Search

Your search keyword '"Agrusti, Anna"' showing total 3 results
Start Over Author "Agrusti, Anna" Topic children
3 results on '"Agrusti, Anna"'

1. Early anakinra treatment improves cardiac outcome of multisystem inflammatory syndrome in children, regardless of disease severity.

Author

Taddio, Andrea, Paolera, Sara Della, Abbagnato, Luisa, Agrusti, Anna, Badolato, Raffaele, Biscaro, Francesca, Caorsi, Roberta, Consolaro, Alessandro, Dellepiane, Rosa Maria, Fabi, Marianna, Floretta, Ilenia, Gattorno, Marco, Giangreco, Manuela, Torre, Francesco La, Maggio, Maria Cristina, Mambelli, Lorenzo, Mauro, Angela, Mastrolia, Maria Vincenza, Meneghel, Alessandra, and Montin, Davide

Subjects
PREVENTION of heart diseases, RESEARCH, METHYLPREDNISOLONE, STATISTICS, MULTISYSTEM inflammatory syndrome, BIOLOGICAL products, CONFIDENCE intervals, HEART, INTERLEUKIN-1, ACQUISITION of data, RETROSPECTIVE studies, ANTIRHEUMATIC agents, SEVERITY of illness index, TREATMENT effectiveness, INTRAVENOUS immunoglobulins, TREATMENT failure, MEDICAL records, DESCRIPTIVE statistics, RESEARCH funding, DEATH, ODDS ratio, EARLY medical intervention, LONGITUDINAL method, PATIENT safety, CHEMICAL inhibitors, EVALUATION, CHILDREN
Abstract

Objective The main aim of this study was to define the best treatment option for multisystem inflammatory syndrome in children (MIS-C) and to analyse the role of anakinra. Methods This is a multicentre retrospective cohort study. Patients were treated according to the attending physician's decision. The patients were divided into four groups on the basis of the first treatment at time of admittance: (i) IVIG, (ii) IVIG and methylprednisolone (≤2 mg/kg/day), (iii) IVIG with high-dose methylprednisolone (>2 mg/kg/day) and (iv) anakinra with or without IVIG and/or methylprednisolone. Primary outcomes were defined as the presence of at least one of the following features: death, the failure of initial treatment, meaning the need for additional treatment for clinical worsening and cardiac involvement at the end of follow-up. Results Two hundred thirty-nine patients were recruited. At univariate analysis, persistent heart involvement at discharge was more frequent in those not receiving anakinra as initial treatment (3/21 vs 66/189; P  = 0.047). After comparisons between the four treatment regimens, adjusting for the propensity score, we observed that early treatment with anakinra was associated with a lower probability of developing persistent heart disease at the end of follow-up (odds ratio: 0.6; 95% CI: 0.4–1.0). Conclusion We report that early treatment with anakinra is safe and very effective in patients with severe MIS-C. In addition, our study suggests that early treatment with anakinra is the most favourable option for patients with a higher risk of developing a severe disease outcome. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

2. Adolescents' Utilization of a Tertiary-Level Pediatric Emergency Department in Italy

Author

Giorgio Cozzi, Lisa Passaglia, Anna Agrusti, Manuela Giangreco, Rita Giorgi, Egidio Barbi, Cozzi, Giorgio, Passaglia, Lisa, Agrusti, Anna, Giangreco, Manuela, Giorgi, Rita, and Barbi, Egidio

Subjects
adolescence, children, mental health, pediatric emergency department, utilization, Pediatrics, Perinatology and Child Health
Abstract

AimDescribe the use of the emergency department of a tertiary-level children's hospital in Italy by adolescents.MethodsThis retrospective study was based on the medical records of patients aged 13 to 17 years, who accessed the emergency department of the Institute for Maternal and Child Health of Trieste, from 1 January to 31 December 2018. The primary outcome was to describe the leading causes of access, diagnoses, rate of hospitalization, and ward of destination among adolescent patients.ResultsDuring the study period, 24,599 patients accessed the department. Among them, 3,062 were adolescents, for a total of 3,895 unscheduled visits. The principal causes of access were trauma (45.3%) and organic diseases (38.8%). Two hundred and forty nine adolescents (6.4%) had mental health problems. One hundred and forty two adolescents (3.6%) Were Admitted to the Hospital, 54 of Whom (38%) to the Neuropsychiatric Ward, for Mental Health Problems.ConclusionsAmong adolescents seen in this Italian tertiary-level children's hospital, mental health problems represented a small proportion of emergency department visits but were the leading cause of urgent hospitalization.

Published
2022

3. Phenotype and Natural History of Children With Coexistent Inflammatory Bowel Disease and Celiac Disease

Author

Maurizio Fuoti, Sabrina Cardile, Paolo Lionetti, Claudio Romano, Claudia Grieco, Fabiola Giudici, Michele Citrano, Giovanni Di Nardo, Patrizia Alvisi, Martina Bianconi, Maria Pastore, Giovanna Zuin, Marina Aloi, M.T. Illiceto, Lorenzo Norsa, Matteo Bramuzzo, Elena Pozzi, Enrico Felici, Claudia Banzato, Mauro Congia, Erasmo Miele, Serena Arrigo, Anna Agrusti, Bramuzzo, Matteo, Lionetti, Paolo, Miele, Erasmo, Romano, Claudio, Arrigo, Serena, Cardile, Sabrina, Di Nardo, Giovanni, Illiceto, Maria Teresa, Pastore, Maria, Felici, Enrico, Fuoti, Maurizio, Banzato, Claudia, Citrano, Michele, Congia, Mauro, Norsa, Lorenzo, Pozzi, Elena, Zuin, Giovanna, Agrusti, Anna, Bianconi, Martina, Grieco, Claudia, Giudici, Fabiola, Aloi, Marina, and Alvisi, Patrizia

Subjects
medicine.medical_specialty, medicine.medical_treatment, Azathioprine, Disease, Inflammatory bowel disease, Gastroenterology, Autoimmune Diseases, Crohn Disease, children, inflammatory bowel disease, Internal medicine, celiac disease, medicine, Immunology and Allergy, Humans, Child, Colectomy, Puberty, Delayed, celiac disease, children, inflammatory bowel disease, business.industry, fungi, Odds ratio, medicine.disease, Inflammatory Bowel Diseases, Ulcerative colitis, Phenotype, digestive system diseases, Natural history, Case-Control Studies, Colitis, Ulcerative, Tumor Necrosis Factor Inhibitors, business, medicine.drug
Abstract

Background Adult patients with both inflammatory bowel disease (IBD) and celiac disease (CeD) have peculiar phenotypic features. This study aimed at describing the characteristics and natural history of children with both IBD and CeD. Methods This was a case-control study based on a national registry. Cases included children diagnosed with both IBD and CeD. Two matched IBD controls without CeD, and 2 matched CeD controls were selected for each case. Inflammatory bowel disease phenotype and natural history, comprising growth and pubertal development, were compared between groups. Results Forty-nine (1.75%) patients with IBD and CeD were identified out of 2800 patients with IBD. Compared with patients with IBD alone, patients with IBD and CeD presented more frequently with autoimmune diseases (odds ratio, 2.81; 95% CI, 0.97–8.37; P = 0.04). Ileocolonic localization (46.1% vs 73.1%), treatment with azathioprine (46.2% vs 71.2%), and anti-TNF biologics (46.2% vs 69.2%) were less common in patients with Crohn’s disease and CeD than in patients with Crohn’s disease alone. Patients with ulcerative colitis and CeD had an increased risk of colectomy despite similar medical treatments compared with patients with ulcerative colitis alone (13.0% vs 0%). Pubertal delay was more common in patients with IBD and CeD compared with patients with IBD alone (14.9% vs 3.2%; odds artio, 5.24; 95% CI, 1.13–33.0; P = 0.02) and CeD alone (14.9% vs 1.1%; P = 0.002). Conclusions Children with IBD and CeD may have peculiar features with a higher risk for autoimmune diseases, colectomy, and pubertal delay compared with IBD alone.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results