1. Primary Cerebral ALK-1-Positive Anaplastic Large Cell Lymphoma in a Child
- Author
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Timothy M. George, Anand S. Lagoo, Thomas J. Cummings, Keyne K. Thomas, and Isaac O. Karikari
- Subjects
Pathology ,medicine.medical_specialty ,medicine.diagnostic_test ,Pineal region ,business.industry ,Large cell ,New onset seizures ,Central nervous system ,Clinical course ,General Medicine ,medicine.disease ,Lymphoma ,medicine.anatomical_structure ,hemic and lymphatic diseases ,Pediatrics, Perinatology and Child Health ,Biopsy ,medicine ,Surgery ,Neurology (clinical) ,business ,Anaplastic large-cell lymphoma - Abstract
A 4-year-old African American male was referred to the Pediatric Neurosurgery Service for evaluation of new onset seizures and worsening mental status. An MRI of the brain revealed a pineal region mass with diffuse leptomeningeal enhancement and compression of the basilar cisterns. A biopsy of the brain revealed histologic and immunophenotypic findings characteristic of ALK-1+ anaplastic large cell lymphoma (ALCL). ALCL rarely occurs in the central nervous system and poses a significant diagnostic challenge often leading to a delay in the initiation of appropriate treatment. We describe a case of a rapidly deteriorating clinical course in a child with central nervous system ALCL and review the current literature on ALCL occurring in the central nervous system.
- Published
- 2007
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