1. Cholesterol Transport Revisited: A New Turbo Mechanism to Drive Cholesterol Excretion.
- Author
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de Boer JF, Kuipers F, and Groen AK
- Subjects
- Humans, Bile Acids and Salts metabolism, Biological Transport physiology, Cholesterol metabolism, Intestinal Mucosa metabolism, Liver metabolism
- Abstract
A fine-tuned balance between cholesterol uptake and excretion by the body is pivotal to maintain health and to remain free from the deleterious consequences of cholesterol accumulation such as cardiovascular disease. The pathways involved in intracellular and extracellular cholesterol transport are a subject of intense investigation and are being unraveled in increasing detail. In addition, insight into the complex interactions between cholesterol and bile acid metabolism has increased considerably in the last couple of years. This review provides an overview of the mechanisms involved in cholesterol uptake and excretion, with a particular emphasis on the most recent progress in this field. Special attention is given to the transintestinal cholesterol excretion (TICE) pathway, which was recently demonstrated to have a remarkably high transport capacity and to be sensitive to pharmacological modulation., (Copyright © 2017 Elsevier Ltd. All rights reserved.)
- Published
- 2018
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