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2 results on '"Paula Hale"'

1. Factors to Consider in Development of Drugs for Pediatric Nonalcoholic Fatty Liver Disease

Author

Miriam B. Vos, Lara Dimick-Santos, Ruby Mehta, Stephanie O. Omokaro, Johannes Taminiau, Elmer Schabel, David E. Kleiner, Peter Szitanyi, Piotr Socha, Jeffrey B. Schwimmer, Stephanie Noviello, Debra G. Silberg, Richard Torstenson, Veronica Miller, Joel E. Lavine, Nathalie Adda, William Baldyga, Rajarshi Banerjee, Cynthia Behling, Sherif Boulos, Gary Burgess, Dania Calboli, Edgar Charles, Rose Christian, Claude Cohen-Bacrie, Doina Cosma-Roman, Claus-Peter Danzer, Ingrid Delaet, Mark Delegge, Nicholas DiProspero, Kathleen Donohue, Laurent Fischer, Emer Fitzpatrick, Michael Fried, David Hagerty, Paula Hale, Keri Hildick, Dean Hum, Khurram Jamil, Lijuan Jiang, Saul Karpen, Matt Kelly, Rohit Kohli, Kattayoun Kordy, Nancy Krieger, Joel Lavine, Lois Lee, Eric Lefebvre, Patricia Lopez, Erica Lyons, Laura Malahias, Sophie Megnien, Peter Mesenbrink, Pansy Minnick, Christine Murray, Tien Nghiem, Nikki Nicholson, Wenjie Pang, Lisa Percival, Dan Peres, Margaret Powell, Dragos Roman, Mark Root, Claire Sampson, Arun Sanyal, Kathleen Schwarz, Star Seyedkazemi, David Shapiro, Reshma Shringarpure, Debra Silberg, Edward Smith, Robert Squires, William Treem, Pamela Vig, Miriam Vos, Mason Yamashita, Michael Zemel, and Liver Forum Pediat Working Grp

Subjects
medicine.medical_specialty, MEDLINE, Gastroenterology, Severity of Illness Index, Article, Drug Development, Non-alcoholic Fatty Liver Disease, Internal medicine, Nonalcoholic fatty liver disease, Severity of illness, medicine, Prevalence, Humans, Child, Clinical Trials as Topic, Hepatology, business.industry, Patient Selection, Age Factors, medicine.disease, Drug development, Liver, Human medicine, business, Liver pathology
Published
2019

2. Enhanced chromatid damage in blood lymphocytes after G2 phase x irradiation, a marker of the ataxia-telangiectasia gene

Author

Gary M. Jones, Robert E. Tarone, Thomas A. Waldmann, Paula Hale, Katherine K. Sanford, Floyd M. Price, Lindsay Eierman, and Ram Parshad

Subjects
Adult, Male, Cancer Research, Heterozygote, Adolescent, DNA repair, DNA damage, Lymphocyte, Biology, Chromatids, Radiation Tolerance, chemistry.chemical_compound, Ataxia Telangiectasia, medicine, Humans, Radiosensitivity, Lymphocytes, Child, Interphase, Aged, Middle Aged, medicine.disease, Molecular biology, medicine.anatomical_structure, Oncology, chemistry, Demecolcine, Immunology, Ataxia-telangiectasia, Chromatid, Female, Radiation Induced DNA Damage, DNA Damage
Abstract

An assay for ataxia-telangiectasia (A-T) heterozygotes, i.e., healthy carriers of the A-T gene(s), requiring only a small sample (3.5 mL) of peripheral blood, is described. Frequencies of chromatid aberrations in phytohemagglutinin-stimulated blood lymphocytes collected by demecolcine from 0.5 hour to 1.5 hours after x irradiation with 58 roentgens were twofold to threefold higher in A-T heterozygotes than in clinically normal controls and twofold to three-fold higher in A-T patients (homozygotes) than in A-T gene carriers. The persistence of chromatid breaks and gaps in lymphocytes following radiation-induced DNA damage during G2 suggests a deficiency or deficiencies in DNA repair that may be the defect at the molecular level that results in the enhanced radiosensitivity and cancer proneness characterizing A-T gene carriers and patients.

Published
1990

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