Search

Your search keyword '"Nabawanuka E"' showing total 2 results
Start Over Author "Nabawanuka E" Topic child
2 results on '"Nabawanuka E"'

1. A predictive algorithm for identifying children with sickle cell anemia among children admitted to hospital with severe anemia in Africa

Author

Olupot-Olupot, P, Connon, R, Kiguli, S, Opoka, RO, Alaroker, F, Uyoga, S, Nakuya, M, Okiror, W, Nteziyaremye, J, Ssenyondo, T, Nabawanuka, E, Kayaga, J, Williams Mukisa, C, Amorut, D, Muhindo, R, Frost, G, Walsh, K, Macharia, AW, Gibb, DM, Walker, AS, George, EC, Maitland, K, Williams, TN, Williams, T, Wellcome Trust, Medical Research Council, and Medical Research Council (MRC)

Subjects
OUTCOMES, Malawi, Science & Technology, Immunology, hemic and immune systems, Hematology, Anemia, Sickle Cell, DISEASE, Hospitals, MALARIA, Humans, Uganda, BURDEN, Child, Life Sciences & Biomedicine, 1102 Cardiorespiratory Medicine and Haematology, reproductive and urinary physiology, Algorithms
Abstract

Sickle cell anemia (SCA) is common in sub-Saharan Africa where approximately 1% of births are affected. Severe anemia is a common cause for hospital admission within the region yet few studies have investigated the contribution made by SCA. The Transfusion and Treatment of severe anemia in African Children Trial (ISRCTN84086586) investigated various treatment strategies in 3983 children admitted with severe anemia (hemoglobin

Published
2022
Full Text
View/download PDF

2. Cotrimoxazole or multi-mineral multi-vitamins to improve post-discharge outcomes following severe anaemia in African children: a randomised controlled trial

Author

Maitland, K, Olupot-Olupot, P, Kiguli, S, Chagaluka, G, Alaroker, F, Opoka, R, Mpoya, A, Walsh, K, Engoru, C, Nteziyaremye, J, Mallewa, M, Kennedy, N, Nakuya, M, Namayanja, C, Kayaga, J, Nabawanuka, E, Sennyondo, T, Aromut, D, Kumwenda, F, Williams Musika, C, Thomason, M, Bates, I, Boele Von Hensbroek, M, Evans, J, Uyoya, S, Williams, T, Frost, G, George, E, Gibb, D, Walker, A, Medical Research Council (MRC), Medical Research Council, Medical Research Council, UK, Imperial College Healthcare NHS Trust- BRC Funding, and Engineering & Physical Science Research Council (EPSRC)

Subjects
SPRINKLES, YOUNG-CHILDREN, Malawi, Science & Technology, IRON FORTIFICATION, MORTALITY, Infant, Anemia, PROPHYLAXIS, Patient Discharge, TRACT trial group, 1117 Public Health and Health Services, DEFICIENCY, DOUBLE-BLIND, MALARIA, TRANSFUSION, INFECTION, Dietary Supplements, Trimethoprim, Sulfamethoxazole Drug Combination, Humans, Uganda, Child, Life Sciences & Biomedicine, Public, Environmental & Occupational Health, 0605 Microbiology
Abstract

Background: Severe anaemia (haemoglobin0.2). By day180, 489(24%) MVMM vs 509(26%) iron/folate had experienced one or more SAEs (HR=0.95 (0.84- 1.07), p=0.40) and 500(25%) cotrimoxazole vs 498(25%) no cotrimoxazole (HR=1.01 (0.89,1.15) p=0.85). Most SAEs were readmissions, occurring in 692(17%) children (175(4%) with ≥2 readmissions). Interpretation: Neither enhanced supplementation with MVMM versus iron/folate treatment or cotrimoxazole prophylaxis improved 6-month survival. High rates of hospital re-admission suggest that novel interventions are urgently required for severe anaemia, given the burden it places on overstretched health services in Africa.

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results