1. <italic>CRLF2</italic> and <italic>IKZF1</italic> abnormalities in childhood hematological malignancies other than B-cell Acute Lymphoblastic Leukemia.
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Moreno-Lorenzana, Dafné, Juárez-Velázquez, Rocío, Reyes-León, Adriana, Martínez-Anaya, Daniel, Juárez-Villegas, Luis, Zapata Tarrés, Martha, López Santiago, Norma, and Pérez-Vera, Patricia
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HEMATOLOGIC malignancies , *LYMPHOBLASTIC leukemia , *ACUTE leukemia , *BIOMARKERS , *CHILD patients - Abstract
AbstractRearrangements and overexpression of
CRLF2 are hallmarks of poor outcomes inBCR::ABL1 -like B-ALL, andCRLF2 overexpression is a high-risk marker in T-ALL. However,CRLF2 alterations in pediatric hematologic malignancies other than B-ALL have not been reported. In this study, we analyzed theCRLF2 overexpression, rearrangements (P2RY8::CRLF2 andIGH::CRLF2 ), activation (pSTAT5 and pERK), and the expression of dominant-negativeIKZF1 isoforms (Ik6 and Ik8), implied inCRLF2 dysregulation, in 16 pediatric patients (AML,n = 9; T-ALL,n = 3; LBL,n = 2; HL,n = 1; cytopenia,n = 1). A high frequency ofCRLF2 rearrangements and overexpression was found in the 16 patients: 28.6% (4/14) showedCRLF2 overexpression, 93.8% (15/16) were positive for CRLF2 total protein (cell-surface and/or cytoplasmic), while 62.5% (10/16) were positive forP2RY8::CRLF2 and 12.6% (2/16) forIGH::CRLF2 . In addition, 43.8% (7/16) expressed Ik6 and Ik8 isoforms. However, only a few patients were positive for the surrogate markers pSTAT5 (14.3%; 2/14) and pERK (21.4%; 3/14). [ABSTRACT FROM AUTHOR]- Published
- 2024
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