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2 results on '"Xu, Shu"'

1. Puerarin prevents diabetic cardiomyopathy in vivo and in vitro by inhibition of inflammation.

Author

Yin, Mao-Shan, Zhang, Yi-Chi, Xu, Shu-Hong, Liu, Jing-Jing, Sun, Xiao-Hui, Liang, Chen, Wang, Yan, Li, Jie, Wang, Fu-Wen, Wang, Qing-Li, and Mu, Yan-Ling

Subjects
THERAPEUTIC use of isoflavones, APOPTOSIS, ASPARTATE aminotransferase, CELL culture, CHOLESTEROL, COMPARATIVE studies, CREATINE kinase, CYTOCHEMISTRY, ECHOCARDIOGRAPHY, ENZYME-linked immunosorbent assay, FLOW cytometry, HEMODYNAMICS, HISTOLOGY, IMMUNOHISTOCHEMISTRY, INFLAMMATION, ISOENZYMES, LACTATE dehydrogenase, MOLECULAR structure, POLYMERASE chain reaction, RATS, RESEARCH funding, RNA, STATISTICS, T-test (Statistics), TRIGLYCERIDES, WESTERN immunoblotting, DNA-binding proteins, ISOFLAVONES, DATA analysis, OXIDATIVE stress, PROPORTIONAL hazards models, REVERSE transcriptase polymerase chain reaction, DATA analysis software, TROPONIN, DESCRIPTIVE statistics, FLUOROIMMUNOASSAY, IN vitro studies, DIABETIC cardiomyopathy, ONE-way analysis of variance, IN vivo studies
Abstract

Diabetic cardiomyopathy (DCM) is one of the chief diabetes mellitus complications. Inflammation factors may be one reason for the damage from DM. The purpose of this research is to study the potential protective effects of puerarin on DM and the possible mechanisms of action related to NF-κB signal pathway. Following administration of puerarin to the disease model rat, several changes were observed including the changes of serum biochemical index, improved diastolic dysfunction, and enhanced endogenous antioxidant enzymes activities, further NF-κB signaling activation. Puerarin showed cardio-protective effects on DCM by inhibiting inflammation, and it might be a potential candidate for the treatment of DCM. [ABSTRACT FROM AUTHOR]

Published
2019
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2. Relationship between Angiotensin Converting Enzyme, Apelin, and New-Onset Atrial Fibrillation after Off-Pump Coronary Artery Bypass Grafting.

Author

Xu, Shu, Zhang, Jian, Xu, Yin-li, Wu, Hai-bo, Xue, Xiao-dong, and Wang, Hui-shan

Subjects
*ATRIAL fibrillation diagnosis, *CARDIOVASCULAR disease diagnosis, *HYPERTENSION, *ANGIOTENSIN converting enzyme, *ACE inhibitors, *BLOOD sugar, *C-reactive protein, *CHOLESTEROL, *CORONARY artery bypass, *CREATININE, *HEART diseases, *HIGH density lipoproteins, *INFLAMMATION, *LOW density lipoproteins, *MULTIVARIATE analysis, *PEPTIDE hormones, *POSTOPERATIVE period, *RESEARCH funding, *SURGICAL complications, *T-test (Statistics), *TRIGLYCERIDES, *LOGISTIC regression analysis, *BODY mass index, *RETROSPECTIVE studies, *DATA analysis software, *MANN Whitney U Test
Abstract

It has been shown that inflammation and oxidative stress are important factors in postoperative atrial fibrillation (POAF). Angiotensin converting enzyme (ACE) and apelin have a close relationship with inflammation and oxidative stress. The effect of ACE and apelin on POAF after off-pump coronary artery bypass grafting (OPCABG) remains a question. The concentrations of serum ACE, angiotensin II (Ang II), apelin, bradykinin (BK), malondialdehyde (MDA), and C reactive protein (CRP) were measured in the perioperative period of OPCABG. The levels of serum ACE in the POAF group were higher than in the no POAF group both preoperatively and postoperatively. Apelin in the POAF group was lower than in the no POAF group. There was a correlation between serum ACE and apelin. Postoperatively, CRP and MDA in the POAF group were higher than in the no POAF group; however, there was no difference before the operation. Preoperative ACE and apelin were both significant and independent risk factors for POAF. In conclusion, the high ACE and low apelin preoperatively led to CRP and MDA being increased postoperatively, which was probably associated with POAF after OPCABG. Apelin may be a new predictor for POAF. [ABSTRACT FROM AUTHOR]

Published
2017
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