1. 2021 DORIS definition of remission in SLE:Final recommendations from an international task force
- Author
-
Yehuda Schoenfeld, Carlos Vasconcelos, Josef S Smolen, Blanca Rubio, Ricard Cervera, Nathalie Costedoat-Chalumeau, Y K Onno Teng, Søren Jacobsen, Hermine I. Brunner, Mandana Nikpour, Anne Voss, Cindy Coney, Rebecca Fischer, Sang Cheol Bae, M.W.P. Tsang-A-Sjoe, Angela Tincani, Frédéric Houssiau, Elena Zakharhova, Bernadette van Leeuw, Michelle Petri, Eric F Morand, Ian N. Bruce, Maarten Limper, Dimitrios T. Boumpas, Victoria P. Werth, Murat Inanc, Anka Askenase, Ann E. Clarke, Thomas Dörner, Cynthia Aranow, Bernardo A. Pons-Estel, Matthias Schneider, Marta Mosca, László Czirják, George Bertsias, Michael M. Ward, Hendrika Bootsma, Juanita Romero-Diaz, Marzena Olesińska, Guillermo J. Pons-Estel, Xavier Mariette, Andrea Doria, Ruth D E Fritsch-Stork, Graciela S. Alarcón, Eloisa Bonfa, David A. Isenberg, Manuel F. Ugarte-Gil, Annegret Kuhn, Martin Aringer, Laurent Arnaud, Sandra V. Navarra, David Jayne, Anisur Rahman, Raquel Faria, Caroline Gordon, Alexandre E. Voskuyl, Ronald F van Vollenhoven, van Vollenhoven, Ronald F [0000-0001-6438-8663], Doria, Andrea [0000-0003-0548-4983], Morand, Eric [0000-0002-9507-3338], Petri, Michelle A [0000-0003-1441-5373], Pons-Estel, Bernardo A [0000-0003-2518-0266], Ugarte-Gil, Manuel Francisco [0000-0003-1728-1999], Arnaud, Laurent [0000-0002-8077-8394], Bruce, Ian N [0000-0003-3047-500X], Houssiau, Frédéric A [0000-0003-1451-083X], Aringer, Martin [0000-0003-4471-8375], Bae, Sang-Cheol [0000-0003-4658-1093], Boumpas, Dimitrios T [0000-0002-9812-4671], Brunner, Hermine [0000-0001-9478-2987], Dörner, Thomas [0000-0002-6478-7725], Jacobsen, Søren [0000-0002-5654-4993], Teng, Y K Onno [0000-0001-9920-2195], Tsang-A-Sjoe, Michel [0000-0002-4982-3505], Werth, Victoria P [0000-0003-3030-5369], Aranow, Cynthia [0000-0001-9299-0053], Apollo - University of Cambridge Repository, Teng, YK Onno [0000-0001-9920-2195], Jayne, David [0000-0002-1712-0637], UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, and UCL - (SLuc) Service de rhumatologie
- Subjects
medicine.medical_specialty ,Prednisolone ,Immunology ,Therapeutics ,Disease ,Severity of Illness Index ,Health care ,medicine ,therapeutics ,Humans ,Lupus Erythematosus, Systemic ,Medical physics ,healthcare ,lupus erythematosus ,outcome assessment ,systemic ,Clinical care ,skin and connective tissue diseases ,Lupus erythematosus ,Epidemiology and outcomes ,Task force ,business.industry ,Healthcare ,Systemic ,Remission Induction ,General Medicine ,RC581-607 ,medicine.disease ,Clinical trial ,Outcome assessment ,Research questions ,Observational study ,Immunologic diseases. Allergy ,business ,Immunosuppressive Agents - Abstract
ObjectiveTo achieve consensus on a definition of remission in SLE (DORIS).BackgroundRemission is the stated goal for both patient and caregiver, but consensus on a definition of remission has been lacking. Previously, an international task force consisting of patient representatives and medical specialists published a framework for such a definition, without reaching a final recommendation.MethodsSeveral systematic literature reviews were performed and specific research questions examined in suitably chosen data sets. The findings were discussed, reformulated as recommendations and voted on.ResultsBased on data from the literature and several SLE-specific data sets, a set of recommendations was endorsed. Ultimately, the DORIS Task Force recommended a single definition of remission in SLE, based on clinical systemic lupus erythematosus disease activitiy index (SLEDAI)=0, Evaluator’s Global Assessment ConclusionThe 2021 DORIS definition of remission in SLE is recommended for use in clinical care, education, and research including clinical trials and observational studies.
- Published
- 2021