1. Apparent diffusion coefficient as a prognostic factor in clival chordoma.
- Author
-
Oh HC, Hong CK, Lee KS, Cha YJ, Ahn SJ, Suh SH, and Park HH
- Subjects
- Adult, Aged, Chordoma surgery, Cranial Fossa, Posterior surgery, Female, Humans, Male, Middle Aged, Prognosis, ROC Curve, Retrospective Studies, Skull Base Neoplasms surgery, Survival Rate, Young Adult, Chordoma pathology, Cranial Fossa, Posterior pathology, Diffusion Magnetic Resonance Imaging methods, Preoperative Care, Skull Base Neoplasms pathology
- Abstract
Clival chordoma is a rare disease with high recurrence rates even after a combination of surgical resection and radiotherapy. Apparent diffusion coefficient (ADC) has been used to evaluate aggressive features of chordoma, but its utility for clival chordoma has not been explored specifically. In this study, the utility of preoperative ADC values was analyzed for predicting tumor progression and recurrence in patients with clival chordoma. Between 2012 and 2019, a total of 30 operated cases were analyzed with available preoperative ADC data. Receiver operating characteristic (ROC) analysis was used to obtain ADC cutoff values for predicting tumor aggressiveness. The mean and minimum ADC values were significantly lower in the aggressive tumor group than in the stable tumor group (both P < 0.001). ROC analysis showed that a mean cutoff ADC value of 1198 × 10
-6 mm2 /s and minimum ADC value of 895.5 × 10-6 mm2 /s could be used to predict aggressive features of clival chordoma. Subtotal resection, partial resection, and mean and minimum ADC values that were lower than cutoff values were negative predictors of overall survival and progression-free survival. In conclusion, mean and minimum ADC values could be useful in predicting aggressiveness of clival chordoma.- Published
- 2021
- Full Text
- View/download PDF