1. [Synthesis of tumor affinity label Yb-169- and Y-90- porphyrin complexes and animal experimental investigations with various Yb-169-porphyrins]
- Author
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K, Schomäcker, M I, Gaidouk, V D, Rumyantseva, T, Fischer, H, Löhr, S, Salditt, S, Liebenhoff, and H, Schicha
- Subjects
Radioisotopes ,Mice ,Structure-Activity Relationship ,Porphyrins ,Animals ,Tissue Distribution ,Yttrium Radioisotopes ,Radiopharmaceuticals ,Ytterbium ,Radionuclide Imaging ,Bone and Bones ,Chromatography, High Pressure Liquid - Abstract
It should be shown, that it is possible to insert radioactive isotopes of Yb and Y into some selected porphyrins. Besides, first informations about the biodistribution of Yb-169-por-phyrin-complexes should be obtained.Carrier added radioactive isotopes were used for the synthesis of the metal porphyrin complexes. The animal experiments were done with mamma carcinoma bearing mice. The activity of the organs was determined 5 and 24 h after i.v. injection in a well counter.Four Yb-169-porphyrin complexes and Y-90-porphyrin complexes could be synthesized in non-carrier-free form. This was verified by absorption spectra, TLC and HPLC. Depending on the complex, the average tumour/background ratios were between 2 and 20.The synthesized radioactive metal-porphyrin complexes showed a clear tumour-affinity which could be used for tumour scintigraphy or perhaps therapy if the synthesis is improved (goal: reduction of carrier, other radionuclides).
- Published
- 1999