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The environmental management cycles for chemicals and climate change (EMC 4 ) is a suggested conceptual framework for integrating climate change aspects into chemical risk management. The interaction of climate change and chemical risk brings together complex systems that are imperfectly understood by science. Making management decisions in this context is therefore difficult and often exacerbated by a lack of data. The consequences of poor decision-making can be significant for both environmental and human health. This article reflects on the ways in which existing chemicals management systems consider climate change and proposes the EMC 4 conceptual framework, which is a tool for decision-makers operating at different spatial scales. Also presented are key questions raised by the tool to help the decision-maker identify chemical risks from climate change, management options, and, importantly, the different types of actors that are instrumental in managing that risk. Case studies showing decision-making at different spatial scales are also presented highlighting the conceptual framework's applicability to multiple scales. The United Nations Environment Programme's development of an intergovernmental Science Policy Panel on Chemicals and Waste has presented an opportunity to promote and generate research highlighting the impacts of chemicals and climate change interlinkages. Integr Environ Assess Manag 2024;20:433-453. © 2023 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC)., (© 2023 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).)

Climate change may affect stream ecosystems through flow regime alterations, which can be particularly complex in streams with a significant groundwater contribution. To quantify the impacts of climate change on hydrological regime and subsequently the stream biota, we linked SWAT-MODFLOW (A model coupling the Soil and Water Assessment Tool and the Modular Finite-difference Flow Model) with flow-biota empirical models that included indices for three key biological taxonomic identities (fish, macroinvertebrates and macrophytes) and applied the model-complex to a groundwater-dominated catchment in Denmark. Effects of predicted climate change towards the end of this century relative to the reference period (1996-2005) were tested with two contrasting climate change scenarios of different greenhouse gas emissions (Representative Concentration Pathway 2.6 (RCP 2.6) and RCP 8.5) and analysed for all subbasins grouped into streams of three size classes. The total water yield in the catchment did not change significantly (-1 ± 4 (SD) mm yr -1 ) from the baseline in the RCP2.6 scenario, while it increased by 9 ± 11 mm yr -1 in the RCP8.5 scenario. The three stream size classes underwent different alterations in flow regime and also demonstrated different biotic responses to climate change. All large and some small streams were impacted most heavily by the climate change, where fish and macrophyte indices decreased up to 14.4% and 11.2%, respectively, whereas these indices increased by up to 14.4% and 6.0%, respectively, in the medium and some small streams. The climate change effects were, as expected, larger in the RCP8.5 scenario than in the RCP2.6 scenario. Our study is the first to quantify the impacts of streamflow alterations induced by climate change on stream biota beyond specific species., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier B.V. All rights reserved.)

[Display omitted] • We translated stakeholder opinions on bioeconomy into catchment scenarios in SWAT. • Choosing the 'Sustainability first' scenario reduced total nitrogen loads below targets set for a downstream estuary. • The scenario 'Growth first' increased the total nitrogen loads by 12 % compared to baseline conditions. • Climate change on top of bioeconomy scenarios had only limited added impacts on catchment hydrology and nitrogen loads. • Investigation of seasonal changes is important to fully explore eutrophication impacts of scenarios. A societal transformation towards bio-economy will have extensive implications for land use in Nordic countries. These expected changes in land use combined with a changing climate, will have unknown consequences for water quality and quantity. To address this issue, we used the Nordic Bio-economic Pathways (NBPs), which describe five possible future scenarios (NBP1-5) for the Nordic bio-economy in 2050. The NBPs were quantified by experts using local knowledge and translated into modelling scenarios. The SWAT model was applied to simulate the effect of NBP scenarios for changes in farming intensity (varying chemical fertilizer and manure application rates), land cover change (agriculture vs forest) and nutrient loss mitigation (buffer strips and wetlands) in the River Odense catchment. Subsequently, the NBPs were combined with medium (RCP4.5) and strong (RCP8.5) climate change scenarios for the period 2041–2070 utilising the median of an ensemble of 20 and 57 climate models, respectively. Our study clearly showed that only one of the pathways, namely NBP1 (sustainability first), would enable catchment managers to fulfil the Water Framework Directive reduction target set for the total nitrogen loads in the River Odense catchment by reducing total nitrogen loads by 66%. One of the pathways (NBP5; growth first) caused an increase in the average annual total nitrogen loads by 12%, while the NBP3 scenario (self-sufficiency) reduced the total nitrogen loads with 18% compared to 2% in the case of NBP2 (business as usual) and 29 % for NBP4 (cities first). Surprisingly, climate change had only limited added impacts on the total nitrogen loads due to increased nitrogen uptake of crops. Our study provides policy makers with information on the influence of the different choices and directions taken towards transforming societies into bio-economies in the future. [ABSTRACT FROM AUTHOR]