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A method for the selective electrochemical aminoxyl-mediated Shono-type oxidation of pyrrolidines to pyrrolidinones is described. These transformations show the high selectivity and functional group compatibility. This chemistry also demonstrates the use of an operationally simple ElectraSyn 2.0 and cost-effective stainless-steel electrode for the electrochemical oxidation of functionalized pyrrolidines.

Two new siderophores, madurastatin D1 and D2, together with (-)-madurastatin C1, the enantiomer of a known compound, were isolated from marine-derived Actinomadura sp. The presence of an unusual 4-imidazolidinone ring in madurastatins D1 and D2 inspired us to sequence the Actinomadura sp. genome and to identify the mad biosynthetic gene cluster, knowledge of which enables us to now propose a biosynthetic pathway. Madurastatin D1 and D2 are moderately active in antimicrobial assays with M. luteus.

Based on the dioctadecyldimethylammonium chloride surfactant, three novel ionic liquids (ILs) involving dioctadecyldimethylammonium ([DODMA]+ cations and N,N-dialkyl-diglycolamide acid (DGA) anions was firstly designed and synthesized for extraction of thorium ions in nitric acid solution. The integrated extraction and solidification of Th(IV) was developed by formation of self-assembly (SA) solid in two-phase interface. The SA solid was identified by spectroscopic methods including SEM with mapping EDS, XPS, FT-IR and ESI-HRMS. The excellent extraction efficiency was observed for extraction of thorium using [DODMA]+[DGA]- ionic liquids, more than 99% of Th(IV) were extracted and enriched as SA solid in one-step process. The outstanding selectivity of Th(IV) to Ln(III) and U(VI) was observed, and separation factors were up to 3470 for Th/Eu and more than of 1980 for Th/U, respectively. The proposed strategy not only provides an alternate method for the separation of thorium ions with uranyl ions and lanthanides(III) ions in the nuclear fuel cycle, but also pioneers to develop the self-assembly extraction based on [DODMA]+ ionic liquids. In view of the similarity of Pu(IV) and Th(IV), the simple integrated strategy may be further expanded for extraction and enrichment of Pu(IV) in nuclear industry.

The sequential construction of diversified multifunctionalized thiazole derivatives through Pd-catalyzed regioselective C-H alkenylation has been accomplished. This versatile approach provides the diversified thiazole derivatives featuring orthogonal substitution patterns at the C-2, C-4 and C-5 positions from mono-substituted (2- or 4-substituted) thiazole derivatives or even more challenging simple thiazole.

An efficient regioselective arylation of thiazole derivatives via Pd-catalyzed C-H activation is reported. The transformation was hypothesized through a Pd(0/II) catalytic cycle in the absence of special ligand sets. This method provided an efficient process to direct arylation of thiazoles at the 5-position.

The sequential construction of diversified multifunctionalized thiazole derivatives through Pd-catalyzed regioselective C–H alkenylation has been accomplished. This versatile approach provides the diversified thiazole derivatives featuring orthogonal substitution patterns at the C-2, C-4 and C-5 positions from mono-substituted (2- or 4-substituted) thiazole derivatives or even more challenging simple thiazole.