1. Caveolin-3 prevents swelling-induced membrane damage via regulation of ICl,swell activity
- Author
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Daniel G.P. Turner, Leonid Tyan, Frank C. DeGuire, Roman Y. Medvedev, Sami J. Stroebel, Di Lang, and Alexey V. Glukhov
- Subjects
Mice ,HEK293 Cells ,Chlorides ,Caveolin 3 ,Chloride Channels ,Biophysics ,Animals ,Butyric Acid ,Humans ,Membrane Proteins ,Articles ,Cell Size - Abstract
Caveola membrane structures harbor mechanosensitive chloride channels (MCCs; including chloride channel 2, chloride channel 3, and SWELL1, also known as LRRC8A) that form a swelling-activated chloride current (I(Cl,swell)) and play an important role in cell volume regulation and mechanoelectrical signal transduction. However, the role of the muscle-specific caveolar scaffolding protein caveolin-3 (Cav3) in regulation of MCC expression, activity, and contribution to membrane integrity in response to mechanical stress remains unclear. Here we showed that Cav3-transfected (Cav3-positive) HEK293 cells were significantly resistant to extreme (
- Published
- 2022
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