1. Tetrahedral DNA conjugates from pentaerythritol-based polyazides.
- Author
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Ponomarenko, Anna I., Brylev, Vladimir A., Sapozhnikova, Ksenia A., Ustinov, Alexey V., Prokhorenko, Igor A., Zatsepin, Timofei S., and Korshun, Vladimir A.
- Subjects
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BIOCONJUGATES , *DNA , *NANOSTRUCTURES , *PENTAERYTHRITOL , *AZIDES , *COVALENT bonds , *RING formation (Chemistry) - Abstract
Branching points in DNA nanostructures are usually 3- or 4-way junctions maintained by Watson-Crick non-covalent interactions. However, covalently bound DNA stars could improve the diversity, strength and integrity of DNA nanoscale constructions. We report here the convenient synthesis of 3- and 4-fold pentaerythritol-based azides and their use for the assembly of branched conjugates containing the same or different oligonucleotides (ODNs) and/or fluorescent dyes by stoichiometry controlled copper (I) catalyzed azide alkyne cycloaddition (CuAAC) functionalization. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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