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Three mixed ligand complexes of copper(II) with adenine and dicarboxylic acids have been synthesized. The resulting complexes were characterized by their melting point, solubility, metal content analysis, FT-IR and UV-visible spectroscopy, magnetic measurement, thermal analysis, cyclic voltammetric measurement and X-ray powder diffraction study. The products are microcrystalline powder, slightly soluble in water and decompose at high temperature. Under experimental condition, the ligands adenine (Ade) behaves as a neutral ligand, whereas oxalic acid (OxH2), succinic acid (SucH2) and tartaric acid (TarH2) are doubly deprotonated to form dianionic ligands that are coordinated to the Cu(II) ion. The Cu(II) content analysis of the complexes confine to their stoichiometry [Cu(Ade)(L)(H2O)] (L = Ox, Suc, or Tar dianion). Electrochemical redox behavior of the complexes in their reaction medium was also examined. They exhibit quasi-reversible one-electron transfer processes. Dhaka Univ. J. Sci. 69(2): 76-81, 2021 (July)

The effectiveness of the use of mixed ligand complexes of Zinc, Manganese and Cobalt in the diets of high-yielding cows in the final period of lactation, and their effect on productivity, nutrients digestibility and nitrogen metabolism in the animals’ body was studied in a scientific economic experiment conducted at the Terezyne Ltd. of Bila Tserkva district, Kyiv region. Five groups of highly productive cows of Holstein, Ukrainian red-spotted and Ukrainian black-spotted dairy breeds were selected on the principle of analogues. The difference in feeding cows of the groups was in the following: - the diet of the control 1st group was balanced to the norm only with trace elements of Selenium, Copper and Iodine. - cows of the 2nd and 3d experimental group were fed with the norm of all trace elements (for the 2nd experimental groupthe norm was provided due to introducing sulfates of Zinc, Manganese, Cobalt, Copper, Selenium Suplex and Potassium iodide; for the 3d experimental group , sulfates of Zinc, Manganese and Cobalt were substituted with their mixed ligand complexes). - for cows of 4th experimental group, the concentration of Zinc, Manganese and Cobalt in 1 kg of dry matter feed was reduced by 11% compared to the group 3. - for the 5thgroup it was 22% lower than in the group 3. The results of the studies show that the use different doses of mixed ligand complexes of Zinc, Manganese, Cobalt in cows feeding with the use of Selenium Suplex, Copper sulfate and Potassium iodide during the final 100 days of lactation did not affect milk productivity. Each cow of the control group in the final period of lactation yielded 2220 kg of natural milk, whereas the cows of the experimental groups 2-5 yielded 40-120 kg more. The difference in the average daily milk yield of 4% fat was 0.5–1.91 kg, and this difference was significant (p

The results of establishing the optimal feeding doses of Zinc, Manganese, and Cobalt in the form of their mixed-ligand complexes for high-yielding cows of Holstein, Ukrainian Red-Spotted and Ukrainian Black-Spotted dairy breeds during the late dry period were presented, their influence on the future productivity and reproductive qualities of cows were also determined. It was found that lower doses of mixed-ligand complexes of Zinc, Manganese, and Cobalt in the feed mixture stimulated its consumption better. The cows of the 4th experimental group consumed more of the feed mixture, where the concentration of Zinc and Manganese was 35 mg, and Cobalt – 0.49 mg per 1 kg of DM. At various doses of mixed-ligand complexes of Zinc, Manganese, and Cobalt, the increase in live weight in cows of the control group was 24.3 kg, and in the experimental groups, it ranged from 23.7 kg to 26.9 kg, which is 8.6% and 10.7% (P < 0,05) more in the 3rd and 4th groups compared with the control. A decrease in the concentration of mixed-ligand complexes of Zinc, Manganese, and Cobalt in the diets of dry cows in the experimental groups by 10, 20, 30 and 40% had a positive effect on their further milk productivity. During the first 100 days of lactation, they milked 60-180 kg of milk more compared to the control with an increase in fat content by 0.01–0.05%. Also, in the milk of experimental group’s cows, compared with the control, the protein content increased (3.22–3.23% versus 3.14%), and the feed costs per 1 kg of milk in them were lower by 3.5–9.4%. Smaller doses of zinc, manganese, and cobalt contributed better to lengthening the period of prolonged action of their mixed-ligand complexes on the body of lactating cows. The calves’ live weight at the birth in the 4th experimental group exceeded the indicator of their peers from the control group by 2.3 kg or 8.81%, while the calves obtained from cows of the 2nd experimental group prevailed the control by 1.6 kg, or 6, 13 %, from the 3rd experimental group – by 1.8 kg, or 6.90%, and the 4th experimental group – by 1.7 kg, or 6.51%. The duration of the service period in all experimental groups of cows was within the recommended norms and was 87.8 days in the control group, and the 2nd, 3rd, 4th and 5th experimental groups, respectively 84.7 days, 82.2; 80.6 and 83.5 days, respectively, and there was less in control by 3.1–7.1 days or 3.3–8.2%. The insemination index in the cows’ control group was 1.5, and in the experimental one – 1.2–1.4, which is 6.7–20.0% less.

The article deals with the results of research to study the digestibility of nutrients in the ration and metabolism of Nitrogen, Zinc and Manganese in high-yielding Holstein cows of German selection in the first period of lactation for feeding mixed ligand complexes of Zinc, Manganese and Cobalt. The research was performed in the conditions of Terezyne Ltd., Bila Tserkva district, Kyiv region. There was an increase in the coefficients of digestibility of dry matter in cows of the 2nd-5th experimental groups compared with animals of the 1st control group, respectively by 1.8–3.5 % (P < 0.05); organic matter by 0.3–2.5 %; crude protein by 0.5–4.2 % (P < 0.05 – P < 0.01); crude fat by 1.1–1.8 %; crude fiber by 1.3–3.3 % and nitrogen-free extractives by 2.1–4.2 %. Cows of the experimental groups consumed more Nitrogen than the cows of the control group: 20.18 g or 2.4 % – the 2nd group, 55.06 g or 6.6 % – the 3rd, 42.52 g or 5, 1 % – 4th and 28.98 g or 3.5 % – 5th experimental group due to better eating of the feed mixture. General consumption level of Nitrogen in relation to excreted with milk and deposited in the body of cows of the control group was 32.02 %, and in animals of the 2nd, 3rd, 4th and 5th experimental groups – 33.59 %; 37.31; 36.99 and 34.97 %. In relation to the total digested amount, the proportion of Nitrogen deposited in the body and excreted with milk in animals of the control group was 42.38 %, and in the experimental – 44.25–47.34 %. Doses of Zinc, which provided its existing rate of 54–85 % due to the mixed ligand complex, positively influenced on the the metabolism of trace elements in the organism of experimental cows. Assimilation of Zinc in the organism was determined by the amount of its secretions with milk and deposits in the body and in absolute terms it was the lowest in cows of the 4th and 5th experimental groups – 562.7 mg and 671.6 mg against 740.8 mg in the 1st control group and the largest – 784.7 mg and 801.3 mg in animals of the 2nd and 3rd experimental groups. The use of a mixed ligand complex of manganese ensured its positive balance in the organism of cows and the absorption of the trace element in the organism of experimental cows ranged from 22.5 % in the 2nd experimental group to 33.2 % in the 3rd experimental group. The best indicators for the metabolism of Nitrogen, Zinc and Manganese were got in the third experimental group whose cows were fed a feed mixture, that in 1 kg of DM contained, mg: Zinc – 54.7; Manganese – 54.7; Cobalt – 0.7; Selenium – 0.3; Copper – 12 and Iodine – 1.1.

New mixed-ligand heteronuclear complexes of lanthanum and cobalt (nickel) with acetylacetone (НАА) and α,α'-dipyridyl were synthesized and investigated by physic-chemical methods of analysis (eleme...

Metformin is one of the most effective drugs for the treatment of type II diabetes. Two new mixed ligand complexes of vanadyl(ii) and chromium(iii) ions with the general formula [VOL1L2]SO4 and [CrL1L2(Cl)2]Cl, respectively, where L1 is the metformin and L2 is the glycine amino acid, have been synthesized in MeOH solvent with 1:1:1 stoichiometry and characterized by several spectroscopic techniques. The spectroscopic data suggested that the [VOL1L2]SO4 complex possesses a square pyramidal geometry, where the [CrL1L2(Cl)2]Cl complex possesses an octahedral geometry. The L1 ligand coordinated to the VO(ii) and Cr(iii) ions via the N atoms of the imino (‒C═NH) groups, where the L2 ligand coordinated via the O atom of the carboxylate group (COO) and the N atom of the amino group (NH2). The interaction of ligands L1 and L2 with the metal ions leads to complexes that have organized nanoscale structures with a main diameter of ∼14 nm for the [CrL1L2(Cl)2]Cl complex and ∼40 nm for the [VOL1L2]SO4 complex.

The Co2+–triglycine–L-histidine system is studied in an aqueous solution at Т = 298.15 K (KNO3) via potentiometry and calorimetry. The formation of mixed-ligand CoL2Y− complex is established, and the standard thermodynamic characteristics (ΔrH°, ΔrG°, ΔrS°) of the complexation reaction are determined. A structure is proposed for this complex.

The spectral-luminescent properties of europium(III) complexes with o-methoxybenzoic acid and phosphorus-containing neutral ligands with an island structure and the compositions Eu(MOBA)3 · 3H2O and Eu(MOBA)3 · L, where MOBA is o-methoxybenzoic acid and L is hmpa (hexamethylphosphortriamide, tppo (triphenylphosphinoxide), and Et6pa (hexaethylphosphortriamide), are studied. It is found that the excitation energy transfer to the europium ion occurs from the levels of both o-methoxybenzoic acid and phosphorus-containing neutral ligands. The electronic absorption and luminescence excitation spectra, as well as the Stark structure of the 5D0−7Fj ( j = 0–2) electronic transitions in the luminescence spectra of mixed-ligand complexes of europium(III) o-methoxybenzoates, are analyzed. The highest luminescence intensity is demonstrated by europium(III) methoxybenzoate with triphenylphosphinoxide.

Luminescent coordination mixed-ligand compounds of europium(III) with ortho-methoxybenzoic acid and phosphorus-containing neutral ligands of the isle-like structure Eu(MOBA)3 · 3H2O and Eu(MOBA)3 · L have been synthesized. MOBA—ortho-methoxybenzoic acid, L—hmpa (hexamethylphosphotriamide), tppo (triphenylphosphinoxide), Et6pa (hexaethylphosphotriamide). Thermal properties of the complex mixed-ligand compounds of europium(III) have been investigated. It has been shown that thermolysis results in the splitting of a neutral ligand molecule proceeding within one stage along with an endothermic effect. The complex compound appeared to be stable up to 280°C. The composition and structure of the synthesized complexes have been established. Based on the IR spectroscopy data, it has been demonstrated that in ortho-methoxybenzoates of europium(III) ortho-methoxybenzoic acid is coordinated to a europium(III) ion bidentately.

Розроблені методики прямого спектрофотометричного визначення загального флуору у продуктах для гігієни порожнини рота з використанням змішанолігандного комплексу La(III) та алізарин-комплексону з флуоридйонами у присутності нейонної поверхнево-активної речовини. Встановлено, що у системі утворюється ряд комплексів різної стехіометрії та показано, що як аналітичну форму доцільно використовувати комплекс складу La:алізарин-комплексон:, який у присутності Tween 80 характеризується молярним коефіцієнтом поглинання ε620 = 11000 моль·дм-3 ·см -1. Показано, що калібрувальний графік є лінійним в діапазоні концентрацій флуорид-йонів 0,06–0,5 мкг/мл. Запропоновано просту, швидку та чутливу методику для спектрофотометричного визначення Fз використанням алізарин-комплексонату лантану в присутності Tween 80, яку було апробовано на зразках зубних паст та ополіскувачах ротової порожнини. A technique for direct spectrophotometric determination of total fluorine in products for oral hygiene using a mixed ligand complex La(III) and alizarincomplexone with fluoride ion in the presence of a non-ionic surfactant has been developed. A number of complexes of different stoichiometry formed in the system has been found. The La:alizarin-complexone:F= 1:2:1 complex was shown to be used as an analytical form. The complex in the presence of Tween 80 is characterized by the molar absorptivity ε620 = 11000 mol∙dm-3 ∙cm -1. The calibration curve is linear in the concentration range of fluoride ions 0.06–0.5 μg/ml. A simple, rapid, sensitive, and green procedure for the spectrophotometric determination of Fusing lanthanum alizarin-complexonate in the presence of Tween 80 was proposed and this technique was tested on samples of toothpastes and mouth rinses.

Синтезовано нові координаційні сполуки купруму(II) із заміщеними тіоамідами загальної формули [Сu(HL6-9)2X2]2 та CuL2 6-9. Досліджено реакції послідовного нуклеофільного заміщення/елімінування SN 1/E1 в октаедричному комплексі [Сu(NH3)4Cl2]∙H2O та каталітичного гідролізу комплексів [Сu(HL6-9)2X2]2. На основі даних елементного та рентгеноструктурного аналізу, ІЧ-спектроскопії встановлено склад і будову синтезованих комплексів. Молекулярну і кристалічну структуру комплексу [Cu(C30H26Cl2N6O8S2)]·iC3H7OН встановлено методом рентгеноструктурного аналізу. Досліджено триботехнічні характеристики (Іg, fтр) деяких координаційних сполук як додатків до індустріальних олив. New coordination compounds of copper(II) with substituted thioamides of the general formula [Cu(HL6-9)2X2]2 and CuL2 6-9 have been synthesized. The consecutive reaction of nucleophilic substitution/elimination of SN 1/E1 in the octahedral complex [Cu(NH3)4Cl2]·H2O and catalytic hydrolysis of [Cu(HL6-9)2X2]2 complexes have been investigated. Using IR spectroscopy, elemental and XRD analysis, the composition and structure of the synthesized complexes have been determined. The molecular and crystalline structure of the complex [Cu(C30H26Cl2N6O8S2)]·iC3H7ON was determined by X-ray diffraction analysis. The tribotechnical characteristics of some coordination compounds as additives to industrial oils have been investigated.

Mixed ligand complexes of copper(II) and nickel(II) with glycine (Gly) and histidine (His) have been studied in aqueous solution using calorimetric, potentiometric and spectrophotometric data at 298.15 K and the ionic strength of I = 0.5 mol·L–1 (KNO3). The thermodynamic parameters of formation of various mixed complexes have been determined. The probable coordination modes of amino acid residues in mixed ligand complexes is discussed.

New mixed ligand complexes of nickel(II) were synthesized by using dibasic H/5-bromo-/5-chloro-/4-hydroxy-2-hydroxybenzophenone-thiosemicarbazones (L1–4H2) and [Ni(PPh3)2Cl2]. The ligands and complexes were characterized by cyclic voltammetry, infrared, 1H and 31P NMR spectroscopy techniques. Crystallographic analyses of the 5-bromo-substituted (2) and 5-chloro-substituted (3) complexes as representatives were performed and so confirmed the ONS chelate structure and presence of PPh3 as co-ligand in the complexes. To reveal the antioxidant properties of the compounds, TEAC values (by CUPRAC method) were determined along with free radical-scavenging activity (by DPPH method). The compounds bearing 4-hydroxy substituent, L4H2 and complex 4 were the most effective compounds. The relationship between structure and antioxidant capacity in the context of benzophenone substituents and nickel(II) center was evaluated. Electrochemical results revealed that all complexes displayed metal-centered and ligand-centered redox processes. The antioxidant capacities of complexes were well correlated to electrochemical parameters.

Zirconium(II) and palladium(II) mixed ligand metal complexes were synthesized by using an equimolar mixture of tetracycline (Tc) as primary ligand and salicylaldehyde as secondary ligand. The metal complexes were characterized by physico-chemical and spectroscopic techniques like CHN analysis, surface tension, pH, conductivity and melting point measurements. The spectroscopic characterization technique includes IR, (1H & 13C) NMR, UV/visible and Mass spectrometry methods. The SEM technique determines the surface morphology of the complexes. The thermal and kinetic stability of the complexes was obtained from TGA/DTA curves from which the parameters like E*, ΔH*, ΔS* and ΔG* have been calculated by using the Coats-Redfern equation. Molecular modeling gives a geometry of the complex which was obtained from Chem 3D Pro. 12.0 software program. The metal complexes of Zr-TcSal and Pd-TcSal have coordinated with tetrahedral and square planar geometry, respectively. The antibacterial susceptibility study of the synthesized metal complexes was done by Kirby-Bauer paper disc diffusion techniques on S. aureus, E. coli and P. aeruginosa clinical pathogens

A new cationic mixed-ligand complex [Lа(L)2bipy2]BPh4 (where L-= bis(N,N'-diethylamide)(N'-trichloroacetyl)-triamidophosphate anion, bipy = 2,2'-bipyridine) has been synthesized and studied by the means of IR, 1H NMR spectroscopy, thermogravimetric and X-ray structural analyses. Low-frequency shifts of the absorption bands of the carbonyl and phosphoryl groups of phosphorylated ligand in the IR spectra of the complex compared with similar absorption bands in the spectrum of "free" CAPh ligand are Δν(C = O) = 117 cm–1 and Δν(P = O) = 137 cm–1. The analysis of integral signal intensity in the investigated NMR spectra of coordination compounds [Lа(L)2bipy2]BPh4 indicates the molar ratio of ligand : bipyridine : tetraphenylborate anion as a 2:2:1, which corresponds to the proposed structure of the complexes. The compound has been obtained in monocrystalline form. The structure of the complex has been determined by X-ray structural analysis, its ionic structure was proved, and the coordination of two CAPh ligands through the oxygen atoms of the carbonyl and phosphoryl groups was confirmed. Based on the structural data, it was determined that the La3+ ion is octocoordinated (surrounded by four oxygen atoms from two chelated phosphoryl ligands and four nitrogen atoms from two 2,2'-bipyridine molecules). The coordination polyhedron of central ion is interpreted as a square antiprism. Complex cations and tetraphenylborate anions are connected both by electrostatic interaction and by weak intermolecular C – H ∙∙∙ π-contacts between phenyl substituents of BPh4- and molecules of 2,2'-bipyridine. It was established by thermogravimetric analysis that the complex [Lа(L)2bipy2]BPh4 obtained is thermally stable up to a temperature of 150 °C. Significant decomposition of the complex begins at a temperature of 150 °C, occurs in one stage and most intensively continues up to 300 °C. The total weight loss is 78 %.

Pd(TMPDA)Cl2 (TMPDA = N,N,N`,N`-tetramethyl-1,3-propanediamine) was synthesized and characterized by elemental analysis. [Pd(TMPDA)(H2O)2]2+ reacts with amino acid esters (L) to form mixed ligand [Pd(TMPDA)L]2+ complexes. The kinetics of base hydrolysis of [Pd(TMPDA)L]2+ was studied by pH-stat technique and the corresponding rate constants are reported. The coordinated glycine methyl ester is efficiently hydrolyzed, whereas the coordinated methionine methyl ester is hydrolysed with a much lower catalytic activity. The catalytic influence is depended on the mode of coordination of the ester to the palladium complex. Probable mechanisms for these reactions are considered. Activation parameters for the hydrolysis of the coordinated glycine methyl ester were determined experimentally. DFT calculations (B3LYP/LANL2DZ) were applied to determine the possible mechanism of the base hydrolysis of the amino acid esters. The calculations are discussed in reference to the reported experimental data.

Five compounds 2-(2-Hydroxybenzylidene)-N-(prop-2-en1-yl)hydrazinecarbothioamide (H2L), bis[μ2-2-({2-[(prop-2-en-1-yl) carbamothioyl] hydrazinylidene}methyl) phenolatoS,N,O:O] diaquadicopper (II) nitrate (1), bis [μ2-2-({2-[(prop-2-en-1-yl) carbamothioyl] hydrazinylidene}methyl)phenolato-S,N,O:O]d iimidazoldicopper(II) nitrate (2), bis[μ2-2-({2-[(prop-2en-1-yl)carbamothioyl]-hydrazinylidene}methyl)phenolato-S,N,O:O]bis-(3,5-dibromopyridine)dicopper( II) nitrate hexahydrate (3), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]-hydrazinylidene}methyl) phenolato-S,N,O:O]bis(4-methylpyridine)dicopper(II) nitrate hexahydrate (4) were synthesized. The antiproliferative properties of these compounds towards cancer cell lines HeLa, RD and normal cell line MDCK have been investigated. The tested compounds demonstrated high antioxidant and antiproliferative, selective activities towards cancer cells. Direct toxic evaluation of compounds was performed by Daphnia magna bioassay.

The combined use of P(2-MeOC6H4)3 (L1) and TMEDA as ligands effectively prevents defect formation in palladium-catalyzed direct arylation polymerization (DArP) to give donor–acceptor type alternati...

A series of Chloro-arsenic(III) complexes with N, O donor β-ketiminate ligand (L1) and S, S donor piperidine dithiocarbamate ligand (L2) have been synthesized by the reactions of AsCl3 with both ligands in equimolar ratio by stirring at room temperature in benzene solution. All these synthesized compounds have been characterized by Elemental Analysis, IR, (1H and 13C) NMR Spectral and ESI-Mass Studies. Both Ligands and their corresponding Chloro-arsenic (III) complexes have been screened for antimicrobial activity against the various bacterial (E. Coli, B. Subtalis and P. Aeruginosa) and fungal (T. Resei, P. Funiculosum and Fusarium) strains and results obtained .

The formation constants of various complexes of copper(II) with anti-inflammatory drug piroxicam (P) as primary ligand and some bioligands such as L-serine, L-tyrosine, L-threonine as secondary ligand have been determined pH metrically at 25 ºC and I = 0.1 M NaNO3. The results suggest that the formation of Cu(P)L and Cu(P)(LH-1) species in the pH range of 5-12. The values of Δ log10 K, percentage of relative stabilization and log X were evaluated and discussed.

The interaction of triethanolamine (TEA) with Cu(II) salts of salicylic, cinnamic and succinic acids was studied for the first time. The structure of the synthesized complexes was investigated by single-crystal X-ray diffraction. TEA complexes with Cu(II) salicylate (1) and cinnamate (2) are binuclear mixed ligand complexes, but interaction of TEA with Cu(II) succinate leads to the formation of cationic mononuclear complex—[Cu(TEA)2](C4H4O4) (3). Cu(II) complexes 1–3 were also characterized by physicochemical and spectroscopic methods. Their antimicrobial activity was investigated.

Digestibility of the feed nutrients and the chemical elements balance in broiler chickens were studied under use of mixed feed with sulfate and Zink-mixed ligand complex in the physiological experiment that was conducted in the vivarium of the Bila Tserkva National Agrarian University. A tendency to increase the level of feed nutrients digestibility in the experimental groups of broiler chickens consuming mixed fodders with Zinc-mixed ligand complex was revealed in the conducted experiment. The nutrients digestibility indices were the highest in the chickens of the experimental group 3 where Zink-mixed ligand complex was added to the mixed feed. 45, 37.5 and 30 g of the element was added per 1 ton of mixed feed, respectively, for the growing period of 5-21, 22-35 and 36-42 days. The protein digestibility in this group was 89.2, fat - 82.5, fiber - 12.9 and Nitrogen free extractive substances (NFES) - 83.8%. The lowest digestibility indices of the nutrients were in the control group chickens, which, depending on the age, consumed feeds added with Zinc sulfate at doses corresponding to the introduction of 60, 50, and 40 g of the element per 1 ton of feed - 60.8, 80.2, 11.27, and 82.2%, respectively. Indicators of Nitrogen, Calcium, Phosphorus, and Zinc deposits in the body were also higher in the chicks of the experimental group 3 consuming the feed with Zink-mixed ligand complex. Feeding the birds with Zinc-mixed ligand complex as a component of mixed feed, in comparison with sulfate, improves the nutrients digestibility and increases the amount of chemical elements deposited in the body, which makes it possible to reduce the dose of the additive.

A series of mixed-ligand Cu(II) complexes of the type: (i) [Cu(l-pro)(diimine)(H2O)n](ClO4) (n = 0 or 1), where l-pro is l-proline and diimine is 2,2′-bipyridine (bpy; 1), (ii) 4,4′-dimethy...

The Cu2+–triglycine–L-histidine system was studied by potentiometry and calorimetry in an aqueous solution at T = 298.15 K (KNO3). Mixed-ligand CuLY and CuLHY+ complexes formed in the system. The standard thermodynamic characteristics (ΔrH°, ΔrG°, ΔrS°) of their formation reactions were determined. The possible structures of the mixed-ligand complexes were given.

Objective: In modern years, the biggest dare is to develop new chemotherapeutic agents with high efficiency as well as low toxicity. Hence, to defeat this challenge, extensive endeavors were taken on thiosemicarbazone based metal complexes. Methods: A sequence of nine thiosemicarbazone based diimine copper(II) complexes derived from three sulfur-containing ligands N-methyl-2- ((1-methyl-1H-pyrrol-2-yl)methylene)hydrazinecarbothioamide H(L1), N-ethyl-2-((1-methyl-1H-pyrrol-2-yl)methylene)hydrazinecarbothioamide H(L2), and N-benzyl-2-((1-methyl-1H-pyrrol-2-yl)methylene)hydrazinecarbothioamide H(L3). The molecular structures and coordination possibilities of thiosemicarbazone ligands toward the central metal ions have been validated by analytical and spectral techniques such as molar conductance, elemental analysis, ultraviolet–Vis, Fourier-transform infrared, and electron paramagnetic resonance spectroscopy confirms that the thiosemicarbazones ligands are coordinated to copper through NS’ donor and NN’ donor of diimine. The antimicrobial activity and DNA cleavage effectiveness of thiosemicarbazone derivatives and copper(II) complexes were assessed by disc diffusion and agarose gel electrophoresis methods. Results: All the spectral studies authenticated that the square planar geometry of the thiosemicarbazone copper(II) complexes 1–9. From the results of antibacterial activity against selected Gram-positive (Bacillus thuringiensis) and Gram-negative (Escherichia coli) bacterial strains, complex 8 exhibited noteworthy activity. Interestingly, copper(II) complexes bearing 1,10-phenanthroline (phen) moiety displayed outstanding results together with N(4)-substituted thiosemicarbazone derivatives and causes complete DNA degradation of SC (supercoiled) pUC18 DNA. Conclusion: A variety of substitutions at the thioamide nitrogen atoms have shown potential biological activity. Henceforth, N(4)-substituted thiosemicarbazone based copper(II) complexes virtually reach the effectiveness of conventional chemotherapeutic drugs.

Interaction of iridium(III) nitro-aqua complexes with 1,10-phenanthroline is studied. Complex anions [Ir(phen)(NO2)4]− and [Ir(phen)(OH)(NO2)3]− are isolated in the solid phase. The complex Na[Ir(phen)(NO2)4](phen)(H2O) is structurally characterized for the first time. Crystallographic data: $$a = 8.0752(5)\acute{\overset{\circ}{\mathrm{A}}}$$ , $$b = 11.690(7)\acute{\overset{\circ}{\mathrm{A}}}$$ , $$c = 14.012(7)\acute{\overset{\circ}{\mathrm{A}}}$$ , α = 105.55(2)°, β = 91,99(2)°, γ = 103,71(2)° space group P-1, Z = 2, ρcalc = 1,936 g/cm3. The coordination sphere of the iridium atom has a distorted octahedral geometry. The obtained structure contains an island motif consisting of the pairs of complex anions [Ir(phen)(NO2)4]− linked to each other by sodium cations.

Terpolymers with a molecular weight of 65 and 13 kDa containing 90 mol % of N-vinylpyrrolidone, 7 mol % of N-vinylformamide, and 3 mol % of N-vinyliminodiacetic acid units have been synthesized. Diethyldithiocarbamate and benzyldithiocarbamate have been used as coligands. The mixed-ligand complexation with Ga3+ ion has been studied by HPLC. The composition and structure of the resulting metal–polymer complexes have been determined by exclusion chromatography and spectral (IR, 1H NMR) data.

The formation of mixed ligand complexes in HgEdta2−–L systems (L = Asp2−, Glu2−, Ida2−, Nta3−, and Edta4−) is studied via calorimetry, pH-metry, and NMR spectroscopy. The thermodynamic parameters (log K, ΔrG°, ΔrH, ΔrS) of complexation reactions are determined at T = 298.15 K and ionic strength I = 0.5(KNO3). The most plausible mechanism of ligand coordination within a mixed-ligand complex is discussed.

The quantum chemical modeling (DFT UTPSSh/6-311++G(d,p)) of the binuclear homo- and heterometallic Fe and Co complexes based on the 5,6-bis(salicylideneimino)-1,10-phenanthroline ligand and two bipyridyl molecules is performed. The magnetic properties of these compounds can be switched due to the thermally induced spin-crossover occurring at the cobalt ions. The predicted energetic and magnetic characteristics of isomers of the studied systems allow one to consider them as promising molecular switches.

Aim: This research paper is aimed at designing a novel insulin alternative for the treatment of diabetes. Materials & methods: Six novel vanadyl(II) compounds, [(AMP−2)(VO+2)(AA n −1)]·NH4 +1, were synthesized from an equimolar ratio of adenosine monophosphate, VOSO4 and amino acids (AA n ). Results: The magnetic moments and electronic spectra revealed the square pyramidal geometrical structure of the complexes. In an in vivo study, the insulin levels, blood glucose levels, lipid profiles and histology of the pancreas and liver of the animals treated with the complexes were similar to those of healthy control animals, unlike the untreated and vanadyl sulfate(II)–treated diabetic ones. Conclusion: The data gathered in the current research illustrated that vanadyl(II)-AMP-amino acid (AA) mixed-ligand complexes can function as antidiabetic agents.

Tetracyclines are a family of drugs with interesting pleiotropic properties. The recognition by scientists of the therapeutic properties and safety profile of this class of drugs has led to the continuous derivatization of these compounds and implementation of clinical trials to explore their potential applications for a wide range of diseases. To this end, this paper review literature on tetracyclines from the discovery of the first tetracycline to a new class of tetracyclines called glycylcyclines. The DNA binding propensities of some copper (II) complex of doxycycline and mixed ligand copper (II) doxycycline complexes with polypyridyl ligands were also investigated by UV-Vis titration, viscosity and thermal melting experiments. The mixed ligand copper (II) doxycycline complexes with polypyridyl ligands were found to bind CT DNA in the major groove in a similar fashion to methyl green causing no change in the viscosity and negligible increase in thermal melting of CT DNA.

This article aimed to synthesis, spectroscopic, physicochemical characterizations, and catalytic studies on some ofloxacin (OFL) complexes with ruthenium(III) [Ru(III)] metal ions. The Ru(III)-OFL complex, [Ru(OFL)2(Cl)2]Cl and two mixed-ligand complexes, [Ru(OFL)(AA)(H2O)2]Cl2 derived from OFL as the primary ligand and amino acids [AA, either glycine (Gly) or alanine (Ala)] as the secondary ligands, were synthesized and characterized using microanalytical, spectroscopic, and physical techniques including element composition, molar conductivity, infrared, electronic spectra, thermal, X-ray powder diffraction (XRD), Energy dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), and Transmittance electron microscopy (TEM) analyses. The element analysis data describe the formation of 1:2 [Ru(III):OFL] and 1:1:1 [Ru(III):OFL:AA] complexes. The octahedral geometry of the complexes was confirmed by their magnetic moment and diffused reflectance. Fourier Transform Infrared spectroscopic (FTIR) measurements suggested that the ligands chelated with Ru(III) ions through the nitrogen atoms of the piperazine ring. In vitro antibacterial efficiency of the OFL compounds was evaluated by paper disc diffusion method. Significant antimicrobial activities were observed for some compounds of the series.

In the present work, preparation as well as photophysical characteristics of zinc(II) complexes containing pyridine-N-oxide (PNO) and 2-pyridinol-N-oxide (PHNO) along with 8-hydroxyquinoline (q) were reported. Synthesized materials [Zn(PNO)(q)] and [Zn(PHNO)(q)] revealed good thermal and electrochemical stability. Via the combination of theoretical and experimental approaches, photophysical characteristics of prepared materials were investigated. Gaussian 03 suites of programmes were used to perform all the theoretical calculations. Mixed ligand-based zinc (II) complexes were found to exhibit green emissions with wavelength of 507 and 504 nm, respectively. Temperature-dependent emission profiles of prepared metal complexes was also illustrated. Prepared materials exhibited better quantum efficiency in comparison to Alq3 and thus can be efficiently used in electroluminescent devices.