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A new method to detect the vibrational circular dichroism (VCD) of a localized part of a chiral molecular system is reported. A local VCD amplifier was implemented, and the distance dependence of the amplification was investigated in a series of peptides. The results indicate a characteristic distance of 2.0±0.3 bonds, which suggests that the amplification is a localized phenomenon. The amplifier can be covalently coupled to a specific part of a molecule, and can be switched ON and OFF electrochemically. By subtracting the VCD spectra obtained when the amplifier is in the ON and OFF states, the VCD of the local environment of the amplifier can be separated from the total VCD spectrum. Switchable local VCD amplification thus makes it possible to 'zoom in' on a specific part of a chiral molecule. [ABSTRACT FROM AUTHOR]

Schwingungscirculardichroismus (VCD) wird zur Bestimmung der absoluten Konfiguration und Konformation von chiralen Molekülen in Lösung verwendet, aber niedrige Signalintensitäten und spektrale Überlappung verhindern oft die Untersuchung der lokalen Struktur. In der Zuschrift auf S. 14266 ff. beschreiben F. Hartl, W. J. Buma, S. Woutersen et al. die Anbringung eines Ferrocen ‐ basierten elektrochemisch schaltbaren Verstärkers an ein Molekül, wodurch die lokale Verstärkung des VCD ‐ Signals ermöglicht wird. [ABSTRACT FROM AUTHOR]