1. Factors Associated with Success of Switching to Faricimab for Neovascular Age-Related Macular Degeneration Refractory to Intravitreal Aflibercept.
- Author
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Machida, Akira, Oishi, Akio, Ikeda, Junichiro, Kurihara, Junko, Yoneda, Ai, Tsuiki, Eiko, Hirata, Yuki, Murakami, Ryuya, and Kitaoka, Takashi
- Subjects
MACULAR degeneration ,AFLIBERCEPT ,CHOROID ,REFRACTORY materials ,ENDOTHELIAL growth factors - Abstract
We investigated the factors associated with the success of switching to faricimab for type 1 macular neovascularization (MNV) refractory to intravitreal aflibercept (IVA). This retrospective cohort study included patients with type 1 MNV who were switched to faricimab because they were refractory to IVA at two centers. The primary endpoint was a more than two-week extension of the treatment interval after 6 months. In addition, factors related to the success or failure of extension and visual and anatomical outcomes were assessed. The analysis included 43 eyes from 43 patients. Extended dosing intervals of >2 weeks were identified in 14 eyes (32.6%). A short dosing interval before switching, absence of polypoidal lesions, and thin central choroidal thickness before switching were identified as factors involved in successful extension. For patients with refractory type 1 MNV, switching to faricimab is a safe and potential option to extend existing dosing intervals. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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