1. Electrocardiographic Evaluation in Patients With Spinal Muscular Atrophy: A Case-Control Study.
- Author
-
Falsaperla, Raffaele, Vitaliti, Giovanna, Collotta, Ausilia Desiree, Fiorillo, Chiara, Pulvirenti, Alfredo, Alaimo, Salvatore, Romano, Catia, and Ruggieri, Martino
- Subjects
- *
ELECTROCARDIOGRAPHY , *SPINAL muscular atrophy , *CHILDREN'S health , *PUBLIC health , *DIAGNOSIS , *PATIENTS - Abstract
Background: This study aimed to show the impairment of autonomic cardiac conduction causing bradycardia and/or electrocardiographic alterations in children affected by spinal muscular atrophy type 1 and 2 (SMA 1 and 2). Methods: We included 25 spinal muscular atrophy patients, admitted from November 2016 to May 2017. All patients underwent an electrocardiographic examination and we studied PR and QRS intervals, P-waves and QRS amplitudes, and heart rate in spinal muscular atrophy patients compared to a control group. Results: In all patients, we found longer PRi and QRSi (P < .05), lower P-wave and QRS complex amplitudes (P < .01), and a decreased heart rate (P < .01) with respect to controls. When we divided our patients into SMA1 and SMA2 subgroups, we found that statistical differences were maintained for P-wave and QRS complex amplitudes and heart rate, but not for PRi and QRSi with respect to controls. Conclusion: We suggest the hypothesis of SMN expression on cardiac tissue condition and/or autonomic cardiac conduction. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF