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Abstract: Purpose: To evaluate the treatment results of localised aggressive gastric lymphomas with favourable prognosis using chemotherapy and radiotherapy. Patients and methods: Between February 1993 and December 2004, nine patients with primary gastric high-grade lymphoma have been treated by the Lymphoma Committee of Sfax (Tunisia). The sex ratio was 1.5. The mean age was 44.9 years. Histological type was the large cell B lymphoma in 100% of the cases. Disease was stage I in eight cases and stage II in one case (Ann Arbor Classification). The treatment consisted in primary chemotherapy followed by radiotherapy of the stomach with or without regional nodes (40Gy). Results: After treatment, all patients had complete remission. With a mean follow-up of 55.7 months, one patient was lost to follow-up; the other patients were alive with complete remission. No major acute toxicities or late effects were found. Overall survival was 100% at five years. Conclusion: Chemotherapy associated with radiotherapy can be proposed to patients having localised and aggressive primary gastric lymphoma with favourable prognosis, since this treatment is well tolerated and provides satisfactory control of the disease. [Copyright &y& Elsevier]

Résumé: Les lymphomes non-hodgkiniens extraganglionnaires des tissus mous maxillofaciaux sont très rares. Nous rapportons deux cas de lymphome non-hodgkinien des parties molles maxillofaciales en rémission complète avec un recul de six et trois mois après une chimiothérapie suivie d’une radiothérapie localisée. Nous avons étudié les caractéristiques cliniques, radiologiques et histopathologiques ainsi que le traitement et le pronostic des lymphomes non-hodgkiniens extraganglionnaire des muscles maxillofaciaux. [ABSTRACT FROM AUTHOR]

Abstract: Purpose: We retrospectively analyzed anatomoclinic, therapeutic and evolutive particularities of 74 young patients (≤20 years) with nasopharyngeal carcinoma treated between 1993 and 2005. Patients and methods: Initial work-up included a fiberoptic nasofibroscopy with biopsy, tomodensitometry and/or MRI of nasopharynx and neck, chest X-ray, abdominal ultrasonography and bone scan. Patients were treated with either primary chemotherapy (epirubicin and cisplatin) followed by radiotherapy or concomitant radiochemotherapy (five fluorouracil and cisplatin). Radiotherapy was delivered to a total dose of 70 to 75 Gy to nasopharynx and involved cervical lymph nodes and 50 Gy to the remainder cervical areas. Results: The median age was 16 years. Sixty-three percent of patients had undifferentiated tumors. Sixty-six percent had locally advanced tumor. With a median follow-up of 107 months, one patient presented a local relapse, 24 patients developed distant metastases with a median delay of 7 months. The 5 years overall survival and disease-free survival were 66 and 65 %. Late complications were dominated by dry mouth and endocrine disorders. Comments: Pediatric nasopharyngeal carcinoma is characterized by an early metastatic diffusion. Local control is excellent but with severe late toxicities. New techniques of radiotherapy and new molecules of chemotherapy could improve these results. [Copyright &y& Elsevier]