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Your search keyword '"Aivar Lõokene"' showing total 2 results
Start Over Author "Aivar Lõokene" Topic clinical biochemistry
2 results on '"Aivar Lõokene"'

1. Enantioselective preparation of novel bicyclo[3.2.0]heptane derivatives using ester hydrolysis catalyzed by novo lipolaseTM

Author

Lilja Lahe, Ülo Lille, Välimäe Toomas, Omar Parve, Vello Kadarpik, Peeter Sikk, Aivar Lõokene, and Anne Pals

Subjects
Heptane, Bicyclic molecule, Chemistry, Organic Chemistry, Clinical Biochemistry, Enantioselective synthesis, Pharmaceutical Science, Ester hydrolysis, Biochemistry, Catalysis, Hydrolysis, chemistry.chemical_compound, Drug Discovery, Molecular Medicine, Organic chemistry, Enantiomeric excess, Molecular Biology
Abstract

Double enantioselection occurs in the case of hydrolysis of (1S,2R,5S,6R)-2-bromo-3-butanoyloxy-6-hexanoyloxybicyclo[3.2.0]heptane (13), allowing us to obtain the corresponding bromodiol (−)-(14) and epoxyalcohol (−)-(15) of high optical purity.

Published
1993

2. High-purity porcine pancreatic lipase: novel effects in catalyzing hydrolysis of esters derived from bicyclo[3.2.0]hept-2-EN-6-OLS

Author

Peeter Sikk, Anne Pals, Aivar Lõokene, Toomas Välimäe, Ülo Lille, Vello Kadarpik, and Omar Parve

Subjects
biology, Bicyclic molecule, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Catalysis, Hydrolysis, Drug Discovery, biology.protein, Molecular Medicine, Pancreatic lipase, Organic chemistry, Molecular Biology
Abstract

The responsibility of high-purity porcine pancreatic lipase (PPL), an asymmetric catalyst, has been established quantitatively in the case of hydrolysis of the title compounds. A drastic differentiation between stereoisomeric as well as homologous substrates was observed.

Published
1993

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