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2. The Impact of Cancer-Associated Fibroblasts on Drug Resistance, Stemness, and Epithelial-Mesenchymal Transition in Bladder Cancer: A Comparison between Recurrent and Non-Recurrent Patient-Derived CAFs.

Author

Rastegar-Pouyani, Nima, Montazeri, Vahideh, Marandi, Nikoo, Aliebrahimi, Shima, Andalib, Melika, Jafarzadeh, Emad, Montazeri, Hamed, and Ostad, Seyed Nasser

Subjects
*FIBROBLASTS, *CANCER relapse, *APOPTOSIS, *CANCER, *EPITHELIAL-mesenchymal transition, *CELL cycle, *CELL motility, *STEM cells, *CISPLATIN, *RESEARCH funding, *CELL lines, *BIOLOGICAL assay, *TRANSCRIPTION factors, *DRUG resistance in cancer cells, BLADDER tumors
Abstract

This study comparatively evaluated the possible effects of recurrent and non-recurrent patient-derived Cancer-Associated Fibroblasts (CAFs-R and -NR) on the bladder cancer cell line, EJ138. Both groups of CAFs increased cisplatin resistance and altered cell cycle distribution alongside induced resistance to apoptosis. Later, the scratch assay confirmed the cell migration-inducing effects of CAFs on cells. Nonetheless, only CAFs-R managed to increase sphere-formation and clonogenic levels in EJ138 cells, which were later validated by upregulating pluripotency transcription factors. Besides, CAFs-R also affected the expression levels of some of the EMT markers. Our study suggests that CAFs-R had stronger pro-tumorigenic effects on EJ138 cells. [ABSTRACT FROM AUTHOR]

Published
2023
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