1. Ocular and Periocular Metastasis in Breast Cancer: Clinical Characteristics, Prognostic Factors and Treatment Outcome.
- Author
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Yousef, Yacoub A., Mohammad, Mona, Khalil, Hanan, Khouri, Tala, Alsweiti, Rand, Khzouz, Jakub, Abu Laban, Dima, Jaradat, Imad, Ibrahimi, Ahmad Kh., Al-Ibraheem, Akram, Masri, Mahmoud Al, AlNawiaseh, Ibrahim, and Abdel-Razeq, Hikmat
- Subjects
RISK assessment ,EYE-sockets ,UVEA ,VISION disorders ,OPTIC nerve ,RESEARCH funding ,BREAST tumors ,OCULAR tumors ,TREATMENT effectiveness ,RETROSPECTIVE studies ,CANCER patients ,MAGNETIC resonance imaging ,IRIS (Eye) ,DESCRIPTIVE statistics ,METASTASIS ,LONGITUDINAL method ,DUCTAL carcinoma ,VISUAL acuity ,SURVIVAL analysis (Biometry) ,BRAIN tumors ,LOBULAR carcinoma ,DISEASE risk factors ,DISEASE complications ,SYMPTOMS - Abstract
Simple Summary: Breast cancer remains a leading cause of cancer-related mortality and morbidity worldwide. Ocular and periocular metastasis present as a rare but clinically significant manifestation. This study is crucial for understanding the rare occurrence of ocular and periocular metastasis in breast cancer. By exploring demographics and clinical aspects, we aim to improve the management of this condition. Our focus is on enhancing treatment strategies, predicting outcomes, and ultimately improving the quality of life for breast cancer patients with ocular metastasis. This study addresses the gaps in knowledge regarding the intricacies of this manifestation, driving progress toward more effective interventions and better patient outcomes. Background: Breast cancer remains a leading cause of cancer-related mortality and morbidity worldwide. Ocular and periocular metastasis present as a rare but clinically significant manifestation. This study aims to explore demographics and clinical aspects of ocular and periocular metastasis in breast cancer patients. Methods: A retrospective cohort study comprising 45 breast cancer patients with ocular or periocular metastasis treated between 2013 and 2023. Patient demographics, tumor characteristics, diagnostic methods, treatment modalities, visual outcomes, and survival data were analyzed. Results: Among 9902 breast cancer patients, 0.5% developed ocular or periocular metastasis, constituting 2.4% of metastatic cases. The median age was 50 years. Ocular metastasis timing varied: 5% before breast cancer, 24% concurrent, 22% within a year, and 49% after. The most common presentations included incidental MRI findings (42%) and vision decline (31%). Metastasis involved the orbit (47%), choroid (40%), optic nerve (11%), and iris (2%), with 44% having bilateral involvement. Predictive factors included invasive lobular carcinoma (ILC) (p < 0.0001) and brain metastasis (p < 0.0001), with ILC exhibiting a sixfold higher likelihood of ocular metastasis than invasive ductal carcinoma (IDC). Primary treatment was radiation therapy (89%), yielding a 55% maintenance of excellent vision (<0.5), with 93% developing dry eye disease. Patients with ocular metastasis faced an increased risk of disease-related mortality (p < 0.0001), with 71% succumbing within 10 months post-diagnosis. Conclusions: Ocular metastasis in breast cancer is rare (0.5%) but signifies poor outcome. It is linked to ILC and concurrent brain metastasis. Primary treatment involves radiation therapy, with a favorable visual prognosis. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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