1. Mannose-anchored quaternized chitosan/thiolated carboxymethyl chitosan composite NPs as mucoadhesive carrier for drug delivery.
- Author
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Jin Z, Hu G, and Zhao K
- Subjects
- Acetylcysteine chemistry, Administration, Mucosal, Chemical Phenomena, Chitosan analogs & derivatives, Drug Carriers administration & dosage, Drug Liberation, HEK293 Cells, Humans, Hydrophobic and Hydrophilic Interactions, Macrophages drug effects, Mucins metabolism, Particle Size, Chitosan chemistry, Drug Carriers chemistry, Drug Delivery Systems methods, Mannose chemistry, Nanoparticles chemistry
- Abstract
There are various challenges for the mucosal delivery of drug, which is largely attributed to the absence of effective drug carriers that can make delivery to mucosal sites. In the present study, we aimed to synthesize bifunctional mucoadhesive nanoparticles (NPs) that could be used for mucosal delivery. N-2-Hydroxypropyl trimethyl ammonium chloride chitosan (M-N-2-HACC) was modified with D-mannose, and N-acetyl-L-cysteine (NAC) was immobilized on the carboxymethyl chitosan (N-CMCS). The electrostatic interaction between the two substances was used to produce mannose-modified thiolated chitosan NPs (M-N-2-HACC/N-CMCS NPs). The NPs showed a particle size of 196.72 ± 0.45 nm and zeta potential of 17.12 ± 0.50 mV. Moreover, it demonstrated high hydrophilicity, enduring drug release, stability, safety, and mucosal adhesion, which contributed to the effectiveness of mucosal administration. Additionally, the NPs could be instantly absorbed by macrophages. Collectively, these results suggested that M-N-2-HACC/N-CMCS NPs could be used as a promising candidate for mucosal delivery., (Copyright © 2022 Elsevier Ltd. All rights reserved.)
- Published
- 2022
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