1. Suaedamas A-D: Four New Compounds from the Aerial Parts of Suaeda maritima with Inhibition of NO Production Activity.
- Author
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Trang BTN, Anh BTM, Mai NT, Cuc NT, Huyen LT, Nga NTH, Kiem PV, and Tai BH
- Subjects
- Animals, Mice, Dose-Response Relationship, Drug, Molecular Conformation, Molecular Structure, RAW 264.7 Cells, Structure-Activity Relationship, Dexamethasone chemistry, Dexamethasone pharmacology, Chenopodiaceae chemistry, Lipopolysaccharides antagonists & inhibitors, Lipopolysaccharides pharmacology, Nitric Oxide antagonists & inhibitors, Nitric Oxide biosynthesis, Nitric Oxide metabolism, Plant Components, Aerial chemistry, Plant Components, Aerial metabolism
- Abstract
Four new compounds, suaedamas A-D (1-4), and seven known ones (5-11) were isolated from the aerial parts of Suaeda maritima. Their chemical structures were evaluated by the IR, HR-ESI-MS, 1D-, and 2D-NMR, experimental and calculated ECD spectra. Compounds 1-6 inhibited nitric oxide production in LPS activated RAW 264.7 cells with IC
50 values ranging from 29.3 to 85.5 μM, compared to that of the positive control compound, dexamethasone, which showed IC50 value of 13.4 μM., (© 2024 Wiley-VHCA AG, Zurich, Switzerland.)- Published
- 2024
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