1. Structural MRI profiles and tau correlates of atrophy in autopsy-confirmed CTE
- Author
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Michael L. Alosco, Asim Z. Mian, Karen Buch, Chad W. Farris, Madeline Uretsky, Yorghos Tripodis, Zachary Baucom, Brett Martin, Joseph Palmisano, Christian Puzo, Ting Fang Alvin Ang, Prajakta Joshi, Lee E. Goldstein, Rhoda Au, Douglas I. Katz, Brigid Dwyer, Daniel H. Daneshvar, Christopher Nowinski, Robert C. Cantu, Neil W. Kowall, Bertrand Russell Huber, Victor E. Alvarez, Robert A. Stern, Thor D. Stein, Ronald J. Killiany, Ann C. McKee, and Jesse Mez
- Subjects
Atrophy ,Chronic traumatic encephalopathy ,Magnetic resonance imaging ,Neurodegeneration ,Tau ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background Chronic traumatic encephalopathy (CTE), a neurodegenerative tauopathy, cannot currently be diagnosed during life. Atrophy patterns on magnetic resonance imaging could be an effective in vivo biomarker of CTE, but have not been characterized. Mechanisms of neurodegeneration in CTE are unknown. Here, we characterized macrostructural magnetic resonance imaging features of brain donors with autopsy-confirmed CTE. The association between hyperphosphorylated tau (p-tau) and atrophy on magnetic resonance imaging was examined. Methods Magnetic resonance imaging scans were obtained by medical record requests for 55 deceased symptomatic men with autopsy-confirmed CTE and 31 men (n = 11 deceased) with normal cognition at the time of the scan, all >60 years Three neuroradiologists visually rated regional atrophy and microvascular disease (0 [none]–4 [severe]), microbleeds, and cavum septum pellucidum presence. Neuropathologists rated tau severity and atrophy at autopsy using semi-quantitative scales. Results Compared to unimpaired males, donors with CTE (45/55=stage III/IV) had greater atrophy of the orbital-frontal (mean diff.=1.29), dorsolateral frontal (mean diff.=1.31), superior frontal (mean diff.=1.05), anterior temporal (mean diff.=1.57), and medial temporal lobes (mean diff.=1.60), and larger lateral (mean diff.=1.72) and third (mean diff.=0.80) ventricles, controlling for age at scan (ps
- Published
- 2021
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