1. [Effects of Shengqing Capsules on cholelithiasis-related genes in guinea pigs].
- Author
-
Zhu PT, Zhang JZ, Zhang XL, Yuan ZB, Zhang HY, and Gao J
- Subjects
- Animals, Bilirubin metabolism, Capsules, Cholelithiasis genetics, Cholesterol 7-alpha-Hydroxylase genetics, Female, Glucuronosyltransferase genetics, Guinea Pigs, RNA, Messenger biosynthesis, RNA, Messenger genetics, Random Allocation, Cholelithiasis prevention & control, Cholesterol 7-alpha-Hydroxylase biosynthesis, Drugs, Chinese Herbal pharmacology, Glucuronosyltransferase biosynthesis
- Abstract
Objective: To explore the molecular mechanisms of Shengqing Capsules in treating cholelithiasis., Methods: Sixty female guinea pigs were randomized into 3 groups: group I (fed with normal diet), group II (fed with low-protein diet) and group III (fed with low-protein diet and Shengqing Capsules). After six-week feeding, the gallstone formation and the expressions of bilirubin UDP-glucuronosyltransferase (B-UGT) mRNA and cholesterol 7alpha-hydroxylase (CYP7A1) mRNA were observed., Results: The proportions of stone-formed in groups I, II and III were 2/14, 9/12 and 4/14, respectively. There were significant differences among the three groups (P<0.05). The expressions of B-UGT and CYP7A1 mRNAs were higher in both group I and group III as compared with those in the group II (P<0.05)., Conclusion: Shengqing Capsules can reduce the rate of stone-formation, which may be due to its interference of metabolism of bilirubin and cholesterol and up-regulation of the expressions of B-UGT and CYP7A1 mRNAs.
- Published
- 2005
- Full Text
- View/download PDF