1. Visible-light excitable Eu 3+ -induced hyaluronic acid-chitosan aggregates with heterocyclic ligands for sensitive and fast recognition of hazardous ions.
- Author
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Aleem AR, Ding W, Liu J, Li T, Guo Y, Wang Q, Wang Y, Wang Y, Rehman FUL, Kipper MJ, Belfiore LA, and Tang J
- Subjects
- A549 Cells, Biosensing Techniques, Chromates analysis, Humans, Iron analysis, Ligands, Light, Limit of Detection, Materials Testing, Chitosan chemistry, Europium chemistry, Hyaluronic Acid chemistry, Ions analysis
- Abstract
Water-soluble luminescent lanthanide complexes that can be excited with visible light could enable rapid detection of toxic anions and cations in biological systems. Eu
3+ -induced hyaluronic acid-chitosan aggregates (EIHCA) can improve the stability, biocompatibility, efficiency, and light absorption of luminescent Eu3+ complexes. Visible-range excitation may avoid phototoxicity associated with overexposure to UV light in biological and ecological applications. In this work, we synthesized and characterized series of EIHCA complexes having three N-donor heterocyclic ligands: 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline (Dphen), 2,2': 6',2″-terpyridine (Tpy) and 1,10-phenanthroline monohydrate (Phen). These complexes possessed bright red fluorescence with a visible range excitation maximum. The photophysical properties of one formulation (we denote as EDL6) include fast quenching response (20 s) of the fluorescence, multi-selectivity, low limit of detection, and high quenching (Ksv ) values, enabling selective, rapid and sensitive recognition of Cr2 O7 2- and Fe3+ in aqueous solution. Furthermore, EDL6 exhibits cytocompatibility with mammalian cells that make these complexes promising biocompatible candidate as a safe replacement of organic fluorophores for fluorescence sensing applications. Thus, these new EIHCA complexes were successfully employed for the selective detection of hazardous materials in biological and aqueous environment samples., (Copyright © 2021. Published by Elsevier B.V.)- Published
- 2021
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