4 results on '"Calvo, P. L."'
Search Results
2. Epidemiological trends of pediatric IBD in Italy: A 10-year analysis of the Italian society of pediatric gastroenterology, hepatology and nutrition registry
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Patrizia Alvisi, Flavio Labriola, Luca Scarallo, Paolo Gandullia, Daniela Knafelz, Matteo Bramuzzo, Giovanna Zuin, Maria Rosa Pastore, Maria Teresa Illiceto, Erasmo Miele, Francesco Graziano, Claudio Romano, Daniela Bartoletti, Salvatore Oliva, Serena Arrigo, Fiammetta Bracci, Sara Renzo, Anna Agrusti, Marina Aloi, Paolo Lionetti, Salvatore Accomando, Claudia Banzato, Graziano Barera, Marco Brunero, Pier Luigi Calvo, Angelo Campanozzi, Mara Cananzi, Mara Corpino, Rita Cozzali, Gianluigi De Angelis, Costantino De Giacomo, Dario Dilillo, Enrico Felici, Simona Gatti, Valentina Motta, Lorenzo Norsa, Paolo Maria Pavanello, Andrea Pession, Silvia Provera, Alberto Ravelli, Antonio Maria Ricci, Silvia Salvatore, Caterina Strisciuglio, Alvisi P., Labriola F., Scarallo L., Gandullia P., Knafelz D., Bramuzzo M., Zuin G., Pastore M.R., Illiceto M.T., Miele E., Graziano F., Romano C., Bartoletti D., Oliva S., Arrigo S., Bracci F., Renzo S., Agrusti A., Aloi M., Lionetti P., Accomando S., Banzato C., Barera G., Brunero M., Calvo P.L., Campanozzi A., Cananzi M., Corpino M., Cozzali R., De Angelis G., De Giacomo C., Dilillo D., Felici E., Gatti S., Motta V., Norsa L., Pavanello P.M., Pession A., Provera S., Ravelli A., Ricci A.M., Salvatore S., Strisciuglio C., Alvisi, P., Labriola, F., Scarallo, L., Gandullia, P., Knafelz, D., Bramuzzo, M., Zuin, G., Pastore, M. R., Illiceto, M. T., Miele, E., Graziano, F., Romano, C., Bartoletti, D., Oliva, S., Arrigo, S., Bracci, F., Renzo, S., Agrusti, A., Aloi, M., Lionetti, P., Accomando, S., Banzato, C., Barera, G., Brunero, M., Calvo, P. L., Campanozzi, A., Cananzi, M., Corpino, M., Cozzali, R., De Angelis, G., De Giacomo, C., Dilillo, D., Felici, E., Gatti, S., Motta, V., Norsa, L., Pavanello, P. M., Pession, A., Provera, S., Ravelli, A., Ricci, A. M., Salvatore, S., and Strisciuglio, C. more...
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Registrie ,Delayed Diagnosis ,Hepatology ,Delayed Diagnosi ,Gastroenterology ,Pediatric IBD ,Epidemiological trend ,Inflammatory Bowel Diseases ,Settore MED/38 - Pediatria Generale E Specialistica ,Crohn Disease ,Italy ,Epidemiological trends ,Humans ,Colitis, Ulcerative ,Registries ,Child ,Human - Abstract
Introduction: The present study aimed at evaluating Italian epidemiological trends of pediatric inflammatory bowel diseases (IBD) over the period 2009–2018. Materials and methods: Data from 1969 patients enrolled in the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition Registry, by 49 pediatric IBD centers throughout the country, were analyzed, comparing three different time intervals (2009–2012, 2013–2015, 2016–2018). Results: The number of new IBD diagnoses ranged from 175 to 219 per year, evenly distributed over the examined period of time. From 2009 to 2018, the minimal incidence ranged from 1.59 to 2.04 /105 inhabitants aged < 18 years, with an overall slight predominance of ulcerative colitis (UC) over Crohn's disease (CD) (ratio: 1.1). Mean diagnostic delay was 6.8 months for CD and 4.1 months for UC, with a significant reduction for CD when comparing the three-time intervals (p =0.008). The most frequent disease locations according to the Paris classification were ileocolonic for CD (41.3%) and pancolitis for UC (54.6%). Conclusions: The minimal incidence rate in Italy seems to have stabilized over the last two decades, even if it has increased when compared to previous reports. UC is still slightly more prevalent than CD in our country. Diagnostic delay significantly decreased for CD, reflecting an improved diagnostic capacity. more...
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- 2022
Catalog
3. Etiology, presenting features and outcome of children with non-cirrhotic portal vein thrombosis: A multicentre national study
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Pier Luigi Calvo, Silvia Riva, Giuseppe Maggiore, Raffaele Iorio, Paola De Angelis, Maurizio Cheli, Lorenzo D'Antiga, Giuseppe Indolfi, Pietro Vajro, Emanuele Nicastro, Angelo Di Giorgio, Mara Cananzi, Di Giorgio, A., De Angelis, P., Cheli, M., Vajro, P., Iorio, R., Cananzi, M., Riva, S., Maggiore, G., Indolfi, G., Calvo, P. L., Nicastro, E., and D'Antiga, L. more...
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Male ,Diseases ,Infant, Newborn, Diseases ,0302 clinical medicine ,Child ,Children ,Venous Thrombosis ,medicine.diagnostic_test ,Portal Vein ,Gastroenterology ,Portal vein thrombosis ,Venous thrombosis ,Italy ,030220 oncology & carcinogenesis ,Child, Preschool ,Hypertension ,Portal hypertension ,030211 gastroenterology & hepatology ,Female ,Gastrointestinal Hemorrhage ,Infant, Premature ,medicine.medical_specialty ,Gastrointestinal bleeding ,Adolescent ,Socio-culturale ,Esophageal and Gastric Varices ,Hypersplenism ,Catheterization ,03 medical and health sciences ,Hypertension, Portal ,medicine ,Humans ,Transjugular Intrahepatic ,Portasystemic Shunt ,Extra-hepatic portal vein obstruction ,Non-cirrhotic portal hypertension ,Infant ,Infant, Newborn ,Portasystemic Shunt, Transjugular Intrahepatic ,Splenomegaly ,Preschool ,Survival rate ,Premature ,Children, Extra-hepatic portal vein obstruction, Non-cirrhotic portal hypertension, Portal vein thrombosis ,Hepatology ,business.industry ,medicine.disease ,Newborn ,Surgery ,Endoscopy ,Etiology ,Portal ,business ,Varices - Abstract
Objectives Non-cirrhotic portal vein thrombosis (PVT) is a main cause of portal hypertension in children. We describe the characteristics at presentation and outcome of a cohort of patients with PVT to determine clinical features and predictors of outcome. Methods We recorded: (1) Associated factors: prematurity, congenital malformations, neonatal illnesses, umbilical vein catheterization (UVC), deep infections, surgery; (2) congenital and acquired prothrombotic disorders; (3) features at last follow up including survival rate and need for surgery. Results 187 patients, mean age at diagnosis 4 ± 3.7 years, had a history of prematurity (61%); UVC (65%); neonatal illnesses (79%). The diagnosis followed the detection of splenomegaly (40%), gastrointestinal bleeding (36%), hypersplenism (6%), or was incidental (18%). Of 71 patients who had endoscopy at presentation 62 (87%) had oesophageal varices. After 11.3 years’ follow up 63 (34%) required surgery or TIPS. Ten-year survival rate was 98%, with 90% shunt patency. Spleen size, variceal bleeding and hypersplenism at presentation were predictors of surgery or TIPS (p Conclusion PVT is associated with congenital and acquired co-morbidities. History of prematurity, neonatal illnesses and UVC should lead to rule out PVT. Large spleen, variceal bleeding and hypersplenism at presentation predict the need for eventual surgery in a third of cases. more...
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- 2019
4. Treatment and monitoring of children with chronic hepatitis C in the Pre-DAA era: A European survey of 38 paediatric specialists
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Indolfi, Giuseppe, Bailey, Heather, Serranti, Daniele, Giaquinto, Carlo, Thorne, Claire, Jahnel, Jörg, Sokal, Etienne, Lamireau, Thierry, Lacaille, Florence, Debray, Dominique, Girard, Muriel, Feiterna‐Sperling, Cornelia, Wirth, Stefan, Vassiliki, Papaevangelou, Dezsofi, Antal, Guidi, Roberto, Verucchi, Gabriella, D'Antiga, Lorenzo, Nicastro, Emanuele, Maggiore, Giuseppe, Trapani, Sandra, Ricci, Silvia, Resti, Massimo, Giacomet, Vania, Benincaso, Anna Rita, Nebbia, Gabriella, Iorio, Raffaele, Cananzi, Mara, Riva, Silvia, Bossi, Grazia, Dodi, Icilio, Nobili, Valerio, Comparcola, Donatella, Garazzino, Silvia, Calvo, Pier Luigi, Pokorska‐Śpiewak, Maria, Pawlowska, Malgorzata, Gonçalves, Cristina, Gonçalves, Isabel, Tudor, Ana Maria, Julian, Antoni Noguera, Hierro, Loreto, Ramos, Jose T., Fischler, Björn, McLin, Valérie, Kansu, Turkey Aydan, Brown, Maxine, Kelly, Deirdre, Davison, Suzanne, Turkova, Anna, Bamford, Alasdair, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, Indolfi, G., Bailey, H., Serranti, D., Giaquinto, C., Thorne, C., Sokal, E., Debray, D., Girard, M., Feiterna-Sperling, C., Wirth, S., Guidi, R., Verucchi, G., D'Antiga, L., Nicastro, E., Maggiore, G., Trapani, S., Ricci, S., Resti, M., Giacomet, V., Benincaso, A. R., Nebbia, G., Iorio, R., Cananzi, M., Riva, S., Bossi, G., Dodi, I., Nobili, V., Comparcola, D., Garazzino, S., Calvo, P. L., Pokorska-Spiewak, M., Pawlowska, M., Goncalves, C., Goncalves, I., Bals, M., Tudor, A. M., Noguera-Julian, A., Ramos, J. T., Fischler, B., Mclin, V., Brown, M., Kelly, D., Davison, S., Turkova, A., Bamford, A., Indolfi G., Bailey H., Serranti D., Giaquinto C., Thorne C., Sokal E., Debray D., Girard M., Feiterna-Sperling C., Wirth S., Guidi R., Verucchi G., D'Antiga L., Nicastro E., Maggiore G., Trapani S., Ricci S., Resti M., Giacomet V., Benincaso A.R., Nebbia G., Iorio R., Cananzi M., Riva S., Bossi G., Dodi I., Nobili V., Comparcola D., Garazzino S., Calvo P.L., Pokorska-Spiewak M., Pawlowska M., Goncalves C., Goncalves I., Bals M., Tudor A.M., Noguera-Julian A., Ramos J.T., Fischler B., McLin V., Brown M., Kelly D., Davison S., Turkova A., and Bamford A. more...
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Male ,Pediatrics ,Cirrhosis ,Epidemiology ,medicine.medical_treatment ,Hepacivirus ,Liver transplantation ,medicine.disease_cause ,Direct-acting antivirals ,Liver disease ,0302 clinical medicine ,030212 general & internal medicine ,Europe, direct-acting antivirals, epidemiology, treatment, vertical transmission ,Child ,education.field_of_study ,treatment ,Age Factors ,Europe ,Infectious Diseases ,Child, Preschool ,Vertical transmission ,Female ,030211 gastroenterology & hepatology ,epidemiology ,medicine.medical_specialty ,Adolescent ,Genotype ,Attitude of Health Personnel ,Hepatitis C virus ,Population ,Socio-culturale ,Antiviral Agents ,03 medical and health sciences ,Chronic hepatitis ,Hcv genotype 1 ,Virology ,medicine ,Humans ,Pediatricians ,education ,direct-acting antivirals ,direct-acting antiviral ,Hepatology ,business.industry ,Infant, Newborn ,Infant ,Hepatitis C, Chronic ,medicine.disease ,Treatment ,Cross-Sectional Studies ,Health Care Surveys ,vertical transmission ,business - Abstract
The burden of paediatric HCV infection across Europe is unknown, as are current policies regarding monitoring and treatment. This collaborative study aimed to collect aggregate data to characterise the population of ≤18-year olds with HCV infection in specialist follow up in a twelve-month period (2016) across the PENTAHep European consortium, and investigate current policies around monitoring and treatment. A cross-sectional, web-based survey was distributed in April 2017 to 50 paediatricians in 19 European countries, covering patients' profile, and monitoring and treatment practices. Responses were received from 38/50 clinicians collectively caring for 663 children with chronic HCV infection of whom three-quarters were aged ≥6 years and 90% vertically-infected. HCV genotype 1 was the most common (n 380; 57.3%), followed by genotype 3, 4 and 2. Seventeen children (3%) with chronic HCV infection were diagnosed with cirrhosis and 6 were reported to have received liver transplantation for HCV-related liver disease. The majority (n 425; 64.1%) of the European children with HCV infection remained treatment-naive in 2016. Age affected clinicians' attitudes towards treatment; 94% reported being willing to use direct-acting antivirals, if available, in adolescents (aged ≥11 years), 78% in children aged 6-10 and 42% in those 3 to 5 years of age (Pearson correlation coefficient -0.98; p 0.0001). This survey provides the largest characterisation of the population of children in clinical follow-up for chronic HCV infection in Europe, alongside important contextual information on their management and treatment. Discussion is needed around strategies and criteria for use of direct-acting antivirals in these children. This article is protected by copyright. All rights reserved more...
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- 2019
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