1. Choriocapillaris Flow Deficit in Tubercular Serpiginous-Like Choroiditis with and without Paradoxical Worsening.
- Author
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Agarwal A, Corvi F, Kumar Menia N, Aggarwal K, Erckens RJ, Berendschot TTJM, Webers CAB, Invernizzi A, Gupta V, and Sadda S
- Subjects
- Humans, Male, Female, Prospective Studies, Adult, Young Adult, Middle Aged, Regional Blood Flow physiology, Capillaries pathology, Visual Acuity physiology, Fundus Oculi, Coloring Agents administration & dosage, Blood Flow Velocity physiology, Adolescent, Choroid blood supply, Tomography, Optical Coherence methods, Fluorescein Angiography methods, Tuberculosis, Ocular diagnosis, Tuberculosis, Ocular physiopathology, Tuberculosis, Ocular complications, Tuberculosis, Ocular drug therapy, Choroiditis diagnosis, Choroiditis physiopathology, Indocyanine Green administration & dosage
- Abstract
Purpose: The aim is to analyze automated quantification of choriocapillaris flow deficit (CCFD) on swept-source (SS)-optical coherence tomography angiography (OCTA) in tubercular serpiginous-like choroiditis (TBSLC)., Methods: In this prospective study, automated CCFD calculations were performed on SS-OCTA and compared with CCFD areas on indocyanine green angiography (ICGA). Patients were divided into two groups based on the occurrence of paradoxical worsening (PW)., Results: Twenty-nine eyes (29 subjects; 18 males; mean age: 33±12 years) were included. The mean CCFD at baseline was 34.9 ± 4.3% on OCTA in eyes without PW and 35.4 ± 5.0% on SS-OCTA with PW (p = .77). At 4 and 12 weeks, CCFD on SS-OCTA improved to 30.6 ± 3.9% and 28.0 ± 4.2% (p < .001) without PW, respectively, and increased to 42.9 ± 4.4% and 48.8 ± 4.1% (p < .001) with PW, respectively. The SS-OCTA CCFD correlated well with ICGA (r = 0.48; p < .001)., Conclusions: Automated quantitative serial assessment of CCFD on SS-OCTA can serve as a useful biomarker of disease activity in eyes with TBSLC.
- Published
- 2024
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