1. A New Method for the Assessment of Myalgia in Interstitial Lung Disease: Association with Positivity for Myositis-Specific and Myositis-Associated Antibodies
- Author
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Gianluca Sambataro, Chiara Alfia Ferrara, Carla Spadaro, Sebastiano Emanuele Torrisi, Giovanna Vignigni, Ada Vancheri, Giuseppe Muscato, Nicoletta Del Papa, Michele Colaci, Lorenzo Malatino, Stefano Palmucci, Lorenzo Cavagna, Giovanni Zanframundo, Francesco Ferro, Chiara Baldini, Domenico Sambataro, and Carlo Vancheri
- Subjects
interstitial lung disease ,myalgia ,autoantibodies ,diagnosis ,tender points ,Clinical Biochemistry ,respiratory system ,behavioral disciplines and activities ,respiratory tract diseases ,body regions ,myositis ,connective tissue disease ,fibromyalgia ,stomatognathic system - Abstract
In this study, it was found that myositis-specific and myositis-associated antibodies (MSAs and MAAs) improved the recognition of idiopathic inflammatory myopathies (IIMs) in interstitial lung disease (ILD) patients. The objective of this study is to propose a clinical method to evaluate myalgia in respiratory settings as a possible tool for the recognition of MSA/MAA positivity in ILD patients. We prospectively enrolled 167 ILD patients with suspected myositis, of which 63 had myalgia evoked at specific points (M+ILD+). We also enrolled in a 174 patients with only myalgia (M+ILD-) in a rheumatological setting. The patients were assessed jointly by rheumatologists and pulmonologists and were tested for autoantibodies. M+ILD+ patients were positive for at least one MAA/MSA in 68.3% of cases, as were M-ILD+ patients in 48.1% of cases and M+ILD- patients in 17.2% of cases (p = 0.01 and
- Published
- 2022
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