23 results on '"Hong Xu"'
Search Results
2. Effect of Danhong Injection (丹红注射液) on Improving Coronary Microcirculation Injury after Percutaneous Coronary Intervention
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Liu, Qing-rong, Liu, Hong-xu, Xing, Wen-long, Zhou, Qi, Zhang, Hong-liang, Zhang, Hai-tong, Song, Guang-yuan, and Wu, Yong-jian
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- 2021
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3. Acute Myocardial Infarction in Chinese Medicine Hospitals in China from 2006 to 2013: An Analysis of 2311 Patients from Hospital Data
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Lai, Xiao-lei, Liu, Hong-xu, Hu, Xin, Tian, Jing-feng, Shang, Ju-ju, Li, Xiang, Zhou, Qi, and Xing, Wen-long
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- 2021
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4. Huoxin Pill Reduces Myocardial Ischemia Reperfusion Injury in Rats via TLR4/NFκB/NLRP3 Signaling Pathway.
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Cao, Ce, Qi, Yu-tong, Wang, Ao-ao, Wang, Zi-yan, Liu, Zi-xin, Meng, Hong-xu, Li, Lei, and Liu, Jian-xun
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INTERLEUKINS ,BIOMARKERS ,HERBAL medicine ,ANIMAL experimentation ,WESTERN immunoblotting ,CELL receptors ,SIGNAL peptides ,NF-kappa B ,CREATINE kinase ,SUPEROXIDE dismutase ,MYOCARDIAL reperfusion complications ,CELLULAR signal transduction ,RATS ,ISOENZYMES ,MALONDIALDEHYDE ,BIOINFORMATICS ,GENE expression ,LACTATE dehydrogenase ,COMPUTER-assisted molecular modeling ,EXTRACELLULAR space ,CHINESE medicine ,TOLL-like receptors ,DRUG administration ,DRUG dosage - Abstract
Objective: To explore the protective effect of Huoxin Pill (HXP) on acute myocardial ischemia-reperfusion (MIRI) injury in rats. Methods: Seventy-five adult SD rats were divided into the sham-operated group, model group, positive drug group (diltiazem hydrochloride, DH), high dose group (24 mg/kg, HXP-H) and low dose group (12 mg/kg, HXP-L) of Huoxin Pill (n=15 for every group) according to the complete randomization method. After 1 week of intragastric administration, the left anterior descending coronary artery of the rat's heart was ligated for 45 min and reperfused for 3 h. Serum was separated and the levels of creatine kinase (CK), creatine kinase isoenzyme (CK-MB) and lactate dehydrogenase (LDH), superoxide dismutase (SOD), and malondialdehyde (MDA), hypersensitive C-reactive protein (hs-CRP) and interleukin-1β (IL-1β) were measured. Myocardial ischemia rate, myocardial infarction rate and myocardial no-reflow rate were determined by staining with Evans blue and 2,3,5-triphenyltetrazolium chloride (TTC). Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine (BATMAN) databases were used to screen for possible active compounds of HXP and their potential therapeutic targets; the results of anti-inflammatory genes associated with MIRI were obtained from GeneCards, Drugbank, Online Mendelian Inheritance in Man (OMIM), and Therapeutic Target Datebase (TTD) databases was performed; Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment were used to analyze the intersected targets; molecular docking was performed using AutoDock Tools. Western blot was used to detect the protein expression of Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NFκB)/NOD-like receptor protein 3 (NLRP3). Results: Compared with the model group, all doses of HXP significantly reduced the levels of LDH, CK and CK-MB (P<0.05, P<0.01); HXP significantly increased serum activity of SOD (P<0.05, P<0.01); all doses of HXP significantly reduced the levels of hs-CRP and IL-1β (P<0.05, P<0.01) and the myocardial infarction rate and myocardial no-reflow rate (P<0.01). GO enrichment analysis mainly involved positive regulation of gene expression, extracellular space and identical protein binding, KEGG pathway enrichment mainly involved PI3K-Akt signaling pathway and lipid and atherosclerosis. Molecular docking results showed that kaempferol and luteolin had a better affinity with TLR4, NFκB and NLRP3 molecules. The protein expressions of TLR4, NFκB and NLRP3 were reduced in the HXP group (P<0.01). Conclusions: HXP has a significant protective effect on myocardial ischemia-reperfusion injury in rats, and its effect may be related to the inhibition of redox response and reduction of the inflammatory response by inhibiting the TLR4NFκB/NLRP3 signaling pathway. [ABSTRACT FROM AUTHOR]
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- 2023
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5. Effectiveness of Integrative Medicine Therapy on Coronary Artery Disease Prognosis: A Real-World Study
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Zhao, Kang, Tian, Jin-fan, Zhao, Cong, Yuan, Fei, Gao, Zhu-ye, Li, Li-zhi, Liu, Hong-xu, Wang, Xian, Ge, Chang-jiang, and Lu, Shu-zheng
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- 2019
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6. Clinical Characteristics and Risk Factors of Periprocedural Myocardial Injury in Patients with Elective PCI in a TCM Hospital.
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Li, Xiang, Zhang, He-Yi, Shang, Ju-Ju, Liu, Hong-Xu, Zhou, Qi, and Lai, Xiao-Lei
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HYPERTENSION epidemiology ,ELECTIVE surgery ,HOSPITALS ,PERCUTANEOUS coronary intervention ,HERBAL medicine ,CONFIDENCE intervals ,CROSS-sectional method ,MULTIPLE regression analysis ,CLASSIFICATION ,ANGINA pectoris ,MYOCARDIAL injury ,RETROSPECTIVE studies ,MYOCARDIAL infarction ,PATIENTS ,SURGICAL stents ,TYPE 2 diabetes ,CORONARY artery disease ,BLOOD diseases ,MEDICAL prescriptions ,LOGISTIC regression analysis ,ODDS ratio ,CHINESE medicine ,DISEASE risk factors ,SYMPTOMS ,DISEASE complications - Abstract
Objective. To investigate the clinical characteristics of patients with unstable angina (UA) who received elective percutaneous coronary intervention (PCI) in a traditional Chinese medicine (TCM) hospital and to analyze the related risk factors of periprocedural myocardial injury (PMI). Methods. On the basis of cross-sectional investigation, the case-control method was adopted. We retrospectively collected clinical data of patients with UA who successfully received elective PCI in Beijing Hospital of TCM from February 2017 to February 2019. Based on the occurrence of PMI, the case-control was formed. The influence of related factors on PMI occurrence was analyzed using the logistic multiple regression equation based on the parameters between the comparison groups. Results. 1. Incidence of PMI and related clinical features: Of the 265 UA patients, the incidence of PMI was 26.4%, nearly one quarter (23.4%) had old myocardial infarction, nearly half (45.3%) had previously received coronary intervention. The prevalence of patients with previous hypertension (75.8%), type 2 diabetes (57%), and high-low-density lipoprotein cholesterolemia (69.3%) exceeded 50%, more than 50% of the patients have triple-vessel disease (50.2%). 2. Features of TCM syndrome elements: The main TCM syndromes of the investigated patients are blood stasis syndrome (81.1%) and Qi deficiency syndrome (77.3%), the others include Phlegm turbidity syndrome (53.2%), Yang deficiency syndrome (50.9%), Yin deficiency syndrome (50.1%), Qi stagnation syndrome (30.1%), and coagulated cold syndrome (17.1%). 3. Factors of PMI occurrence: According to the occurrence of PMI, 265 patients were divided into PMI group (n = 70) and non-PMI group (n = 195). The comparison between groups shows that the preoperative SYNTAX score, the number of stents, and the total length of stents of the patients in the PMI group were higher than those in the non-PMI group (P < 0.05); the patients in the PMI group treated by Shen-Yuan-Dan (SYD), a Chinese medicine prescription with Qi-supplementing and blood stasis-purging, were significantly lower than those in the non-PMI group (P < 0.05). Brought these four factors (preoperative SYNTAX score, number of stents implanted, total length of implanted stents, and treated by SYD) into the binary logistic regression equation, those who were only treated by SYD have statistical significance in the equation as a protective factor (OR 0.327, 95% CI 0.117–0.916, P = 0.033). Conclusion. Patients with UA who received elective PCI in TCM institutions may have clinical characteristics including multiple accompanying diseases and high stenosis coronary artery, in which the incidence of poor blood glucose control and high rate of three-vessel coronary disease are particularly significant. The TCM syndromes are mainly Qi deficiency and blood stasis syndromes. The decrease of PMI may be attributed to the application of SYD in the real world. This trial is registered at ChiCTR2100043465. [ABSTRACT FROM AUTHOR]
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- 2022
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7. Effects of Danhong Injection (丹红注射液) on Peri-Procedural Myocardial Injury and Microcirculatory Resistance in Patients with Unstable Angina Undergoing Elective Percutaneous Coronary Intervention: A Pilot Randomized Study.
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Xing, Wen-long, Wu, Yong-jian, Liu, Hong-xu, Liu, Qing-rong, Zhou, Qi, Li, Ai-yong, Zhang, Zhu-hua, and Li, Xuan
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PREVENTION of surgical complications ,ELECTIVE surgery ,DRUG efficacy ,PERIOPERATIVE care ,PILOT projects ,BIOMARKERS ,TROPONIN ,PERCUTANEOUS coronary intervention ,HERBAL medicine ,INJECTIONS ,MYOCARDIAL ischemia ,MICROCIRCULATION ,ANGINA pectoris ,SURGERY ,PATIENTS ,CREATINE kinase ,CARDIOVASCULAR agents ,RANDOMIZED controlled trials ,PLACEBOS ,COMPARATIVE studies ,BLIND experiment ,DESCRIPTIVE statistics ,STATISTICAL sampling ,MYOGLOBIN ,CHINESE medicine ,LONGITUDINAL method ,PHARMACODYNAMICS ,DRUG administration ,DRUG dosage ,EVALUATION - Abstract
Objective: To evaluate the effect of Danhong Injection (丹红注射液, DH) on the index of microcirculatory resistance (IMR) and myocardial injury in patients with unstable angina undergoing elective percutaneous coronary intervention (PCI). Methods: Seventy-eight patients with unstable angina were randomly divided into DH group (39 cases) and the control group (39 cases) during elective PCI. Randomization was performed using a random-number table. The DH group received DH at a dosage of 40 mL (mixed with 250 mL saline, covered by a light-proof bag, intravenous drip) during PCI and daily for 7 consecutive days, while the control group only received the same dosage of saline. Both groups received standardized treatment. The IMR and fractional flow reserve (FFR) were measured at maximal hyperemia before and after PCI. Myocardial markers, including myoglobin, creatine kinase (CK), creatine kinase MB (CK-MB), and coronary troponin T (cTnT) values were measured at baseline and 24 h after PCI. Results: Among the 78 patients enrolled, the baseline and procedural characteristics were similar between the two groups. There was no significant difference in pre-PCI myocardial markers and coronary physiological indexes between the two groups. However, post-PCI CK and CK-MB levels in the DH group were significantly lower than those in the control group (111.97 ± 80.97 vs. 165.47 ± 102.99, P=0.013; 13.08 ± 6.90 vs. 19.75 ± 15.49, P=0.016). Post-PCI myoglobin and cTNT-positive tend to be lower in the DH group than in the control group but did not reach statistical significance (88.07 ± 52.36 vs. 108.13 ± 90.94, P=0.52; 2.56% vs.7.69%, P=0.065). Compared with the control group, the post-IMR levels of the DH group tended to decrease, but there was no statistical difference (20.73 ± 13.15 vs. 26.37 ± 12.31, P=0.05). There were no statistical differences in post-FFR in both groups. The peri-procedural myocardial injury of the DH group was significantly lower than that of the control group (2.56% vs. 15.38%, P=0.025). During the 30-d follow-up period, no major adverse cardiovascular events occurred in either group. Conclusion: This study demonstrated benefit of DH in reducing myocardial injury and potential preserving microvascular function in patients with unstable angina undergoing elective PCI. [ABSTRACT FROM AUTHOR]
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- 2021
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8. Mechanism of 'Invigorating Qi and Promoting Blood Circulation' Drug Pair Ginseng-Danshen on Treatment of Ischemic Heart Disease Based on Network Pharmacology.
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Xin, Gao-jie, Zhao, Yu-wei, Li, Ling-mei, Jia, Fei-fan, Han, Xiao, Li, Lei, Guo, Hao, Meng, Hong-xu, Fu, Jian-hua, and Liu, Jian-xun
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INTERLEUKINS ,MEDICINAL plants ,HERBAL medicine ,CORONARY disease ,CELL receptors ,ANTIOXIDANTS ,CELLULAR signal transduction ,ADVANCED glycation end-products ,BLOOD circulation ,TUMOR necrosis factors ,GINSENG ,CHINESE medicine - Abstract
Objective: Using network pharmacology to explore the mechanism of the 'invigorating qi and promoting blood circulation' drug pair Ginseng-Danshen (Salvia miltiorrhiza) on treatment of ischemic heart disease (IHD). Methods: The chemical constituents of ginseng and Danshen drug pair were identified by searching the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and the potential targets of the pair were identified. The pharmacodynamics of the pair was analyzed using network pharmacology. The targets of IHD were identified by database screening. Using protein-protein interaction network, the interaction targets of Ginseng-Danshen on IHD were constructed. A "constituent-target-disease" interaction network was constructed using Cytoscape software, Gene Ontology (GO) term enrichment analysis and biological pathway enrichment analysis were carried out, and the mechanism of improving myocardial ischemia by the Ginseng-Danshen drug pair was investigated. Results: Seventeen active constituents and 53 targets were identified from ginseng, 53 active constituents and 61 targets were identified from Danshen, and 32 protein targets were shared by ginseng and Danshen. Twenty GO terms were analyzed, including cytokine receptor binding, cytokine activity, heme binding, and antioxidant activity. Sixty Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathways were analyzed, including phosphatidylinositol 3-kinase-serine-threonine kinase (PI3K-AKT) signaling pathway, p53 signaling pathway, interleukin 17 signaling pathway, tumor necrosis factor signaling pathway, and the advanced glycation end product (AGE)-the receptor for AGE (RAGE) signaling pathway in diabetic complications. Conclusion: The specific mechanism of Ginseng-Danshen drug pair in treating IHD may be associated with improving the changes of metabolites inbody, inhibiting the production of peroxides, removing the endogenous oxygen free radicals, regulating the expression of inflammatory factors, reducing myocardial cell apoptosis and promoting vascular regeneration. [ABSTRACT FROM AUTHOR]
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- 2021
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9. Chinese Medicine in Treatment of A Patient with Acute Extensive Anterior Myocardial Infarction Complicated by Shock after Percutaneous Coronary Intervention.
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Li, Shi-bao, Sheng, Jin, Zhou, Qi, Xing, Wen-long, Liu, Hong-xu, and Liu, Wen-xian
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ASPIRIN ,DOPAMINE ,MYOCARDIAL infarction diagnosis ,MYOCARDIAL infarction treatment ,CLOPIDOGREL ,ATORVASTATIN ,CARDIOGENIC shock ,ENOXAPARIN ,CHEST pain ,CORONARY artery stenosis ,CORONARY care units ,CORONARY disease ,HYPOTENSION ,CHINESE medicine ,SURGICAL stents ,THROMBOLYTIC therapy ,TREATMENT effectiveness ,CORONARY angiography ,PERCUTANEOUS coronary intervention ,VENTRICULAR ejection fraction ,DIAGNOSIS ,THERAPEUTICS - Published
- 2019
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10. Chinese Medicine in Australia.
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Moore, Amber, Komesaroff, Paul A., O'Brien, Kylie, Hong Xu, and Bensoussan, Alan
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DOCUMENTATION ,VOCATIONAL guidance ,EDUCATIONAL attainment ,ACUPUNCTURE ,ALTERNATIVE medicine ,BIRTHPLACES ,TEST validity ,LABOR supply ,LONGITUDINAL method ,BOTANIC medicine ,CHINESE medicine ,MULTILINGUALISM ,QUESTIONNAIRES ,RESEARCH evaluation ,SCALE analysis (Psychology) ,SURVEYS ,USER charges ,QUALITATIVE research ,PROFESSIONAL practice ,QUANTITATIVE research ,DATA analysis software ,MEDICAL coding ,WORK experience (Employment) ,DESCRIPTIVE statistics ,SOCIETIES - Abstract
Objectives: Chinese medicine is a complex domain of theoretical and practical approaches that is being increasingly put under the research spotlight. The "Chinese Medicine in Australia"research project attempted to capture the clinical features of practitioners of Chinese medicine. Participants and Interventions: The project involved a national survey of Chinese medicine professional association members and registered practitioners in the state of Victoria, Australia (n = 655; response rate, 42%-55%) completed in 2012-2013. Design: The content and face validated survey was developed using new and previous workforce survey questions. Results: This paper reports on the workforce and practice characteristics of the survey respondents. Chinese medicine practitioners are highly educated, come from diverse backgrounds, and have chosen to practice predominantly in sole or multipractitioner private practice settings. An interest in the philosophy of Chinese medicine and previous experiences contributed to practitioners' decisions to study and practice Chinese medicine. Incorporating a variety of techniques, practitioners describe themselves as practicing predominantly Chinese acupuncture and herbal medicine. Conclusions: The results from this survey contribute to the understanding of the nature and description of Chinese medicine practice in Australia. [ABSTRACT FROM AUTHOR]
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- 2016
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11. Authentication of Cordyceps sinensis by DNA Analyses: Comparison of ITS Sequence Analysis and RAPD-Derived Molecular Markers.
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Lam, Kelly Y. C., Chan, Gallant K. L., Gui-Zhong Xin, Hong Xu, Chuen-Fai Ku, Jian-Ping Chen, Ping Yao, Huang-Quan Lin, Dong, Tina T. X., and Tsim, Karl W. K.
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CORDYCEPS ,DNA analysis ,RAPD technique ,IDENTIFICATION of fungi ,CHINESE medicine - Abstract
Cordyceps sinensis is an endoparasitic fungus widely used as a tonic and medicinal food in the practice of traditional Chinese medicine (TCM). In historical usage, Cordyceps specifically is referring to the species of C. sinensis. However, a number of closely related species are named themselves as Cordyceps, and they are sold commonly as C. sinensis. The substitutes and adulterants of C. sinensis are often introduced either intentionally or accidentally in the herbal market, which seriously affects the therapeutic effects or even leads to life-threatening poisoning. Here, we aim to identify Cordyceps by DNA sequencing technology. Two different DNA-based approaches were compared. The internal transcribed spacer (ITS) sequences and the random amplified polymorphic DNA (RAPD)-sequence characterized amplified region (SCAR) were developed here to authenticate different species of Cordyceps. Both approaches generally enabled discrimination of C. sinensis from others. The application of the two methods, supporting each other, increases the security of identification. For better reproducibility and faster analysis, the SCAR markers derived from the RAPD results provide a new method for quick authentication of Cordyceps. [ABSTRACT FROM AUTHOR]
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- 2015
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12. Shen-Qi-Jie-Yu-Fang has antidepressant effects in a rodent model of postpartum depression by regulating the immune organs and subsets of T lymphocytes.
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Miao Qu, Qisheng Tang, Xiaoli Li, Ruizhen Zhao, Jingya Li, Hong Xu, Yushan Gao, and Yingqiu Mao
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ANTIDEPRESSANTS ,POSTPARTUM depression ,PSYCHIATRIC drugs ,CHINESE medicine ,T cells ,FLUOXETINE ,FLOW cytometry ,IMMUNOSUPPRESSION ,THERAPEUTICS - Abstract
Background: Shen-Qi-Jie-Yu-Fang (SJ Fang) is a herbal preparation used in traditional Chinese medicine, and is a potentially important new therapeutic agent in postpartum depression (PPD). Previously, we have elucidated the effects of SJ Fang on hormone receptors and monoamine neurotransmitters involved in the hypothalamic-pituitary-adrenal and hypothalamic-pituitarygonadal axes in PPD rats. However, the immune-modulating effects of SJ Fang in PPD are still unknown. In this study, we explored the effects of SJ Fang on the immune organs and subsets of T lymphocytes in PPD rats. Methods: PPD was created in Sprague-Dawley rats by inducing hormone-simulated pregnancy followed by hormone withdrawal. After hormone withdrawal, the PPD rats were then treated with fluoxetine at 1, 2, and 4 weeks, and the SJ Fang rats were also treated at 1, 2, and 4 weeks. Depressive behavior in the rats was evaluated by the forced swim test, sucrose consumption test, and open field test. The thymus index and spleen index were calculated. Hematoxylin-eosin staining was used to identify pathological features in the thymus and spleen. CD3, CD4, and CD8 lymphocyte subsets were analyzed by flow cytometry. Results: Both fluoxetine and SJ Fang decreased immobility time, increased sucrose consumption, an horizontal and vertical movement. After 4 weeks of treatment with fluoxetine or SJ Fang, the thymus index and spleen index were significantly higher than at baseline, and the morphology of the thymus and spleen were returning to normal. Two weeks after hormone withdrawal, subsets of T lymphocytes indicated a shift from immune activation to immune suppression, which was reversed by 4 weeks of treatment with fluoxetine or SJ Fang. Conclusion: It is suggested that T-cell mediate immune responses which may play a role in the etiopathology of postpartum depression. SJ Fang had an antidepressant effect on the immune system in rats with PPD. [ABSTRACT FROM AUTHOR]
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- 2015
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13. Specific Link between Lung and Large Intestine: A New Perspective on Neuropeptide Secretion in Lung with Herbal Laxative Stimulation.
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Xiang-Gen Zhong, Feng-Jie Zheng, Yu-Hang Li, Hong Xu, Qian Wang, Yu-Chao Liu, Miao Liu, Ruo-Han Wu, Yu-Shan Gao, Shu-Jing Zhang, Jin-Chao Zhang, Tian-Yu Zhang, and Si-Hua Gao
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CHINESE medicine ,ASTHMA diagnosis ,OBSTRUCTIVE lung disease diagnosis ,RHUBARB ,LAXATIVES ,LUNG analysis ,AIRWAY (Anatomy) ,ANIMAL experimentation ,ENZYME-linked immunosorbent assay ,EXPERIMENTAL design ,INTESTINAL mucosa ,MICE ,NEUROPEPTIDES ,RATS ,RESEARCH funding ,THERAPEUTICS - Abstract
Background. To investigate the specific link between lung and large intestine. Methods. Rat COPD-like model was prepared. Mirabilite or Chinese rhubarb was administrated intragastrically to stimulate the large intestine. Histological analysis of lung inflammation was assessed. The tissues levels of SP, VIP, NK1R, VIPR1, and VIPR2 were measured by using ELISA kits. In addition, mouse model of allergic asthma was prepared. Mirabilite was administrated intragastrically to stimulate the large intestine. Airway responsiveness and lung inflammation were assessed. The tissues levels of SP, VIP, NKA, NKB, NK1R, VIPR1, and VIPR2 were measured by using ELISA kits. Results. Stimulating the intestine with Mangxiao or Dahuang, SP, NK-1R, VIP, VIPR1, and VIPR2 were significantly increased in intestine tissues of rats with COPD and mice with asthma. Meanwhile, the SP and NK1R were significantly decreased, while VIP, VIPR1, and VIPR2 were significantly increased in lung tissues. An abnormal secretion of SP and VIP can be observed in other tissues; however, no marked changes were found in the receptors. The NKA and NKB levels were similar in lung tissues of mice with asthma among groups. Conclusions. Stimulating intestine with Mangxiao or Dahuang can specifically regulate the secretion of SP, VIP, and the receptors in lung tissues. [ABSTRACT FROM AUTHOR]
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- 2013
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14. Combination of Chinese Herbal Medicines and Conventional Treatment versus Conventional Treatment Alone in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention (5C Trial): An Open-Label Randomized Controlled, Multicenter Study.
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Shao-Li Wang, Cheng-Long Wang, Pei-Li Wang, Hao Xu, Hong-Ying Liu, Jian-Peng Du, Da-Wu Zhang, Zhu-Ye Gao, Lei Zhang, Chang-Geng Fu, Shu-Zheng Lü, Shi-Jie You, Jun-Bo Ge, Tian-Chang Li, Xian Wang, Guan-Lin Yang, Hong-Xu Liu, Jing-Yuan Mao, Rui-Jie Li, and Li-Dian Chen
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TREATMENT of acute coronary syndrome ,CHI-squared test ,COMBINED modality therapy ,CONFIDENCE intervals ,FISHER exact test ,HERBAL medicine ,MEDICINE ,CHINESE medicine ,MYOCARDIAL revascularization ,HEALTH outcome assessment ,RESEARCH funding ,STATISTICAL sampling ,STATISTICS ,T-test (Statistics) ,TRANSLUMINAL angioplasty ,DATA analysis ,RANDOMIZED controlled trials ,TREATMENT effectiveness ,PROPORTIONAL hazards models ,DATA analysis software ,ACUTE coronary syndrome ,KAPLAN-Meier estimator ,THERAPEUTICS - Abstract
Aims. To evaluate the efficacy of Chinese herbal medicines (CHMs) plus conventional treatment in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI). Methods and Results. Participants (n = 808) with ACS who underwent PCI from thirteen hospitals of mainland China were randomized into two groups: CHMs plus conventional treatment group (treatment group) or conventional treatment alone group (control group). All participants received conventional treatment, and participants in treatment group additionally received CHMs for six months. The primary end point was the composite of cardiac death, nonfatal recurrent MI, and ischemia-driven revascularization. Secondary endpoint was the composite of readmission for ACS, stroke, or congestive heart failure. The safety endpoint involved occurrence of major bleeding events. The incidence of primary endpoint was 2.7% in treatment group versus 6.2% in control group (HR, 0.43; 95% CI, 0.21 to 0.87; P = 0.015). The incidence of secondary endpoint was 3.5% in treatment group versus 8.7% in control group (HR, 0.39; 95% CI, 0.21 to 0.72; P = 0.002).No major bleeding events were observed in any participant. Conclusion. Treatment with CHMs plus conventional treatment further reduced the occurrence of cardiovascular events in patients with ACS after PCI without increasing risk of major bleeding. [ABSTRACT FROM AUTHOR]
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- 2013
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15. Metal Analysis of Si Wu Tang in Relation to its Clinical Application.
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Mary Millikan, Hong Xu, and Trevean, Hayley
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CHINESE medicine , *CHEMICAL elements , *MEDICAL prescriptions , *MEDICINAL plants , *HERBAL medicine , *PATIENT satisfaction - Abstract
Si Wu Tang, a Chinese herbal formula composed of four Chinese herbs (Danggui, Chuanxiong, Baishao and Shudi) was analysed for its magnesium, manganese, zinc, iron and calcium concentrations when made into a decoction. The commonly prescribed amount is 42 g in a specific ratio of the four herbs, and from this it was determined that all metals analysed were within safe limits and daily tolerable limits would not be able to be reached by ingesting this formula (42 g/day) alone. The highest metal in the Si Wu Tang decoction was found to be magnesium at 25 mg/L, which is under the daily intake recommendations. Varying the brewing time during the preparation of the herbs was found to have various effects on the different micronutrients when made up into separate decoctions from 1 g of each separate herb and these observations may be beneficial to Chinese medicine practitioners who wish to vary the Si Wu Tang formula to better suit a patient's needs. Samples were analysed at least in triplicate and error was found not to be over 15% at the 95% confidence level. Investigating the amount of metals present will increase the understanding of the levels of these beneficial metals and the potential curative effects they provide. [ABSTRACT FROM AUTHOR]
- Published
- 2011
16. A Preliminary Study of the Effectiveness of Chinese Therapeutic Food on Regulating Female Reproductive Hormones.
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Lulu Fu and Hong Xu
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CLINICAL trials , *ESTROGEN , *FOOD , *SEX hormones , *IMMUNOENZYME technique , *CHINESE medicine , *HEALTH outcome assessment , *PERIMENOPAUSE , *TREATMENT effectiveness , *BLIND experiment , *DESCRIPTIVE statistics - Abstract
This study investigated the effectiveness of Chinese therapeutic food on female reproductive hormones in a double-blind, placebo-controlled clinical trial. Chinese kiwi fruit extract (Hong En No. 1) was provided for Australian peri-menopausal women for one month. Chinese medical assessment and urinary 2-hydroxyestrone (2-OHE) and 16alpha-hydroxyestrone (16alpha-OHE) tests were conducted. Twenty-six urinary samples (pre and post-trial) which met the requirement of testing were analysed, the ratio 2-OHE:16alpha-OHE of pre-trial (1.18 ± 0.34) and post-trial (0.97 ± 0.29) in the control group (n = 6) decreased but showed no significant change, this ratio of pre-trial (1.44 ± 0.16) and post-trial (1.65 ± 0.21) in the treatment group (n = 7) indicated an improvement (P = 0.066), which results in beneficial hormone regulation. The Chinese medicine assessment indicated that the patterns of disharmony mainly include Liver Qi stagnation and Liver-Kidney Yin deficiency patterns. No significant change observed in the control group, significant score reduction of the patterns of disharmony was achieved at post-trial in the treatment group, which indicates an improvement of general health condition. [ABSTRACT FROM AUTHOR]
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- 2011
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17. A Study of the Comparative Effects of Hawthorn Fruit Compound and Simvastatin on Lowering Blood Lipid Levels.
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Hong Xu, Hou-En Xu, and Ryan, Damien
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ATHEROSCLEROSIS , *CARDIOVASCULAR disease treatment , *BLOOD lipids , *LABORATORY mice , *MORTALITY , *CHINESE medicine - Abstract
This project studied the lowering blood lipids effect in atherosclerotic ApoE-deficient mice. Group A mice (n = 6), fed with a normal diet, served as the negative control. The experimental groups used mice fed with a high cholesterol diet (HCD) for eight weeks, and then selected for inclusion in the study on the basis of high blood lipid levels and the formation of atherosclerotic lesion plaque, which was indicated by an ultrasound biomicroscopy test. Eighteen mice met the selection criteria (atherosclerotic mice with high blood lipid levels) and these were randomly assigned into three groups B, C and D (n = 6). Group B fed with a HCD, served as the positive control. The intervention Group C was fed with HCD and Simvastatin. The intervention Group D was fed with a HCD and Hawthorn fruit compound (HFC includes Hawthorn and Kiwi fruit extract) for eight weeks. The results showed that after feeding on a HCD, Group B had significantly higher blood lipid levels compared to Group A and this confirmed the validity of Group A and Group B controls in this study. The results also showed that compared to Group B, in both Group C and D, there was a significant reduction in triglyceride and in the ratio between low-density lipoprotein cholesterol (LDL-C) and serum cholesterol. Moreover a reduction of LDL-C was evident in Group D, whereas a similar effect did not occur in Group C. The results indicate that HFC can be considered for the treatment of hyperlipidemia and prevention of atherosclerosis. [ABSTRACT FROM AUTHOR]
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- 2009
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18. Analysis of Trace Elements in Chinese Therapeutic Foods and Herbs.
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Hong Xu and Hou-En Xu
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CHINESE cooking , *HERBAL medicine , *CHINESE medicine , *BIOACTIVE compounds , *PHARMACODYNAMICS - Abstract
The bioactive elements in Chinese therapeutic foods and herbs that are frequently consumed by people in both the East and West are analyzed. These elements in their appropriate dosage range are considered to be beneficial to health. Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and Atomic Absorption Spectrometry (AAS) were applied to determine the concentrations of various elements. Twenty-two Chinese therapeutic foods and herbs, resourced from the traditional high therapeutic quality areas or provinces were selected. Bioactive analysis focused on Lanthanum (La), Strontium (Sr), Zinc (Zn) and Selenium (Se), especially in the prevention and treatment of hyperlipidemia and its associate disorders. The higher elemental concentration herbs, La in: Rhizoma Gastrodiae Elatae, Fructus Crataegi and Herba Hedyotidis Diffusae. Sr in: Radix Puerariae and Folium Ginkgo Biloba. Zn in: Flos Carthami Tinctorii and Fructus Crataegi. Se in: Flos Lonicerae Japonicae and Portulaca Oleracea. The results mainly showed that Chinese herbs which are also therapeutic foods may be used as nutritional supplements for preventing and treating elemental deficiency, e.g., hyperlipidemia. More attention in this regard should be paid to herbs that contain La and are traditionally used for regulating cardiovascular disorders. The knowledge of the effects and concentrations of bioactive elements in foods and herbs could guide the selection of Chinese herbs in clinical practice in conjunction with traditional Chinese medicine theories. Further studies should also be considered in relation to Sr, Zn and blood regulating herbs, which could prove to be beneficial. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
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19. The Use of Preventive Strategies for Bone Loss.
- Author
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Hong Xu, Lawson, David, Kras, Annette, and Ryan, Damien
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OSTEOPOROSIS , *BONE diseases , *MENOPAUSE , *ACUPUNCTURE , *HERBAL medicine , *CHINESE medicine , *PREVENTIVE medicine - Abstract
Osteoporosis is a worldwide problem that is increasing significantly as the global population both increases and ages. While osteoporosis has been extensively studied in recent years, the utilization of traditional Chinese medicine (TCM) for the diagnosis, prevention and treatment of this condition has seldom been examined. This paper examines the theories and the literature that relate to diagnosis, prevention and treatment of bone loss at the time of menopause according to the principles of TCM. It also considers practical developments in these areas as illustrated by the authors' research findings in recent studies. TCM diagnosis attributes a number of different underlying patterns to menopausal bone loss. A very common pattern in this situation is a Kidney qi and yin deficiency pattern. TCM analysis can be used as an early determinant of those persons who are potentially at risk of bone loss. Acupuncture, herbal medicine and Tai Ji exercise can then be applied to prevent and treat osteoporosis. These treatments can be effective, if they are applied correctly. The therapies may also be used in the treatment and prevention of osteoporosis, as well as the general maintenance of women's health during menopause. [ABSTRACT FROM AUTHOR]
- Published
- 2005
- Full Text
- View/download PDF
20. Current Status and Prospect of Prevention and Treatment of Oral Diseases by Integrative Medicine.
- Author
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Zhi-Hong Xu
- Subjects
ORAL diseases ,ORAL medicine ,CHINESE medicine ,HERBAL medicine ,ORTHODONTICS - Abstract
The article presents developments and achievements in the integrative Chinese and Western medicine for the prevention and treatment of several oral diseases. Included are treatments for diseases of oral mucosa, diseases of tooth and tooth pulp, diseases of periodontal tissues, and inflammatory diseases of maxillofacial region. Also included are clinical and experimental studies on anti-tumor effect of Chinese herbs and its application on orthodontics.
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- 2006
- Full Text
- View/download PDF
21. Conference Report: AACMAC 2017 Brisbane, Australia.
- Author
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Hong Xu
- Subjects
- *
CHINESE medicine , *ACUPUNCTURE , *MEDICAL quality control , *MEDICAL care , *CONFERENCES & conventions - Published
- 2017
22. Huaier suppresses cisplatin resistance in non-small cell lung cancer by inhibiting the JNK/JUN/IL-8 signaling pathway.
- Author
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Jin, Haoyi, Liu, Changhao, Liu, Xi, Wang, Huan, Zhang, Yi, Liu, Yu, Li, Jijia, Yu, Zhanwu, and Liu, Hong-xu
- Subjects
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LUNG cancer , *INTERLEUKINS , *IN vitro studies , *IN vivo studies , *B cells , *PROTEIN kinase inhibitors , *LIQUID chromatography , *DRUG resistance , *NF-kappa B , *CELLULAR signal transduction , *CISPLATIN , *MASS spectrometry , *STEM cells , *PLANT extracts , *PHARMACEUTICAL chemistry , *TRANSCRIPTION factors , *CHINESE medicine , *PHOSPHORYLATION - Abstract
Huaier (Trametes robiniophila Murr), a traditional Chinese medicinal fungus, possesses potent anticancer efficacy and has been used as an adjuvant medication for liver, breast, gastric, intestinal, and non-small cell lung cancer (NSCLC). However, the potential regulatory functions and underlying molecular mechanisms of Huaier in cisplatin resistance of NSCLC remain unknown. To evaluate the potential regulatory functions and underlying molecular mechanisms of Huaier in cisplatin resistance of NSCLC. In vitro and in vivo experiments were employed to evaluate the regulatory functions of Huaier in cisplatin-resistant NSCLC cells. Transcriptome sequencing and validation analyses was undertaken to identify the downstream targets of Huaier. Network pharmacology, ultra-performance liquid chromatography-mass spectroscopy, and in vitro and in vivo experiments were performed to identify key small molecule drug candidates in Huaier and the regulatory mechanisms these employ to suppress cisplatin resistance in NSCLC. Huaier suppressed cisplatin resistance and cancer cell stemness in cisplatin-resistant NSCLC cells, both in vitro and in vivo. Mechanistically, Huaier could suppress expression of interleuken-8 (IL-8) through inhibition of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and activator protein-1 (AP-1), two key transcription factors responsible for the activation of IL-8 transcription. Kaempferol was identified as one of the key small molecule compounds in Huaier that could suppress cisplatin resistance by inhibiting the phosphorylation and nuclear translocation of proto-oncogene c-Jun (JUN) by binding and inhibiting the kinase activity of c-Jun N-terminal protein kinase (JNK). Huaier suppressed cisplatin resistance of NSCLC cells by inhibiting the JNK/JUN/IL-8 signaling pathway. [Display omitted] • Huaier suppresses cisplatin resistance of NSCLC cells. • AP-1/IL-8 signing pathway is main downstream targets of Huaier. • Kaempferol is one of the key small molecule compounds Huaier. • Kaempferol bind JNK to inhibit phosphorylation and nuclear translocation of c-Jun. • Supplementation of IL-8 could rescue inhibitory effect of Huaier. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
23. Danggui Buxue decoction ameliorates mitochondrial biogenesis and cognitive deficits through upregulating histone H4 lysine 12 acetylation in APP/PS1 mice.
- Author
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Chai, Gao-shang, Gong, Juan, Wu, Jia-jun, Ma, Rui-kun, Zhu, Jun, Jia, Dong-dong, Zhang, Yu-qi, Zhai, Xiao-run, Sun, Hong-xu, Nie, Yun juan, Zhao, Peng, Xu, Yi-liang, and Yu, Hai tao
- Subjects
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LYSINE metabolism , *BIOLOGICAL models , *PROTEINS , *NEURAL transmission , *ALZHEIMER'S disease , *HERBAL medicine , *STAINS & staining (Microscopy) , *ANIMAL experimentation , *WESTERN immunoblotting , *COGNITION , *PROTEOLYTIC enzymes , *PROTEIN precursors , *CELL physiology , *QUANTITATIVE research , *NEUROPLASTICITY , *MITOCHONDRIA , *AMYLOID beta-protein precursor , *QUALITATIVE research , *ELECTROPHYSIOLOGY , *HISTONES , *FLUORESCENT antibody technique , *CHINESE medicine , *NEURODEGENERATION , *MICE , *THERAPEUTICS - Abstract
Danggui Buxue decoction (DBD) is a classic herbal decoction consisting of Astragali Radix (AR) and Angelica Sinensis Radix (ASR) with a 5:1 wt ratio, which can supplement 'blood' and 'qi' (vital energy) for the treatment of clinical diseases. According to Traditional Chinese Medicine (TCM) theory, dementia is induced by Blood deficiency and Qi weakness, which causes a decline in cognition. However, the underlying mechanisms of DBD improving cognition deficits in neurodegenerative disease are no clear. This study aims at revealing the underlying mechanisms of DBD plays a protective role in the cognitive deficits and pathology process of Alzheimer's disease (AD). The APP/PS1 (Mo/HuAPP695swe/PS1-dE9) double transgenic mice were adopted as an experimental model of AD. Qualitative and quantitative analysis of 3 compounds in DBT was analyzed by HPLC. Morris water maze test, Golgi staining and electrophysiology assays were used to evaluate the effects of DBD on cognitive function and synaptic plasticity in APP/PS1 mice. Western blot, immunofluorescence and Thioflavin S staining were used for the pathological evaluation of AD. Monitoring the level of ATP, mitochondrial membrane potential, SOD and MDA to evaluate the mitochondrial function, and with the usage of qPCR and CHIP for the changes of histone post-translational modification. In the current study, we found that DBD could effectively attenuate memory impairments and enhance long-term potentiation (LTP) with concurrent increased expression of memory-associated proteins. DBD markedly decreased Aβ accumulation in APP/PS1 mice by decreasing the phosphorylation of APP at the Thr668 level but not APP, PS1 or BACE1. Further studies demonstrated that DBD restored mitochondrial biogenesis deficits and mitochondrial dysfunction. Finally, the restored mitochondrial biogenesis and cognitive deficits are under HADC2-mediated histone H4 lysine 12 (H4K12) acetylation at the peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α) and N-methyl-D-aspartate receptor type 2B (GluN2B) promoters. These findings reveal that DBD could ameliorate mitochondrial biogenesis and cognitive deficits by improving H4K12 acetylation. DBD might be a promising complementary drug candidate for AD treatment. Treated by DBD, the level of phosphorylation of APP was downregulated to cause Aβ deposition to decrease in APP/PS1 mice. Meanwhile, DBD restored mitochondrial biogenesis by the HDAC2/H4K12 acetylation/PGC-1α pathway and improved synaptic plasticity through the HDAC2/H4K12 acetylation/GluN2B pathway. In conclusion, DBD could ameliorate cognitive deficits in APP/PS1 mice. [Display omitted] • DBD ameliorated cognitive deficits in APP/PS1 mice. • DBD attenuated Aβ deposition by decreasing the phosphorylation of APP at the Thr668 level. • DBD restored mitochondrial biogenesis by the HDAC2/H4K12 acetylation/PGC-1α pathway. • DBD improved synaptic plasticity through the HDAC2/H4K12 acetylation/GluN2B pathway. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
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