1. Association between periodontitis and salivary 8-hydroxydeoxyguanosine among Korean rural adults.
- Author
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Shin, Myung‐Seop, Shin, Hye‐Sun, Ahn, Yoo‐Been, and Kim, Hyun‐Duck
- Subjects
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PERIODONTITIS , *SALIVA analysis , *REACTIVE oxygen species , *ANALYSIS of covariance , *BIOMARKERS , *CHI-squared test , *PERIODONTIUM examination , *QUESTIONNAIRES , *REGRESSION analysis , *RESEARCH funding , *T-test (Statistics) , *LOGISTIC regression analysis , *OXIDATIVE stress , *CROSS-sectional method , *DATA analysis software , *DESCRIPTIVE statistics , *DEOXYRIBONUCLEOSIDES , *MANN Whitney U Test , *INTRACLASS correlation - Abstract
Objectives This study aimed to evaluate the association between salivary 8-hydroxydeoxyguanosine (8- OHdG) and periodontitis among community-dwelling Korean adults. Methods A total of 211 adults (80 men and 131 women) were cross-sectionally surveyed from the Sunchang Longevity Cohort. Periodontitis was defined as having at least 30% of teeth with proximal attachment loss ≥5 mm. The salivary 8- OHdG level was categorized into tertiles: low (<0.916 ng/ml), medium (0.916 to <2.675 ng/ml) and high (≥2.675 ng/ml). Sociodemographic, habitual and systemic health-related factors were controlled for. Logistic regression analysis was performed for the outcome of severe periodontitis. Analysis of covariance in general linear model was performed for the outcome of 8- OHdG. Results The high 8- OHdG level showed a significant association with periodontitis. The odds ratio (95% confidence interval) was 2.40 (1.05-5.51), and it was highlighted by adding the interaction term with drinking and smoking. The adjusted mean log-transformed value of 8- OHdG was significantly higher in the severe periodontitis group (1.40 ng/ml) than in the control group (1.02 ng/ml) ( ancova, P = 0.028). Conclusions 8- OHdG was associated with periodontitis. Thus, salivary 8- OHdG could be a useful marker for periodontitis. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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