14 results on '"Shi, Neng"'
Search Results
2. Enhanced mechanical properties of polyacrylamide/chitosan hydrogels by tuning the molecular structure of hyperbranched polysiloxane
- Author
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Shi-Neng Li, Long-Cheng Tang, Dechang Jia, Li-Xiu Gong, Baoqiang Li, Yujie Feng, Zhi-Ran Yu, and Yu Zhou
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Materials science ,Polyacrylamide ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Chitosan ,chemistry.chemical_compound ,Ultimate tensile strength ,lcsh:TA401-492 ,Molecule ,General Materials Science ,chemistry.chemical_classification ,Mechanical Engineering ,Polymer ,Epoxy ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,chemistry ,Chemical engineering ,Mechanics of Materials ,Covalent bond ,visual_art ,Self-healing hydrogels ,visual_art.visual_art_medium ,lcsh:Materials of engineering and construction. Mechanics of materials ,0210 nano-technology - Abstract
Hyperbranched polysiloxane (HSi) molecules with tunable molecular structure were synthesized and served as a novel crosslinker for fabricating polyacrylamide/chitosan (PCH) hydrogels. Various characterizations demonstrated that HSi molecules with tunable bi-functional vinyl and epoxy groups were successful prepared and utilized to optimize the network architecture and interactions of polymer chains. Benefiting from the structure of bi-functional crosslinker, PCH hydrogels demonstrated remarkably improved mechanical properties, superior to that of conventional crosslinker or HSi with single vinyl or epoxy group. A tensile strength of 302 kPa, elongation at break of 2263%, and toughness of 3.85 MJ·m–3 can be achieved by optimizing the molecular structure and content of HSi with bi-functional group (e.g. ratio of vinyl/epoxy = 0.68). Additionally, such hydrogels showed outstanding antifatigue ability to withstand cyclic compressive tests. Based on the structure observation and analysis, the improved mechanical properties are likely derived from the combination of homogeneous and strong polymer network and improved interactions of polymer chains (e.g. covalent and hydrogen bonds). Approaches in this study may inspire the design and development of novel crosslinker for fabricating mechanically robust hydrogels. Keywords: Hyperbranched polysiloxane, Tunable molecular structure, Hydrogel, Mechanical properties, Chitosan
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- 2019
3. Facile synthesis of super-hydrophobic, electrically conductive and mechanically flexible functionalized graphene nanoribbon/polyurethane sponge for efficient oil/water separation at static and dynamic states
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Li-Xiu Gong, Long-Cheng Tang, Hu Lili, Li Zhao, Qiang Fei, and Shi-Neng Li
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Materials science ,Graphene ,Scanning electron microscope ,General Chemical Engineering ,Composite number ,Oxide ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Silane ,Industrial and Manufacturing Engineering ,0104 chemical sciences ,law.invention ,chemistry.chemical_compound ,X-ray photoelectron spectroscopy ,chemistry ,Chemical engineering ,law ,Environmental Chemistry ,0210 nano-technology ,Graphene oxide paper ,Polyurethane - Abstract
Graphene oxide nanoribbons (GONRs) were synthesized and functionalized by silane molecules with different hydrophobic end-groups, and silane functionalized reduced GONR (silane-f-rGONR) coated polyurethane (PU) sponge composites were fabricated via a facile dip-coating process. Fourier-transform infrared, Raman spectrum, X-ray photoelectron spectroscopy and scanning electron microscopy demonstrated that silane molecules were successfully grafted onto GONR sheets, thus producing the ability to tune surface and physical properties of PU sponge from insulating and hydrophobic to conductive and super-hydrophobic. Cyclic compression and strain-induced electrical resistance change tests indicated that the porous silane-f-rGONR coated PU (silane-f-rGONR@PU) sponge composites exhibited excellent mechanical elasticity and durability and high sensitivity of resistance change. Furthermore, the two types of silane modified sponges showed different super-hydrophobicity and tunable oleophilicity/oleophobicity. Compared to the rGONR@PU composite with poor oil/water separation at dynamic state, these porous silane-f-rGONR@PU composites not only possessed excellent oil/solvent absorption capacity and selective oil/water separation at static state, but also showed good continuous oil/solvent pumping collection with high recyclability (>97% after 10 cycles) and outstanding oil/water separation efficiency at the dynamic shaking state. This work provides a new strategy for fabricating the super-hydrophobic, electrically conductive and mechanically flexible porous rGONR based composites, showing promising application in strain sensor and oil pollution remediation fields at different environmental conditions.
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- 2018
4. Phosphorus containing group and lignin toward intrinsically flame retardant cellulose nanofibril-based film with enhanced mechanical properties
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Wenzhu Li, Jingda Huang, Wenbiao Zhang, Qiang Wu, Qian Li, Shanshan Zhang, Siqun Wang, and Shi-Neng Li
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chemistry.chemical_classification ,Materials science ,Mechanical Engineering ,Chemical structure ,02 engineering and technology ,Polymer ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Industrial and Manufacturing Engineering ,0104 chemical sciences ,Solvent ,chemistry.chemical_compound ,chemistry ,Mechanics of Materials ,Ceramics and Composites ,Lignin ,Cellulose ,Composite material ,Elongation ,0210 nano-technology ,Layer (electronics) ,Fire retardant - Abstract
Cellulose-based film material, due to its remarkable physicochemical properties, environmentally friend and low cost, has been widely applied in many high-end areas. However, the lack of functional properties (e.g., flame resistance) except poor mechanical performance severely hinders their further applications. Herein, bamboo-based phosphorylated cellulose nanofibrils (B-PCNFs) were prepared through a simple two-step method composed of phosphorylation and mechanical grinding process. The resultant film prepared via solvent casting process shows an excellent mechanical strength of 115.9 MPa, remarkable elongation at break of 53.1%, high Young's modulus of 2.5 GPa and impressive work of fracture up to 41.8 MJ m−3, respectively, which should be contributed to the formation of dense and homogeneous polymer networks reinforced by enhanced multiple interactions. When burned against the flame of alcohol lamp (700–800 °C), BHL-PCNF film also delivers appealing structural stability even over 25s, demonstrating a prominent flame resistance. Meanwhile, compared to original one, the peak heat release rate (PHRR) and total heat released (THR) of BHL-PCNF film produce a dramatical reduction, i.e., 87.3% and 86.6% for PHRR and THR, respectively. Based on the evolution of morphological and chemical structure, the highly improved flame resistance is strongly contributed to the synergy of phosphorus containing group and lignin, resulting in a protective layer composed of PxOy compound and carbon layer. The proposed mechanism for the enhanced flame retardant property is also declared and clarified. Thereby, this phosphorylated cellulose-based film that integrates outstanding mechanical performance and excellent intrinsically flame resistance holds promising potential candidate in practical applications, such as flame-retardant packaging materials.
- Published
- 2021
5. Efficient interfacial interaction for improving mechanical properties of polydimethylsiloxane nanocomposites filled with low content of graphene oxide nanoribbons
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Shi-Neng Li, Long-Cheng Tang, Guo-Dong Zhang, Jing Zang, Li Zhao, Li-Zhi Guan, and Neng-Jian Huang
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chemistry.chemical_classification ,Materials science ,Nanocomposite ,Polydimethylsiloxane ,Graphene ,General Chemical Engineering ,Oxide ,chemistry.chemical_element ,02 engineering and technology ,General Chemistry ,Polymer ,Carbon nanotube ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,law.invention ,chemistry.chemical_compound ,chemistry ,law ,Ultimate tensile strength ,Composite material ,0210 nano-technology ,Carbon - Abstract
In this work, hydroxyl-terminated polydimethylsiloxane (H-t-PDMS) nanocomposites reinforced by different contents of graphene oxide nanoribbons (GONRs) were prepared via a facile solvent-free process, and the mechanical properties of the H-t-PDMS/GONR nanocomposites were investigated and compared with the corresponding nanocomposites containing pristine carbon nanotubes (CNTs) or functionalized CNTs (f-CNTs). It was found that the GONRs with abundant functional groups showed good compatibility with the H-t-PDMS matrix at appropriate content: both good dispersion levels of the GONR sheets and strong GONR/matrix interfacial interactions were achieved at low filler content (≤0.5 wt%), although the GONR sheets showed obvious clusters in the matrix at relatively high content. Mechanical testing indicated that the incorporation of a low content of GONRs into the H-t-PDMS polymer resulted in significant improvements in both the tensile and tear strengths, e.g. about 158 and 284% at 0.5 wt% GONRs, respectively; and such reinforcement efficiency of the GONRs in the PDMS nanocomposites was much better than those of the corresponding CNTs or f-CNTs, even superior to those of other carbon nanofillers in previous PDMS-based nanocomposite systems. Based on the morphology and fracture surface analysis, the possible reinforcing mechanisms were discussed and clarified to understand the discrepancies in the mechanical properties of the nanocomposite systems studied.
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- 2017
6. Facile and green synthesis of mechanically flexible and flame-retardant clay/graphene oxide nanoribbon interconnected networks for fire safety and prevention
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Zhi-Ran Yu, Long-Cheng Tang, Guo-Dong Zhang, Shi-Neng Li, Zhan-Jiang Zheng, Li Zhao, Qiao-Qi Xia, Cheng-Fei Cao, Min Mao, and Jiefeng Gao
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Materials science ,Graphene ,General Chemical Engineering ,Flame detection ,Oxide ,02 engineering and technology ,General Chemistry ,Polyethylene glycol ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Combustion ,01 natural sciences ,Industrial and Manufacturing Engineering ,0104 chemical sciences ,law.invention ,chemistry.chemical_compound ,Combustibility ,chemistry ,Chemical engineering ,law ,Ultimate tensile strength ,Environmental Chemistry ,0210 nano-technology ,Fire retardant - Abstract
Water-based hybrid graphene oxide nanoribbon (GONR)/montmorillonite (MMT)/polyethylene glycol (PEG) networks were prepared by using a facile bio-inspired low-temperature evaporation induced assembling process. Multiple non-covalent and covalent interactions together with a high orientation level of MMT were constructed in the hybrid PEG/MMT/GONR networks. As a result, the hybrid networks exhibit synergistic reinforcing and toughening efficiencies when compared with the composites modified with the single-phase filler, e.g. 152% and 167% increase in tensile strength for the optimized ternary composites in comparison with those of the binary composites. Moreover, the nacre-like hybrid networks show excellent flame resistance and structural stability in a flame due to the formation of interconnected and compact char after combustion, which can be applied as protective coatings to combustible materials. The hybrid coatings not only improve the flame-retardant property (e.g. ~46% decrease in heat release rate at 30 wt%) of the combustible PU foam materials significantly, but also provide ideal fire alarm responses (e.g. rapid flame detection of ~2 s and effective fire early warning signals in pre-combustion). Owing to the green and versatile synthesis scheme, excellent mechanical performance and flame resistance, these hybrid PEG/MMT/GONR networks are promising widespread application.
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- 2021
7. Constructing dual ionically cross-linked poly(acrylamide-co-acrylic acid) /chitosan hydrogel materials embedded with chitosan decorated halloysite nanotubes for exceptional mechanical performance
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Dechang Jia, Yang Li, Long-Cheng Tang, Yu Zhou, Zhi-Ran Yu, Baoqiang Li, Shi-Neng Li, Li-Xiu Gong, Yujie Feng, and Kun-Yu Guo
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chemistry.chemical_classification ,Toughness ,Nanocomposite ,Materials science ,Mechanical Engineering ,Nanoparticle ,02 engineering and technology ,Polymer ,engineering.material ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Halloysite ,Industrial and Manufacturing Engineering ,0104 chemical sciences ,Chitosan ,chemistry.chemical_compound ,chemistry ,Mechanics of Materials ,Ultimate tensile strength ,Self-healing hydrogels ,Ceramics and Composites ,engineering ,Composite material ,0210 nano-technology - Abstract
Hydrogels with exceptional mechanical properties at high water content are crucial need for practical applications in various fields. However, achieving a hydrogel possessed splendid mechanical performance with well trade-off between tensile strength and toughness is highly demanded due to the mechanical weakness of conventional hydrogel. Herein, we report a novel kind of nanocomposite hydrogel developed by integrating chitosan decorated halloysite nanotubes (CS-f-HNTs) into dual cross-linked structure composed of chemical and Fe3+ induced ionically cross-linked network. Combining the nanoparticle reinforcement with physical interactions including hydrogen bonds among polymer chains and ionic coordination interaction between Fe3+ ions and functional groups on chitosan chains and the copolymer chains, the hydrogel exhibits extraordinary and balanced mechanical performance, including high strength (3.06 MPa), outstanding stretchability (>2000%) and superior toughness (47.6 MJ m−3) in which water content remains ~80 wt%. Based on microstructure observation and dynamic mechanical behavior analysis, we demonstrated that the addition of CS-f-HNTs effectively bridged polymer chains via physical interactions and strengthened dual cross-linked network, leading to significant improved mechanical properties. Moreover, the hydrogels also possessed remarkable self-recoverability (97.9% for small strain (200%) and 91.5% for large strain (1000%)) at room temperature and the related mechanism was discussed. The strategy developed herein may provide a newfound avenue in the design and development of strong and tough hydrogel for promising applications in loading-bearing structural materials.
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- 2020
8. Chitosan in-situ grafted magnetite nanoparticles toward mechanically robust and electrically conductive ionic-covalent nanocomposite hydrogels with sensitive strain-responsive resistance
- Author
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Li-Xiu Gong, Yujie Feng, Zhi-Ran Yu, Long-Cheng Tang, Shi-Neng Li, Dechang Jia, Baoqiang Li, Yu Zhou, and Qiao-Qi Xia
- Subjects
Toughness ,Nanocomposite ,Materials science ,technology, industry, and agriculture ,General Engineering ,Nanoparticle ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Viscoelasticity ,0104 chemical sciences ,Chitosan ,chemistry.chemical_compound ,Electrical resistance and conductance ,chemistry ,Self-healing hydrogels ,Ceramics and Composites ,Composite material ,Deformation (engineering) ,0210 nano-technology - Abstract
Hydrogels with a combination of high mechanical properties and excellent electrical conductivity are promising for soft and wearable electronics devices. However, the trade-off between poor strength/toughness and high electrical resistance of the hydrogels severely hamper their practical application in diverse areas. In this work, we reported a facile and effective strategy for fabricating mechanically robust and electrically conductive nanocomposite hydrogels via incorporating chitosan in-situ grafted magnetite nanoparticles combined with multiple ionic-covalent interactions. The obtained nanocomposite hydrogel delivers a remarkable mechanical strength up to 2.33 MPa and high toughness of 18.18 MJ m-3 at a relatively high water content (80 wt%). Based on the creep/recovery experimental results and analysis (Burger's model and Weibull distribution function), the effect of multiple ionic-covalent interactions among the double-networks and chitosan in-situ grafted nanoparticles on the viscoelastic behavior of the hydrogel was discussed and clarified. In addition, the resultant nanocomposite hydrogel exhibits sensitive strain-induced resistance change under both compressive and tensile stress as well as outstanding stability and repeatability, which can accurately and repeatedly monitor both large mechanical deformation (e.g. tensile strain up to 600%) and human behaviors (e.g., motions of joints and facial expressions). This study offers a new scenario to design and develop a mechanically robust hydrogel with sensitive strain-responsive resistance, showing potential applications in electric skin, motion detection, wearable electronics, etc.
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- 2020
9. Enhanced mechanical property and flame resistance of graphene oxide nanocomposite paper modified with functionalized silica nanoparticles
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Long-Cheng Tang, Pingan Song, Guo-Dong Zhang, Shi-Neng Li, Li Zhao, Li-Xiu Gong, Ming Zhang, Zhi-Ran Yu, and Jing Zang
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Toughness ,Materials science ,Nanocomposite ,Graphene ,Mechanical Engineering ,Oxide ,Nanoparticle ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Silane ,Industrial and Manufacturing Engineering ,0104 chemical sciences ,law.invention ,chemistry.chemical_compound ,chemistry ,Mechanics of Materials ,law ,Ultimate tensile strength ,Ceramics and Composites ,Thermal stability ,Composite material ,0210 nano-technology - Abstract
Graphene oxide (GO) paper with outstanding integrated multiple functionalities (good mechanical performance, thermal stability and flame resistance, etc.) is strongly needed for numerous potential applications in cutting-edge fields. In this work, we report a facile and green process to fabricate GO-based nanocomposite papers via introducing functionalized silica (f-SiO2) nanoparticles. The results reveal that addition of f-SiO2 produces simultaneous improvements in mechanical strength, stiffness and flame resistance for GO paper. With incorporation of 10 wt% f-SiO2, the tensile strength, elastic modulus and toughness of the GO/f-SiO2 nanocomposite papers can be increased by about 51%, 317%, and 69%, respectively. Various characterizations disclose that hydrogen bonds and covalent interactions between GO sheets and f-SiO2 mainly contribute to the effective load transfer and energy dissipation between them, and thus leading to the improvements of mechanical properties. Based on the structural observation and analysis, the improved flame resistance of the GO/f-SiO2 papers should be attributed to the formation of rGO/SiO2 protective char, which are derived from the decomposition and redeposition of the grafted silane molecules and inorganic SiO2 and thermal reduction of GO into rGO. Our results suggest that the mechanical and thermal properties of GO papers can be tuned by introducing inorganic/organic f-SiO2, providing a new route for the rational designing and development of mechanically flexible and flame-retardant GO-based nanocomposite paper materials.
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- 2019
10. DFT investigations on the structure and properties of MBP dimers and crystal with strong hydrogen-bonding interactions
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Hui Yang, Lin Jianguo, Qingzhu Liu, Shi-Neng Luo, Xue-Hai Ju, Tengfei Wang, Ling Qiu, and Yang Wang
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Lattice energy ,Hydrogen bond ,Dimer ,Intermolecular force ,Interaction energy ,Condensed Matter Physics ,Gibbs free energy ,Crystallography ,chemistry.chemical_compound ,symbols.namesake ,chemistry ,symbols ,Density functional theory ,Physical and Theoretical Chemistry ,Electronic band structure - Abstract
Theoretical studies on the monomers, dimers, and crystal of the prototypical bisphosphonic acid, methylenebisphosphonic acid (MBP), were performed at different density functional theory levels. The hydrogen bonding, interaction energy, thermodynamic property, lattice energy, and electronic structure were investigated. Five stable dimers were identified through the intermolecular hydrogen-bonding interaction, and the stability order was estimated by the interaction energies. For the most stable dimer, the interaction energy is −170.86 kJ/mol at the M06-2X/6-311++G** level, while that for the least stable dimer is −46.74 kJ/mol. At 298.15 K, the changes of Gibbs free energies (∆G) for the dimerization processes of five dimers are all negative (−122.72, −85.09, −8.46, −114.02, and −100.70 kJ/mol), suggesting these dimers can be spontaneously produced from the isolated monomer at room temperature. The stability order of dimers derived from the ∆G T values agrees well with that determined by the interaction energies. The lattice energy for the crystalline MBP was predicted to be −828.90 and −899.79 kJ/mol by GGA/PBE and GGA/PW91, respectively, whereas it was overestimated by LDA/CA–PZ (−1319.72 kJ/mol). The band structure calculations indicate that MBP is a wide-gap insulator with a band gap of more than 6.0 eV. The charge distribution and bonding overlap populations show that the bond strength of O–H is less than other bonds due to taking part in the formation of intermolecular hydrogen bonds.
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- 2015
11. Substituent Effect on the Structure and Biological Property of99mTc-Labeled Diphosphonates: Theoretical Studies
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Jianguo Lin, Ling Qiu, Shi-Neng Luo, Xue-Dong Gong, and Wen Cheng
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chemistry.chemical_compound ,Computational chemistry ,Chemistry ,Biological property ,Computation ,Diphosphonates ,Structure (category theory) ,Substituent ,Density functional theory ,General Chemistry ,Electron ,Science, technology and society - Abstract
Institute for Computation in Molecular and Material Science, School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, P.R. ChinaReceived May 24, 2012, Accepted September 21, 2012Theoretical calculations based on density functional theory (DFT) were performed to study the substituenteffect on the geometric and electronic structures as well as the biological behavior of technetium-99m-labeleddiphosphonate complexes. Optimized structures of these complexes are surrounded by six ligands in anoctahedral environment with three unpaired 4d electrons ( d
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- 2012
12. Synthesis and evaluation of fluoroethyl cyclofenil analogs: Models for potential estrogen receptor imaging agent
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Shi-Neng Luo, Hua Zhu, Yu-Mei Shen, Jian-Guo Lin, and Zhi Yang
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medicine.medical_specialty ,Biodistribution ,medicine.diagnostic_test ,Mesylate ,Organic Chemistry ,Uterus ,Estrogen receptor ,Biochemistry ,Imaging agent ,Inorganic Chemistry ,chemistry.chemical_compound ,medicine.anatomical_structure ,Endocrinology ,chemistry ,Positron emission tomography ,Internal medicine ,medicine ,Environmental Chemistry ,Physical and Theoretical Chemistry ,Cyclofenil ,Fluoroethyl - Abstract
Cyclofenil analogs (2a–2f) and their fluorine-containing derivatives (3a–3f) were synthesized and evaluated as candidate ligands for positron emission tomography (PET) imaging of estrogen receptors. Most of them show relatively high binding affinities comparable with estradiol (E2). (4-Fluoroethoxyphenyl)-(4-hydroxyphenyl) methylenecyclopentane (3a) showed both the highest binding affinity for ERs (88.6 for ERβ, 13.8 for ERα) and highest β/α ratio (β/α for 6.4-fold). The radioactive compound [18F]3a was prepared via displacement of the corresponding mesylate precursor 4 with [18F]fluoride (18F: β+; 96.7%, T1/2 = 109.8 min). The biodistribution studies in immature female SD rats demonstrated that the uptake in the uterus and ovaries were 1.358 ± 0.089% ID/g, 1.439 ± 0.214% ID/g, respectively, both of the ratios of uterus/blood and ovaries/blood was less than 2:1. Micro-PET imaging of immature female SD rats has also been reported.
- Published
- 2012
13. Identification of natural compounds with antiviral activities against SARS-associated coronavirus
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Xiang Zhang, Hai Yan Guo, Pei-Gen Xiao, Cong Chen, Rongsong Li, Hui Wang, Jun Yu, Shi You Li, Xuehai Tan, Haiqing Zhang, Shi Neng Hua, and Lin Wang
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Lycoris radiata herb ,Drug Evaluation, Preclinical ,Tetrazolium Salts ,Microbial Sensitivity Tests ,Pharmacology ,medicine.disease_cause ,Lycorine ,Antiviral Agents ,Article ,Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) ,law.invention ,Cell Line ,chemistry.chemical_compound ,Cytopathogenic Effect, Viral ,law ,Virology ,Chlorocebus aethiops ,medicine ,Liliaceae ,Coronaviridae ,Animals ,Humans ,Cytotoxicity ,Vero Cells ,Cytopathic effect ,Coronavirus ,EC50 ,Natural products ,biology ,biology.organism_classification ,Phenanthridines ,Lycoris radiata ,chemistry ,Drug screening ,Severe acute respiratory syndrome-related coronavirus ,Amaryllidaceae Alkaloids ,Phytotherapy ,Drugs, Chinese Herbal - Abstract
More than 200 Chinese medicinal herb extracts were screened for antiviral activities against Severe Acute Respiratory Syndrome-associated coronavirus (SARS-CoV) using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium inner salt (MTS) assay for virus-induced cytopathic effect (CPE). Four of these extracts showed moderate to potent antiviral activities against SARS-CoV with 50% effective concentration (EC50) ranging from 2.4 +/- 0.2 to 88.2 +/- 7.7 microg/ml. Out of the four, Lycoris radiata was most potent. To identify the active component, L. radiata extract was subjected to further fractionation, purification, and CPE/MTS assays. This process led to the identification of a single substance lycorine as an anti-SARS-CoV component with an EC50 value of 15.7 +/- 1.2 nM. This compound has a CC50 value of 14980.0 +/- 912.0 nM in cytotoxicity assay and a selective index (SI) greater than 900. The results suggested that four herbal extracts and the compound lycorine are candidates for the development of new anti-SARS-CoV drugs in the treatment of SARS.
- Published
- 2005
14. In vivo pharmacokinetics comparisons of icariin, emodin and psoralen from gan-kang granules and extracts of herba Epimedii, Nepal dock root, Ficus hirta yahl
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Bo Li, Ting-ting Guo, Shi-Neng Yan, Yan-qin Zhou, Yihui Li, Yu-Xiang Chen, Ju-Ping Duan, and Wei Xie
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Quality Control ,food.ingredient ,Emodin ,Pharmacognosy ,Berberidaceae ,chemistry.chemical_compound ,food ,Drug Stability ,Drug Discovery ,Medicine ,Animals ,heterocyclic compounds ,Rumex ,Psoralen ,Chromatography, High Pressure Liquid ,Pharmacology ,Epimedium ,Flavonoids ,Traditional medicine ,biology ,business.industry ,Plant Extracts ,Ficusin ,Reproducibility of Results ,Drug Synergism ,Reference Standards ,biology.organism_classification ,Ficus ,Bioavailability ,Rats ,chemistry ,Herb ,Calibration ,Spectrophotometry, Ultraviolet ,business ,Icariin ,Drugs, Chinese Herbal - Abstract
Ethnopharmacological relevance Gan-kang granules (GKG) contains the extracts from eight Chinese herbs and is a traditional Chinese composite prescription for treatment of hepatitis B. Icariin, emodin and psoralen are main effective ingredients of the medicine. Aim of the study In this research, pharmacokinetic comparisons of icariin, emodin and psoralen from the extracts of Herba Epimedii, Nepal dock root and Ficus hirta yahl, and GKG were conducted. Materials and methods At different time points (0.25, 0.5, 0.75, 1, 1.5, 2, 4, 6, 8, 12 and 24 h) after administration, the concentrations of icariin, emodin and psoralen in rat plasma were determined by HPLC-UV, and main pharmacokinetic parameters were estimated. Results The pharmacokinetic parameters of icariin, emodin and psoralen in GKG were elevated comparing with those of herb extracts. Conclusions Three HPLC-UV methods were developed successfully for the analysis of icariin, emodin and psoralen in SD rat plasma. Some ingredients in GKG may increase the dissolution and absorption, and improve bioavailability of icariin, emodin and psoralen in rats.
- Published
- 2008
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