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1. Methotrexate as a possible trigger of macrophage activation syndrome in systemic juvenile idiopathic arthritis

Author

A, Ravelli, M C, Caria, S, Buratti, C, Malattia, F, Temporini, and A, Martini

Subjects
Methotrexate, Antirheumatic Agents, Macrophages, Humans, Female, Syndrome, Macrophage Activation, Child, Arthritis, Juvenile
Abstract

Macrophage activation syndrome (MAS) is a potentially life threatening complication of chronic rheumatic diseases, particularly systemic juvenile idiopathic arthritis (JIA). A number of triggers have been related to the development of MAS, including viral infections, nonsteroidal antiinflammatory drug therapy, and gold salt injections. We describe a patient with systemic JIA who developed MAS shortly after receiving methotrexate, suggesting that this drug can be regarded as a potential trigger of MAS in children with JIA.

Published
2001

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