1. Kinase inhibition lengthens the period of the circadian pacemaker in the eye of Bulla gouldiana.
- Author
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Roberts MH, Bedian V, and Chen YL
- Subjects
- Animals, Dose-Response Relationship, Drug, Enzyme Inhibitors pharmacology, Eye drug effects, Eye metabolism, Phosphoproteins metabolism, Protein Kinases metabolism, Circadian Rhythm, Isoquinolines pharmacology, Ocular Physiological Phenomena, Opisthorchidae physiology, Protein Kinases physiology
- Abstract
The inhibition of protein kinase activity by the isoquinoline sulfonamide, H-8, lengthens the period of the Bulla ocular circadian rhythm in a dose-dependent manner. In addition, the phosphorylation of 5 proteins is markedly affected by H-8. The observed correlation between H-8's period lengthening effects, and its effects on the phosphorylation of specific proteins, suggests that: (1) these proteins are candidate components regulating the period of the circadian rhythm; and (2) the daily changes in membrane potential underlying the circadian rhythm are mediated by similar mechanisms that serve to change neural function in other systems; modulation of protein kinases.
- Published
- 1989
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