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1. The Comparison of Growth and Developmental Status in Surgical Necrotizing Enterocolitis with the Control Group.

Author

Jamshidi, Masoud, Mirnia, Kayvan, Emamjamaat, Maryam, Heidarabady, Seifollah, and Rafeey, Mandana

Subjects
NEONATAL necrotizing enterocolitis, HUMAN growth, INFANT development, CROSS-sectional method, POSTOPERATIVE period, QUESTIONNAIRES, CHI-squared test, DESCRIPTIVE statistics, DATA analysis software
Abstract

Background: Surgery in premature neonates following Necrotizing Enterocolitis (NEC) is an awful event. There are many concerns regarding the future of these neonates. Releasing inflammatory substances following perforation can have a significant impact on the premature brain. Based on the ASQ questionnaire, we aimed at finding out whether there is any neurodevelopmental delay following NEC surgery. Methods: We compared developmental aspects of neonates who underwent NEC surgery with control using the Ages and Stages Questionnaire (ASQ II). Results: We compared 29 children that had surgical NEC in their neonatal period with their premature peers. They were homogeneous in age, sex, head circumference, weight, and Apgar count at birth in the neonatal period; they had no significant difference in the incidence of sepsis and ventilation-requiring days and cerebral incidence hemorrhage. At the study time, there was a significant difference in growth parameters, weight (p<0.001), and height (p=0.014). Also, there was no significant difference in head circumference and developmental parameters such as communication, motor, and problem-solving domains. Conclusion: This study indicates that if these patients do not develop severe neurological complications in the neonatal period, their abilities are close to their premature peers in arrival to community and school. However, we still recommend close monitoring of these cases due to the possibility of impaired central nervous-gastrointestinal coordination. [ABSTRACT FROM AUTHOR]

Published
2022
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3. Sinonasal Manifestations in Children with Cystic Fibrosis.

Author

Rafeey, Mandana, Moghaddam, Yalda Jabbari, and Rezaeeyan, Saman

Subjects
*CYSTIC fibrosis diagnosis, *SINUSITIS, *COMPUTED tomography, *CYSTIC fibrosis, *ENDOSCOPY, *NASAL cavity, *NOSE, *PARANASAL sinuses, *POLYPS, *QUESTIONNAIRES, *SYMPTOMS, *DIAGNOSIS
Abstract

Background: Involvement of the upper respiratory tract and pathological changes in the nose and paranasal sinuses are common in patients with cystic fibrosis. Objectives: We aimed to identify sinonasal manifestations in Iranian children with cystic fibrosis. Methods: Forthy seven children with cystic fibrosis were enrolled and symptoms related to the nose and paranasal sinuses were recorded using a questionnaire. The patients' nasal and sinus CT scan were investigated in terms of findings related to cystic fibrosis. Results: The most common complaint was nasal congestion (61.7%). Ground glass opacity in the nasal cavity was found in 63.8% of the patients. Postnasal drip was observed in 362% of the patients. In nasal endoscopic examination, 15 (31.9%) patients had clear polyps in the nasal cavity. Conclusions: History, CT scans, and initial clinical examination (rhinorrhea in anterior rhinoscopy) does not allow accurate diagnosis of chronic rhino sinusitis or nasal polyps in children with cystic fibrosis. [ABSTRACT FROM AUTHOR]

Published
2019
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5. Intercontinental comparison of caustic ingestion in children.

Author

Rafeey, Mandana, Ghojazadeh, Morteza, Mehdizadeh, Amir, Hazrati, Hakimeh, and Vahedi, Leila

Subjects
*INGESTION disorders in children, *PEDIATRIC therapy
Abstract

Purpose: To investigate the caustic ingestion in children among different continents according to demographic characteristics (core purpose), main symptoms, common caustic agents, signs and symptoms, management, treatment and complications. Methods: This systematic review was performed by searching the databases Science Direct, ProQuest, Google Scholar, and PubMed, electronically and manually. We included studies that were published from 1980 to 2013, at University of Medical Sciences of Tabriz, Iran. A strategic search was performed with keywords including caustic, corrosive, ingestion and children, and was limited to articles in English and Persian. Statistical analysis was performed by SPSS ver. 18. Results: Of 63 selected articles of caustic ingestion with 9,888 samples, the proportion of Africa was 3 articles (4.8%) and 95 samples (1%), America 9 articles (14.3%) and 305 sample (3%), Asia 29 articles (46%) and 2,780 samples (28.1%), Europe 17 articles (27%) and 3,002 samples (30.4%), and Oceania 5 articles (7.9%) and 3,706 samples (37.5%). The average age was in the Africa 3.07±2.02 years, America 3.17±1.83 years, Asia 3.34±1.58 years, Europe 3.58±2.09 years and Oceania 3.52±2.02 years. Sex distribution was in Africa 76 males (0.91%) and 19 females (0.23%), America 49 males (0.58%) and 41 females (0.49%), Asia 1,575 males (18.76%) and 1,087 females (12.95%), Europe 1,018 males (12.13%) and 823 females (9.8%), and Oceania 1,918 males (22.85%) and 1,788 females (21.3%). Statistical analysis of the data indicated higher consumption in Europe and Oceania in the boys with higher average age of years. Conclusion: The comparison of caustic ingestion indicated that the cause substances of caustic ingestion in children are different among continents, therefore prevention strategy and different treatment guidelines among continents will be needed. [ABSTRACT FROM AUTHOR]

Published
2015
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6. The Pediatric Otolaryngology Manifestations of Gastroesophageal Reflux Disease.

Author

moghaddam, Yalda Jabbari and Rafeey, Mandana

Subjects
GASTROESOPHAGEAL reflux diagnosis, GASTROESOPHAGEAL reflux treatment, DIFFERENTIAL diagnosis, OTOLARYNGOLOGY, PEDIATRICS
Abstract

Backgrounds and Objectives: The Gastroesophageal Reflux Disease (GERD) introduced as a major predisposing factor of laryngeal and extra laryngeal disorders .This study designed to evaluate the correlation between the GERD and otolaryngology problems. Material and Methods: This descriptive cross -sectional study contained 40 pediatrics with GERD diagnosis. GERD was diagnosed based on the symptoms, radiological, endoscopic findings, and specific GERD questioner (GERDQ). First, all of otolaryngology complications evaluated and the findings were recorded by questionnaire, then medical treatments were started and after one and six months of follow up all of clinical finding were recorded. Results: The family history was negative in 85% of cases. Cough was the most common complain (57.5%). One month after treatment ten percent of gastrointestinal and 35% of ENT symptoms recovered. 6 months after the treatment 64/86% of both gastrointestinal and ENT symptoms were fully recovered. Conclusions: Our study revealed that Gastroesophageal Reflux disease should be suspected and treated in all children with prolonged and unresponsive otolaryngologic disease. [ABSTRACT FROM AUTHOR]

Published
2014

7. Comparative assessment of Helicobacter pylori colonization in children tonsillar tissues

Author

Jabbari Moghaddam, Yalda, Rafeey, Mandana, and Radfar, Reza

Subjects
*COMPARATIVE studies, *HELICOBACTER pylori, *HEALTH surveys, *UREASE, *MEDICAL screening, *TONSIL diseases, *JUVENILE diseases, *LONGITUDINAL method
Abstract

Abstract: Objective: The objective was to survey the results of RUT (rapid urease test) in children tonsillar tissues. Methods: In a prospective clinical study 285 children (4–14 years) tonsillar tissue tested with RUT (rapid urease test) and histopathologic biopsy and simultaneously serum IgG Helicobacter pylori level was measured for all patients. Results: One hundred and thirteen patients (39.6%) were positive to H. pylori in histopathologic examination. Forty patients (14%) had positive RUT and 15 patients had positive serum IgG anti-H. pylori level. In 40 patients the results in both histopathology and RUT were positive (P =0.000) although in 172 patients the results in both histopatologhic and RUT were negative (P =0.000). Conclusions: This study showed that H. pylori was present in tonsillar tissue and RUT is not sensitive enough for diagnosis of H. pylori in tonsillar tissue. Indicating that H. pylori has a possible role in reservoir of H. pylori in children. [Copyright &y& Elsevier]

Published
2009
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8. Accuracy in Diagnosis of Celiac Disease Without Biopsies in Clinical Practice

Author

Sven Seiwerth, Annette M. Müller, Manfred Ratschek, Bożena Cukrowska, Gemma Castillejo, Vanesa Morente, Jorge Amil Dias, Sara Morgenstern, Marco Gasparetto, Nailah Brown, Alexandra Papadopoulou, Gabriele Amann, Kalle Kurppa, Vincenzo Villanacci, Almuthe C. Hauer, Francesc Martínez, Miguel Bolonio, Anikó Nagy, Tine Plato Hansen, Yvan Vandenplas, Sonja Thanner-Lechner, Kaija Laurila, Rita Kőbányai, Søren Thue Lillevang, Zrinjka Mišak, Riccardo Troncone, Pavel Frűhauf, Adina Ene, Jernej Dolinsek, Konstantina Dimakou, Fabio Massimo Magliocca, Annieta Goossens, Vered Nachmias Friedler, Maryam Monajemzadeh, Amir Taher Eftekhar Sadat, Mandana Rafeey, Jan Wyhowski, Rafaella Nenna, Françoise Smets, Hélène Garnier-Lengliné, Marianna Salemme, Martine Vornane, Stine Dydensborg Sander, Hany Banoub, Anne Mourin, Mariantonia Maglio, Stephanie Van Biervliet, Birgit Filipiak, M. L. Mearin, Mehri Najafi, Gauri Batra, Judit Gyimesi, Hubert Kogler, Gabriele Heilig, Raanan Shamir, Laura Petrarca, Katayoun Khatami, Myriam Van Winckel, Susana Corujeira, Hania Szajewska, Ilma Rita Korponay-Szabó, Alina Popp, Stefan Buderus, Sonny K. F. Chong, Elke Janssens, Francesca Penagini, Vincent T.H.B.M. Smit, Judit B. Kovács, Rajko Kavalar, Thomas Kirchner, Carmen Ribes-Koninckx, Renata Auricchio, Ruth Achten, Ester Donat, Catherine Wanty, Nicolas Kalach, Danielle Canioni, Philippe Alliet, Ilona Lellei, Sibylle Koletzko, Yulia Dmitrieva, Fátima Carneiro, Liz Hook, David Fernández Ramos, Roberta Kosova, Dmitry Abramov, Markku Mäki, Helena Skalova, Adrian G. Thomas, Steffen Husby, Steve Sampson, Katharina Julia Werkstetter, Piotr Socha, Andreas Vécsei, Amalia Patereli, Peter Szitanyi, Saskia Vande Velde, Maaike W. Schaart, Pierre Gosset, Growth and Development, Clinical sciences, Werkstetter, K. J, Korponay Szabó, I. R, Popp, A, Villanacci, V, Salemme, M, Heilig, G, Lillevang, S. T, Mearin, M. L, Ribes Koninckx, C, Thomas, A, Troncone, Riccardo, Filipiak, B, Mäki, M, Gyimesi, J, Najafi, M, Dolinšek, J, Dydensborg Sander, S, Auricchio, Renata, Papadopoulou, A, Vécsei, A, Szitanyi, P, Donat, E, Nenna, R, Alliet, Ph, Penagini, F, Garnier Lengliné, H, Castillejo, G, Kurppa, K, Shamir, R, Hauer, A. C, Smets, F, Corujeira, S, van Winckel, M, Buderus, S, Chong, S, Husby, S, Koletzko, S, Socha, Piotr, Bozena Cukrowska, Null, Szajewska, Hania, Wyhowski, Jan, Brown, Nailah, Batra, Gauri, Misak, Zrinjka, Seiwerth, Sven, Dmitrieva, Yulia, Abramov, Dmitry, Vandenplas, Yvan, Goossens, Annieta, Schaart, Maaike W, Smit, V. T. H. B. M, Kalach, Nicola, Gosset, Pierre, Kovács, Judit B, Nagy, Anikó, Lellei, Ilona, Kőbányai, Rita, Khatami, Katayoun, Monajemzadeh, Maryam, Dimakou, Konstantina, Patereli, Amalia, Plato Hansen, Tine, Kavalar, Rajko, Bolonio, Miguel, Kogler, Hubert, Amann, Gabriele, Kosova, Roberta, Maglio, Mariantonia, Janssens, Elke, Achten, Ruth, Frűhauf, Pavel, Skálová, Helena, Kirchner, Thoma, Petrarca, Laura, Magliocca, Fabio Massimo, Martínez, Francesc, Morente, Vanesa, Thanner Lechner, Sonja, Ratschek, Manfred, Gasparetto, Marco, Hook, Liz, Canioni, Danielle, Wanty, Catherine, Mourin, Anne, Laurila, Kaija, Vornane, Martine, Nachmias Friedler, Vered, Morgenstern, Sara L, Amil Dias, Jorge, Carneiro, Fátima, Van Biervliet, Stephanie, Vande Velde, Saskia, Banoub, Hany, Sampson, Steve, Müller, Annette M, Ene, Adina, Rafeey, Mandana, and Eftekhar Sadat, Iran Amir Taher

Subjects
Male, Autoimmunity, ESPGHAN, nonbiopsy approach, ProCeDE study, adolescent, autoantibodies, biomarkers, biopsy, celiac disease, child, child preschool, Europe, female, GTP-binding proteins, HLA-DQ antigens, humans, immunoglobulin A, infant, intestine small, male, Middle East, molecular diagnostic techniques, predictive value of tests, prognosis, prospective studies, reproducibility of results, serologic tests, transglutaminases, Biopsy, gastroenterology, non-biopsy approach, HLA-DQ Antigens/genetics, 0302 clinical medicine, Immunoglobulin A/blood, Intestine, Small, Nonbiopsy Approach, Prospective Studies, Prospective cohort study, Child, education.field_of_study, medicine.diagnostic_test, Orvostudományok, Prognosis, Multicenter Study, medicine.anatomical_structure, Molecular Diagnostic Techniques, Transglutaminases/immunology, Predictive value of tests, Child, Preschool, 030211 gastroenterology & hepatology, Female, Intestine, Small/immunology, medicine.medical_specialty, Child, preschool, Adolescent, Anemia, Population, Celiac Disease/blood, Klinikai orvostudományok, 03 medical and health sciences, autoimmunity, proCeDE study, GTP-Binding Proteins, Predictive Value of Tests, 030225 pediatrics, Internal medicine, HLA-DQ Antigens, medicine, Journal Article, Humans, Protein Glutamine gamma Glutamyltransferase 2, Serologic Tests, Validation Studies, education, Pediatric gastroenterology, GTP-Binding Proteins/immunology, ProCeDE Study, Transglutaminases, business.industry, Infant, Reproducibility of Results, Hepatology, Endomysium, medicine.disease, Surgery, Immunoglobulin A, Celiac Disease, hepatology, business, Autoantibodies/blood, Biomarkers/blood
Abstract

Background & Aims The guidelines of the European Society of Pediatric Gastroenterology, Hepatology, and Nutrition allow for diagnosis of celiac disease without biopsies in children with symptoms and levels of immunoglobulin A against tissue-transglutaminase (TGA-IgA) 10-fold or more the upper limit of normal (ULN), confirmed by detection of endomysium antibodies (EMA) and positivity for HLA-DQ2/DQ8. We performed a large, international prospective study to validate this approach. Methods We collected data from consecutive pediatric patients (18 years or younger) on a gluten-containing diet who tested positive for TGA-IgA from November 2011 through May 2014, seen at 33 pediatric gastroenterology units in 21 countries. Local centers recorded symptoms; measurements of total IgA, TGA, and EMA; and histopathology findings from duodenal biopsies. Children were considered to have malabsorption if they had chronic diarrhea, weight loss (or insufficient gain), growth failure, or anemia. We directly compared central findings from 16 antibody tests (8 for TGA-IgA, 1 for TGA-IgG, 6 for IgG against deamidated gliadin peptides, and 1 for EMA, from 5 different manufacturers), 2 HLA-DQ2/DQ8 tests from 2 manufacturers, and histopathology findings from the reference pathologist. Final diagnoses were based on local and central results. If all local and central results were concordant for celiac disease, cases were classified as proven celiac disease. Patients with only a low level of TGA-IgA (threefold or less the ULN) but no other results indicating celiac disease were classified as no celiac disease. Central histo-morphometry analyses were performed on all other biopsies and cases were carefully reviewed in a blinded manner. Inconclusive cases were regarded as not having celiac disease for calculation of diagnostic accuracy. The primary aim was to determine whether the nonbiopsy approach identifies children with celiac disease with a positive predictive value (PPV) above 99% in clinical practice. Secondary aims included comparing performance of different serological tests and to determine whether the suggested criteria can be simplified. Results Of 803 children recruited for the study, 96 were excluded due to incomplete data, low level of IgA, or poor-quality biopsies. In the remaining 707 children (65.1% girls; median age, 6.2 years), 645 were diagnosed with celiac disease, 46 were found not to have celiac disease, and 16 had inconclusive results. Findings from local laboratories of TGA-IgA 10-fold or more the ULN, a positive result from the test for EMA, and any symptom identified children with celiac disease (n = 399) with a PPV of 99.75 (95% confidence interval [CI], 98.61–99.99); the PPV was 100.00 (95% CI, 98.68–100.00) when only malabsorption symptoms were used instead of any symptom (n = 278). Inclusion of HLA analyses did not increase accuracy. Findings from central laboratories differed greatly for patients with lower levels of antibodies, but when levels of TGA-IgA were 10-fold or more the ULN, PPVs ranged from 99.63 (95% CI, 98.67–99.96) to 100.00 (95% CI, 99.23–100.00). Conclusions Children can be accurately diagnosed with celiac disease without biopsy analysis. Diagnosis based on level of TGA-IgA 10-fold or more the ULN, a positive result from the EMA tests in a second blood sample, and the presence of at least 1 symptom could avoid risks and costs of endoscopy for more than half the children with celiac disease worldwide. HLA analysis is not required for accurate diagnosis. Clinical Trial Registration no: DRKS00003555.

Published
2017

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