1. Bio-evaluation of fluoro and trifluoromethyl-substituted salicylanilides against multidrug-resistant S. aureus
- Author
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Abdul Akhir, Grace Kaul, Shabina B. Ansari, Jhajan Lal, Sidharth Chopra, and Damodara N. Reddy
- Subjects
Vancomycin-resistant Staphylococcus aureus ,medicine.drug_class ,Antibiotics ,Drug repurposing ,Fluorosalicylanilides ,medicine.disease_cause ,Microbiology ,Trifluoromethyl salicylanilides ,chemistry.chemical_compound ,medicine ,General Pharmacology, Toxicology and Pharmaceutics ,Original Research ,Chemistry ,Biofilm ,Organic Chemistry ,Multidrug-resistant S. aureus ,medicine.disease ,Antimicrobial ,Methicillin-resistant Staphylococcus aureus ,Multiple drug resistance ,Salicylanilide ,Antibacterial ,Staphylococcus aureus ,Vancomycin ,Drug synergism ,medicine.drug - Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Staphylococcus aureus (VRSA) are primary causes of skin and soft tissue infections worldwide. To address the emergency caused due to increasing multidrug-resistant (MDR) bacterial infections, a series of novel fluoro and trifluoromethyl-substituted salicylanilide derivatives were synthesized and their antimicrobial activity was investigated. MIC data reveal that the compounds inhibited S. aureus specifically (MIC 0.25–64 µg/mL). The in vitro cytotoxicity of compounds with MIC
- Published
- 2021