1. Cu-catalyzed arylation of 1-acyl-1H-1,2,3-Benzotriazoles via C–N activation
- Author
-
Yangyang Wang, Wenying Zhang, Ying Fu, Zhengyin Du, and Xiangru Jia
- Subjects
Reaction mechanism ,010405 organic chemistry ,Organic Chemistry ,chemistry.chemical_element ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Medicinal chemistry ,0104 chemical sciences ,Catalysis ,Inorganic Chemistry ,chemistry.chemical_compound ,chemistry ,Product (mathematics) ,Yield (chemistry) ,Caesium ,Materials Chemistry ,Carbonate ,Physical and Theoretical Chemistry - Abstract
An efficient copper-catalyzed arylation reaction of 1-acyl-1H-1,2,3-benzotriazoles with diaryliodonium salts via C–N activation is explored. The reaction is conducted regioselectively to form 1-aryl-1H-1,2,3-benzotriazoles in MeCN at 80 °C in the presence of cesium carbonate. 29 examples are given with the product yield of up to 84%. The probable reaction mechanism is proposed.
- Published
- 2019