1. Borate bonds-containing pH-responsive chitosan hydrogel for postoperative tumor recurrence and wound infection prevention.
- Author
-
Yu Y, Zhang L, Hu B, Wang Z, Gu Q, Wang W, Zhu C, and Wang S
- Subjects
- Hydrogen-Ion Concentration, Animals, Mice, Humans, Staphylococcus aureus drug effects, Boronic Acids chemistry, Escherichia coli drug effects, Cell Line, Tumor, Reactive Oxygen Species metabolism, Iron chemistry, Surgical Wound Infection prevention & control, Chitosan chemistry, Chitosan pharmacology, Hydrogels chemistry, Hydrogels pharmacology, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents chemistry, Polyvinyl Alcohol chemistry, Neoplasm Recurrence, Local prevention & control, Tannins chemistry, Tannins pharmacology
- Abstract
Chitosan has been widely used in biomedical fields due to its good antibacterial properties, excellent biocompatibility, and biodegradability. In this study, a pH-responsive and self-healing hydrogel was synthesized from 3-carboxyphenylboronic acid grafted with chitosan (CS-BA) and polyvinyl alcohol (PVA). The dynamic boronic ester bonds and intermolecular hydrogen bonds are responsible for the hydrogel formation. By changing the mass ratio of CS-BA and PVA, the tensile stress and compressive stress of hydrogel can controlled in the range of 0.61 kPa - 0.74 kPa and 295.28 kPa - 1108.1 kPa, respectively. After doping with tannic acid (TA)/iron nanocomplex (TAFe), the hydrogel successful killed tumor cells through the near infrared laser-induced photothermal conversion and the TAFe-triggered reactive oxygen species generation. Moreover, the photothermal conversion of the hydrogel and the antibacterial effect of CS and TA give the hydrogel a good antibacterial effect. The CS-BA/PVA/TAFe hydrogel exhibit good in vivo and in vitro anti-tumor recurrence and antibacterial ability, and therefore has the potential to be used as a powerful tool for the prevention of local tumor recurrence and bacterial infection after surgery., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Published
- 2024
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