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Objective To explore the optimal scheme of Chinese medicine Wuhuang decoction for nasal lavage after operation of chronic rhino-sinusitis. Methods 45 patients with chronic rhino-sinusitis diagnosed by otorhinolaryngology Department of the Affiliated Hospital of Traditional Chinese University from April to December 2017 were selected and randomly divided into treatment group 1, treatment group 2 and treatment group 3, each group of 15 patients, who were treated with Wuhuang decoction for nasal lavage. The scores of conscious symptoms, tolerance to nasal lavage and endoscopic Lund-Kennedy were given at half month, one month and three months after operation respectively. Results At half a month of lavage, one month of lavage and three months after operation, the scores of conscious symptoms and Lund-Kennedy scores of nasal endoscopy in the treatment group 1 and the treatment group 2 were lower than those in the treatment group 3, and the differences were statistically significant (P<0.05). At 1 month of lavage and 3 months after operation, there was no significant difference in the scores of conscious symptoms between the treatment group 1 and the treatment group 2(P>0.05). At 1 month of lavage, the tolerance score of nasal lavage in the treatment group 2 was lower than that in the treatment group 1 and the treatment group 3, and the difference was statistically significant (P<0.05). Conclusion The best treatment for chronic rhino-sinusitis after operation is to lavage once a day in the first half month and once every other day. [ABSTRACT FROM AUTHOR]