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Objective We aimed to determine the minimum clinically important difference (MCID) of three different item versions of the Constitution in Chinese Medicine Questionnaire (CCMQ), to facilitate the clinical application of CCMQ. Methods In total, 537 subjects were included in the analysis. All subjects voluntarily completed a comprehensive of traditional Chinese medicine ( TCM) constitution intervention (mood, diet, daily living, exercise, and acupoints). The subjects filled out the 60-item CCMQ and the Short Form Health Questionnaire (SF-36) at baseline and 3 months after the intervention. The result of the 41-item and the 30-item CCMQ were scored according to the result of the 60-item CCMQ. An anchor-based approach and a distribution-based approach were used to estimate the MCID of the three versions of the CCMQ. The anchor of the anchor-based approach was SF-36 item 1, and the analysis method were the mean change method and multiple linear regression. The standardized response mean ( SRM) was used for the distribution-based approach. Results The mean change method and multiple linear regression estimation result were averaged and rounded to whole numbers. The MCID values of the 60-item CCMQ of balanced type, qi-deficiency type, yang-deficiency type, yin-deficiency type, phlegm-dampness type, dampness-heat type, blood-stasis type, qi-depression type, and special diathesis type were 5, -5, -3, -3, -4, -4, -4, -4, and -2, respectively. The MCID values of the 41-item CCMQ were 4, -6, -4, -2, -4, -4, -4, -4, and -2, respectively. The MCID values of the 30-item CCMQ were 5, - 5, - 4, - 3, - 4, - 5, - 4, - 5, and - 2, respectively. The MCID values estimated by the anchor-based approach were higher than those estimated when SRM was 0. 2, except for the special diathesis type. Conclusion The MCID values of three different versions of the CCMQ estimated in this study can reflect the minimum score change of the CCMQ considered important and meaningful by patients, which is helpful for doctors in explaining the effect of TCM constitution intervention or setting intervention targets. [ABSTRACT FROM AUTHOR]

Objective A holistic and comprehensive analysis of traditional Chinese medicine (TCM) constitutions health states was conducted to explore the impact of different concurrently clamped constitution histories on health-related quality of life (HRQOL). Methods　Using the convenient sampling method, the Constitution in Chinese Medicine Questionnaire-41 entry short version, the Chinese verison of SF- 36, and other tools were used to measure the unpaid blood donor population aged 18 to 60 years old, and the fuzzy set qualitative comparative analysis was used to explore configuration of the TCM constitution that affected HRQOL. Results The mean age of the 2 254 study subjects included in the analysis was (30. 72±9. 78) years. The percentage of gentleness constitution was 35. 71%, and 33. 81% had a combination of more than 3 types biased constitutions. Three categories of TCM constitution groupings negatively influenced HRQOL in the physiological domain. First, non-gentleness constitution, qi-deficiency constitution, yang-deficiency constitution, phlegm-wetness constitution, and blood-stasis constitution were the core conditions; second, non-gentleness constitution, qi-deficiency constitution, phlegm-wetness constitution, blood-stasis constitution and special diathesis constitution were the core conditions; and third, all eight biased constitutions were present as core conditions. Three categories of TCM constitution groupings negatively influenced HRQOL in the psychological domain. First, non-gentleness constitution, qideficiency constitution, phlegm-wetness constitution, blood-stasis constitution, and qi-depression constitution were the core conditions; second, non-gentleness constitution, qi-deficiency constitution, yin-deficiency constitution, wetness-heat constitution, and qi-depression constitution were the core conditions; and third, all eight biased constitutions occurred as core conditions. Conclusion　The fuzzyset qualitative comparative analysis method with a configuration perspective revealed the effect of TCM constitution on HRQOL as a multi-component combination of concurrent mechanisms. The diversity of concurrently clamped constitution and the complexity of its relationship with HRQOL were fully analyzed, and this results provide a reference direction for researchers to dig deeper into the intervention pathways of TCM constitution conditioning to enhance quality of life. [ABSTRACT FROM AUTHOR]

Abstract:Objective We aimed ( ⅰ) to explore the correlation between the public′s acute stress reaction( ASR) and the constitution of traditional Chinese medicine ( TCM) during the COVID-19 epidemic and (ⅱ) to provide a basis for adjusting the constitution bias and improving the public′s ability to cope with COVID-19 under the normalized management of the epidemic. Methods From February 3 to February 15, 2022, an electronic questionnaire survey was conducted using a combination of convenient sampling and snowball sampling. Statistics of basic information (gender, age, marital status, educational background, the likelihood of believing that they are infected, the likelihood of believing that people around them are infected, whether the location is a risk area, and whether they have been vaccinated against COVID-19 ), the scores of the Stanford Acute Stress Reaction Questionnaire (SASRQ), and TCM constitution transformation scores of each subscale of a 30-Item Short Version of Constitution in Chinese Medicine Questionnaire ( CCMQ - 30) were calculated. Those with a SASRQ score of ≥40 were included in the ASR group, and those with a SASRQ score of <40 were included in the non-ASR group. The basic information and TCM constitution of the two groups were compared. Spearman correlation analysis and multiple linear regression analysis were performed to examine the correlation between the total SASRQ score and the transformation score of each CCMQ- 30 subscale. Results A total of 1 218 questionnaires were collected, of which 116 invalid questionnaires were excluded, so 1 102 samples were included in the final analysis. The effective rate of the questionnaire was 90. 48%. (ⅰ) There were 892 people in the non-ASR group and 210 people in the ASR group. There were no significant differences in gender, age, marital status, educational background, whether the location was a risk area, the possibility of infection, and vaccination between the two groups (P>0. 05), while there were significant differences in the possibility of believing that people around them are infected (P<0. 05); the proportion of people who perceived the possibility of infection was higher in the ASR group than in the non-ASR group. (ⅱ) There were significant differences in the scores of nine TCM constitutions between the ASR group and the non-ASR group (P< 0. 05). Correlation analysis showed that the total SASRQ score was negatively correlated with balanced constitution (r = -0. 353, P<0. 01), while it was positively correlated with eight biased constitutions; ordered based on the correlation from strong to weak, these constitutions were the following: qi-stagnation, qi-deficiency, blood-stasis, phlegm-dampness, inherited special, yin-deficiency, dampness-heat, and yang-deficiency (r = 0. 235 to 0. 367, P < 0. 01). ( ⅲ) Multiple linear regression analysis controlling for the interaction of biased constitutions showed that qi-stagnation( β′ = 0. 214, P<0. 01), qi-deficiency ( β′ = 0. 139, P<0. 05), and inherited special constitution ( β′ = 0. 088, P < 0. 01) were the independent influencing factors of ASR. Further control for confounding variables yielded similar result. Conclusion Qi-stagnation, qideficiency, and inherited special constitution have a great influence on public ASR. It is suggested to focus on adjusting qi-stagnation, qi-deficiency, and inherited special constitution to improve public physical and mental health under the normal management of the COVID-19 epidemic. [ABSTRACT FROM AUTHOR]