1. The Measurement of cis-Platin and trans-Platin by Graphite Atomic Absorption Spectrophotometry
- Author
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Ayumi Tanaka, Junzo Hirose, Ikuo Kushida, Tadao Sakai, Zhao Fengze, Yoshinori Kidani, and Masahide Noji
- Subjects
Trans effect ,Extraction (chemistry) ,Analytical chemistry ,General Chemistry ,General Medicine ,law.invention ,chemistry.chemical_compound ,Cis platin ,chemistry ,law ,Potassium thiocyanate ,Drug Discovery ,Nitroethane ,Graphite ,Atomic absorption spectroscopy ,Derivatization ,Nuclear chemistry - Abstract
In order to determine a micro amount of cis- and trans-platin (cis- and trans-diamminedichloroplatinum(II)) separately, we have utilized the trans effect of SCN-.cis-Platin reacted with potassium thiocyanate to give anionic [Pt(SCN)4]2- which was extracted into nitroethane as an ion pair with zephiramine. On the other hand, trans-platin gave neutral trans-[Pt(SCN)2(NH3)2] under the same conditions, which was not extracted into nitroethane. Therefore, it is possible to determine cis- and trans-platin, separately, by the solvent extraction method. In the determination of the mixture of cis- and trans-platin (4.00×10-6 and 2.67×10-6M, respectively), the recovery of each platinum complex was 94±4 and 101±10% for cis- and trans-platin, respectively.
- Published
- 1991
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