1. A new flavonol glycoside from the medicinal halophyte Suaeda fruticosa.
- Author
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Oueslati S, Ksouri R, Pichette A, Lavoie S, Girard-Lalancette K, Mshvildadze V, Abdelly C, and Legault J
- Subjects
- Antioxidants chemistry, Flavonols chemistry, Flavonols pharmacology, Fluoresceins metabolism, Glycosides chemistry, Glycosides pharmacology, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Oxidation-Reduction, Tunisia, Chenopodiaceae chemistry, Flavonols isolation & purification, Glycosides isolation & purification, Plants, Medicinal chemistry, Salt-Tolerant Plants chemistry
- Abstract
A new flavonol glycoside, namely 3-(α-rhamnopyranosyl-(1 → 2)-[β-xylopyranosyl-(1 → 6)]-β-glucopyranosyloxy) isorhamnetin was reported from methanol extracts of aerial parts of Suaeda fruticosa for the first time. In this work, liquid chromatography coupled to atmospheric pressure chemical ionisation mass spectrometry, high-resolution mass spectrometry and nuclear magnetic resonance spectroscopy were used to identify this new compound. Structure was elucidated on the basis of extensive spectroscopic analysis, including HSQC, HMBC and (1)H-(1)H COSY. Antioxidant potentialities of a pure compound were evaluated. The estimation of antioxidant capacities using oxygen radical absorbance capacity (ORAC method) and a cell based-assay (WS1) indicated that this new flavonol exhibited the highest antioxidant activities with an ORAC value of 5.0 ± 0.3 μmol Trolox/μmol and inhibited the tBH-induced oxidation of 2',7'-dichlorofluorescin with an IC50 value of 4.9 ± 0.6 μM.
- Published
- 2014
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