ,base pair ,Animals ,Humans ,Point Mutation ,Physical and Theoretical Chemistry ,Base Pairing ,Molecular Biology ,lcsh:QH301-705.5 ,Spectroscopy ,Triazine ,2019 novel coronavirus ,oxidative guanine damage ,030102 biochemistry & molecular biology ,Chemistry ,SARS-CoV-2 ,Point mutation ,Organic Chemistry ,RNA ,General Medicine ,Ribonucleoside ,Computer Science Applications ,030104 developmental biology ,lcsh:Biology (General) ,lcsh:QD1-999 ,Oxidation-Reduction ,base incorporation ,DNA Damage - Abstract
Among the natural bases, guanine is the most oxidizable base. The damage caused by oxidation of guanine, commonly referred to as oxidative guanine damage, results in the formation of several products, including 2,5-diamino-4H-imidazol-4-one (Iz), 2,2,4-triamino-5(2H)-oxazolone (Oz), guanidinoformimine (Gf), guanidinohydantoin/iminoallantoin (Gh/Ia), spiroiminodihydantoin (Sp), 5-carboxamido-5-formamido-2-iminohydantoin (2Ih), urea (Ua), 5-guanidino-4-nitroimidazole (NI), spirodi(iminohydantoin) (5-Si and 8-Si), triazine, the M+7 product, other products by peroxynitrite, alkylated guanines, and 8,5′-cyclo-2′-deoxyguanosine (cG). Herein, we summarize the present knowledge about base pairs containing the products of oxidative guanine damage and guanine. Of these products, Iz is involved in G-C transversions. Oz, Gh/Ia, and Sp form preferably Oz:G, Gh/Ia:G, and Sp:G base pairs in some cases. An involvement of Gf, 2Ih, Ua, 5-Si, 8-Si, triazine, the M+7 product, and 4-hydroxy-2,5-dioxo-imidazolidine-4-carboxylic acid (HICA) in G-C transversions requires further experiments. In addition, we describe base pairs that target the RNA-dependent RNA polymerase (RdRp) of RNA viruses and describe implications for the 2019 novel coronavirus (SARS-CoV-2): When products of oxidative guanine damage are adapted for the ribonucleoside analogs, mimics of oxidative guanine damages, which can form base pairs, may become antiviral agents for SARS-CoV-2.
- Published
- 2020