1. Cholesterol-modified lignin: A new avenue for green nanoparticles, meltable materials, and drug delivery.
- Author
-
Pourmoazzen Z, Sadeghifar H, Yang G, and Lucia L
- Subjects
- Hydrophobic and Hydrophilic Interactions, Molecular Structure, Molecular Weight, Cholesterol chemistry, Drug Delivery Systems, Lignin chemistry, Nanoparticles chemistry
- Abstract
Two fractions of kraft lignin of low and high molecular weight were reacted with cholesteryl chloroformate (Chol.Cl) to produce a modified lignin that demonstrated very high hydrophobicity. Surprisingly, both fractions displayed discernible melting points as opposed to the starting lignin. The suspension in water also gave rise to nanoparticles that displayed sizes in the range of 200-500 nm that were shown to satisfactorily load and release folic acid, a representative hydrophobic molecule, within the context of drug delivery., Competing Interests: Declaration of Competing Interest The authors whose names are listed immediately below certify that they have NO affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript., (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Published
- 2020
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