1. What makes (hydroxy)chloroquine ineffective against COVID-19: insights from cell biology.
- Author
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Altulea D, Maassen S, Baranov MV, and van den Bogaart G
- Subjects
- Antiviral Agents therapeutic use, COVID-19 virology, Cell Proliferation drug effects, Chloroquine adverse effects, Drug Repositioning, Humans, Hydroxychloroquine adverse effects, SARS-CoV-2 drug effects, SARS-CoV-2 pathogenicity, Chloroquine therapeutic use, Hydroxychloroquine therapeutic use, COVID-19 Drug Treatment
- Abstract
Since chloroquine (CQ) and hydroxychloroquine (HCQ) can inhibit the invasion and proliferation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in cultured cells, the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of coronavirus disease (COVID-19). However, despite promising preliminary findings, many clinical trials showed neither significant therapeutic nor prophylactic benefits of CQ and HCQ against COVID-19. Here, we aim to answer the question of why these drugs are not effective against the disease by examining the cellular working mechanisms of CQ and HCQ in prevention of SARS-CoV-2 infections., (© The Author(s) (2021). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, CEMCS, CAS.)
- Published
- 2021
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