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Your search keyword '"Tolstopiatov BA"' showing total 4 results
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4 results on '"Tolstopiatov BA"'

1. [The combination treatment of malignant bone tumors using fast neutrons].

Author

Chernichenko VA, Tolstopiatov BA, Konovalenko VF, Monich AIu, and Palivets AIu

Subjects
Adult, Aged, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Bone Neoplasms mortality, Bone Neoplasms surgery, Carubicin administration & dosage, Chondrosarcoma mortality, Chondrosarcoma surgery, Chordoma mortality, Chordoma surgery, Combined Modality Therapy, Female, Humans, Male, Methotrexate administration & dosage, Middle Aged, Osteosarcoma drug therapy, Osteosarcoma mortality, Osteosarcoma surgery, Survival Rate, Bone Neoplasms radiotherapy, Chondrosarcoma radiotherapy, Chordoma radiotherapy, Fast Neutrons, Osteosarcoma radiotherapy
Abstract

The study deals with results of a clinical trial evaluating treatment efficacy of a 6 MeV neutron beam produced by Y-120 cyclotron (Kiev). Procedures of preoperative radiotherapy and radical treatment are discussed. Radiotherapy was administered to 52 patients suffering chondrosarcoma (30 cases), osteogenic sarcoma (15) or chordoma (7). Combined treatment (radiation + surgery) was given to 22 patients whereas neutron beam therapy--to 30. All patients with osteogenic sarcoma received adjuvant combination chemotherapy. Three-year survival rate was compared to that observed in controls in whom combined treatment had included gamma-therapy. A significant increase in three-year survival rate was observed for osteogenic sarcoma and chordoma whereas for chondrosarcoma the improvement in survival proved insignificant. The use of fast neutrons in combined treatment of bone tumors was considered promising.

Published
1990

2. [Treatment results in chordomas of the saccrococcygeal area].

Author

Knysh IT and Tolstopiatov BA

Subjects
Adolescent, Adult, Aged, Chordoma mortality, Female, Humans, Male, Middle Aged, Neoplasm Recurrence, Local mortality, Neoplasm Recurrence, Local therapy, Prognosis, Sacrococcygeal Region, Spinal Neoplasms mortality, Chordoma therapy, Spinal Neoplasms therapy
Abstract

The influence of various factors on the survival of 40 patients with sacral chordoma is considered. Irrespective of type of therapy, the 5-year survival after treatment of malignant chordoma was 31.5 +/- 14.6%, while in cases of benign chordoma it was 73.9 +/- 10.0%. The 10 year survival rates were 31.5 +/- 14.6 and 34.2 +/- 10.8%, respectively. The 5-year survival rates increased 3-fold after ablastic removal of tumor and by 37.9% after combination therapy (surgery + radiation). The age and sex differences had no significant prognostic value. Radical ablastic removal of sacral chordoma is of great prognostic value since it ensures favorable prognosis, irrespective of morphological type of tumor.

Published
1982

3. [The combined treatment of sacrococcygeal chordomas].

Author

Tolstopiatov BA, Palivets AIu, Konovalenko VF, Chernichenko VA, and Monich AIu

Subjects
Adolescent, Adult, Aged, Combined Modality Therapy methods, Female, Humans, Male, Middle Aged, Preoperative Care methods, Chordoma therapy, Coccyx, Sacrum, Spinal Neoplasms therapy
Published
1989

4. [Prognostic value of various factors in the treatment of patients with primary malignant tumors of the pelvic bones].

Author

Knysh IT and Tolstopiatov BA

Subjects
Adult, Bone Neoplasms mortality, Chordoma mortality, Female, Giant Cell Tumors mortality, Humans, Male, Middle Aged, Osteoma, Osteoid mortality, Plasmacytoma mortality, Prognosis, Sarcoma mortality, Time Factors, Bone Neoplasms therapy, Chordoma therapy, Giant Cell Tumors therapy, Osteoma, Osteoid therapy, Pelvic Bones, Plasmacytoma therapy, Sarcoma therapy
Abstract

The time of life of 219 patients with primary malignant tumors of bones of the pelvis were analyzed in order to study the influence of different factors on the survival rate of the patients. It was shown that a considerable improvement of some results in the treatment of chondrosarcomas and chordomas was achieved after ablative removal of tumors, in reticulosarcoma and Ewing sarcoma--after a combined chemo-radial treatment with prophylactic courses of the therapy during 2 years. The combination of operation and radiotherapy for the treatment of chordomas gave a reliably higher survival of the patients within 5 years of observation. Prognosis in osteogenic sarcoma and angiosarcoma are extremely unfavorable regardless of the method of treatment.

Published
1982

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