1. An improved and scale-up synthesis of 6-hydroxybenzofuran.
- Author
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Song, Shu-Yong, Lu, He-Lin, Wang, Gui-Fei, Yang, Yi-Qiu, and Huang, Yun-Sheng
- Subjects
CHEMICAL synthesis ,HETEROCYCLIC compound derivatives ,BENZOFURAN ,ACETIC anhydride ,CHLOROACETIC acids ,DEMETHYLATION - Abstract
An optimized process for the preparation of 6-hydroxybenzofuran is described. This process consists of three steps: the reaction of 2-hydroxy-4-methoxybenzaldehyde with chloroacetic acid, the formation of the 6-methoxybenzofuran in acetic anhydride, and the demethylation with sodium 1-dodecanethiolate to afford the desired product. The entire process is safe, cost effective, environmentally benign, and scalable. A production scale of over 2.6 kg product was achieved in good overall yield. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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